Biological Functions of Selenoprotein Glutathione Peroxidases (GPXs) and their Expression in Osteoarthritis.
biological functions
glutathione peroxidase
osteoarthritis
Journal
Journal of inflammation research
ISSN: 1178-7031
Titre abrégé: J Inflamm Res
Pays: New Zealand
ID NLM: 101512684
Informations de publication
Date de publication:
2023
2023
Historique:
received:
19
09
2022
accepted:
24
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
In order to further study the biological functions of glutathione peroxidases (GPXs) and their expression level in patients with osteoarthritis (OA), we fully explored the potential relationship between GPXs and OA. This will provide new ideas for basic biological studies and therapeutic strategies for OA patients. In this study, bioinformatics techniques were used to explore the biological functions of five GPXs. The core genes related to the biological functions of GPXs were identified by constructing a protein-protein interaction network (PPI). In addition, we utilized microarray data in public databases to analyze the expression levels of GPXs in OA patients and healthy controls. Finally, we used quantitative real-time polymerase chain reaction (qRT-PCR) to detect the expression of GPXs in OA patients and controls to validate our bioinformatic analysis results. Enrichment analysis showed GPXs were mainly enriched in the glutathione metabolic pathway and participate in the biological process of oxidative stress response, and further play an antioxidant role. The PPI network indicated that superoxide dismutase 1 (SOD1), superoxide dismutase 2(SOD2) and catalase (CAT) were the core proteins of this network. GPXs play an important antioxidant role in oxidative stress response. The expression of
Identifiants
pubmed: 36686275
doi: 10.2147/JIR.S388934
pii: 388934
pmc: PMC9848624
doi:
Types de publication
Journal Article
Langues
eng
Pagination
183-196Informations de copyright
© 2023 Zhao et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Osteoarthritis Cartilage. 2015 Jan;23(1):22-30
pubmed: 25452156
Free Radic Biol Med. 2019 Feb 20;132:73-82
pubmed: 30176344
Br J Biomed Sci. 1996 Dec;53(4):317-24
pubmed: 9069110
Breast Cancer Res. 2001;3(5):323-7
pubmed: 11597322
Antioxid Redox Signal. 2008 Sep;10(9):1501-14
pubmed: 18498225
Free Radic Biol Med. 2018 Sep;125:15-24
pubmed: 29601945
Arthritis Rheum. 1986 Aug;29(8):1039-49
pubmed: 3741515
Lancet. 2018 Nov 10;392(10159):1789-1858
pubmed: 30496104
Ann Rheum Dis. 2014 Oct;73(10):1844-53
pubmed: 23864235
Science. 2003 May 30;300(5624):1439-43
pubmed: 12775843
Semin Arthritis Rheum. 2015 Apr;44(5):531-541
pubmed: 25511476
Carcinogenesis. 2000 May;21(5):909-14
pubmed: 10783311
PLoS One. 2017 Sep 5;12(9):e0184129
pubmed: 28873455
Nucleic Acids Res. 2019 Jul 2;47(W1):W234-W241
pubmed: 30931480
Nat Rev Rheumatol. 2019 Jan;15(1):9-17
pubmed: 30341437
Exp Ther Med. 2021 Jan;21(1):72
pubmed: 33365072
J Biomed Mater Res B Appl Biomater. 2016 Jul;104(5):993-1003
pubmed: 25994972
Lancet. 2019 Apr 27;393(10182):1745-1759
pubmed: 31034380
Nat Med. 2011 Nov 06;17(12):1674-9
pubmed: 22057346
Osteoarthritis Cartilage. 2006 Jan;14(1):13-29
pubmed: 16242352
Br Med Bull. 2013;105:185-99
pubmed: 23337796
Adv Clin Chem. 2021;100:37-90
pubmed: 33453867
Curr Protoc Bioinformatics. 2020 Dec;72(1):e106
pubmed: 32986267
Inflammopharmacology. 2020 Jun;28(3):667-695
pubmed: 32144521
Biochim Biophys Acta. 2013 May;1830(5):3289-303
pubmed: 23201771
Bone Res. 2021 Mar 17;9(1):20
pubmed: 33731688
Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361
pubmed: 27899662
Antioxid Redox Signal. 2007 Oct;9(10):1541-67
pubmed: 17678439
Osteoarthritis Cartilage. 2002 Feb;10(2):119-26
pubmed: 11869071
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
J Clin Med. 2021 Sep 21;10(18):
pubmed: 34575394
Adv Mater. 2021 Jan;33(2):e2005215
pubmed: 33251635
Medicina (Kaunas). 2019 May 16;55(5):
pubmed: 31100974
Arthritis Res Ther. 2017 Feb 2;19(1):18
pubmed: 28148295
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W167-74
pubmed: 24861621
Arthritis Rheumatol. 2014 Apr;66(4):960-8
pubmed: 24757147
Curr Pharm Des. 2004;10(14):1647-52
pubmed: 15134562
Profiles Drug Subst Excip Relat Methodol. 2015;40:43-158
pubmed: 26051685
Osteoarthritis Cartilage. 2006 Feb;14(2):139-45
pubmed: 16289733
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
Lancet. 2000 Jul 15;356(9225):233-41
pubmed: 10963212
J Orthop Translat. 2021 Sep 10;32:21-27
pubmed: 35591935
Biochim Biophys Acta. 2016 Apr;1862(4):576-591
pubmed: 26769361
J Biol Chem. 2014 Mar 28;289(13):8735-41
pubmed: 24515117
Ann N Y Acad Sci. 2017 Aug;1401(1):114-135
pubmed: 28662306
Free Radic Biol Med. 1994 Sep;17(3):235-48
pubmed: 7982629
Antioxid Redox Signal. 2013 Apr 20;18(12):1497-534
pubmed: 22938635
Metabolism. 2016 Feb;65(2):12-9
pubmed: 26773925
J Orthop Translat. 2021 Jun 12;32:12-20
pubmed: 35591938
Front Mol Biosci. 2022 Sep 20;9:1001212
pubmed: 36203877
Bioengineered. 2022 Jan;13(1):1746-1757
pubmed: 35001833
BMC Musculoskelet Disord. 2013 Dec 15;14:354
pubmed: 24330574
J Bone Joint Surg Am. 2021 Aug 4;103(15):1451-1461
pubmed: 34014853
Bioact Mater. 2021 Oct 26;12:327-339
pubmed: 35128180