Chronic Myeloid Leukemia: Chronic Phase Presenting as Extramedullary Presentation.
chronic myeloid leukemia
chronic phase
myeloid sarcoma
parotid gland
tyrosine kinase inhibitors (tkis) therapy
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
13
10
2022
accepted:
19
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by immature granulocytes in the peripheral blood and bone marrow. In 95% of cases, it is always associated with the presence of the Philadelphia chromosome, which is characterized by the presence of reciprocal translocation between chromosomes 9 and 22. However, 3.1-9.1% of patients also have an extramedullary proliferation of skin, lymph nodes, bone, or central nervous system (CNS), which could be either myeloid, lymphocytic, or mixed lineage in origin. An extramedullary myelogenous neoplasm termed myeloid sarcoma (MS) can originate from myeloblasts or immature myeloid cells. Due to the green, gross appearance caused by the myeloperoxidase enzyme in immature myeloid cells, it is also known as chloroma. According to WHO guidelines, it is a tumor composed of myeloid blasts, mature or immature. Here we report an old female patient with CML - chronic phase who came for imatinib therapy and presented as MS in the right parotid gland.
Identifiants
pubmed: 36686093
doi: 10.7759/cureus.32691
pmc: PMC9848683
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e32691Informations de copyright
Copyright © 2022, Nanote et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Cytol. 2009 Apr;26(2):88-90
pubmed: 21938162
Mayo Clin Proc. 2015 Oct;90(10):1440-54
pubmed: 26434969
Blood. 2016 Jan 7;127(1):53-61
pubmed: 26660429
Blood Res. 2020 Jun 30;55(2):112-115
pubmed: 32375463
Am J Surg Pathol. 2016 Nov;40(11):1473-1483
pubmed: 27631510
Blood Rev. 2006 Jan;20(1):29-41
pubmed: 16426942