Mesoangioblasts at 20: From the embryonic aorta to the patient bed.

In 2002 we published an article describing a population of vessel-associated progenitors that we termed mesoangioblasts (MABs). During the past decade evidence had accumulated that during muscle development and regeneration things may be more complex than a simple sequence of binary choices (e.g., dorsal vs. ventral somite). LacZ expressing fibroblasts could fuse with unlabelled myoblasts but not among themselves or with other cell types. Bone marrow derived, circulating progenitors were able to participate in muscle regeneration, though in very small percentage. Searching for the embryonic origin of these progenitors, we identified them as originating at least in part from the embryonic aorta and, at later stages, from the microvasculature of skeletal muscle. While continuing to investigate origin and fate of MABs, the fact that they could be expanded

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Copyright © 2023 Cossu, Tonlorenzi, Brunelli, Sampaolesi, Messina, Azzoni, Benedetti, Biressi, Bonfanti, Bragg, Camps, Cappellari, Cassano, Ciceri, Coletta, Covarello, Crippa, Cusella-De Angelis, De Angelis, Dellavalle, Diaz-Manera, Galli, Galli, Gargioli, Gerli, Giacomazzi, Galvez, Hoshiya, Guttinger, Innocenzi, Minasi, Perani, Previtali, Quattrocelli, Ragazzi, Roostalu, Rossi, Scardigli, Sirabella, Tedesco, Torrente and Ugarte.

Déclaration de conflit d'intérêts

MC is employed by Lunapore. GG and HH by Cell Fiber.Co. GR by Roche and UR by Gupra. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer (KV) declared a shared parent affiliation with the author(s) (MQ) to the handling editor at the time of review.