Case report: Motor neuron disease phenotype associated with symptomatic copper deficiency: Challenging diagnosis and treatment.
amyotrophic lateral sclerosis (ALS)
cerulopasmin
copper deficiency
motoneuron
myelopathy
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
10
2022
accepted:
18
11
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
Copper deficiency is an acquired condition that can lead to neurologic dysfunctions, such as myelopathy, motor neuron impairment, polyneuropathy, cognitive impairment, and optic nerve neuropathy. Associated biological findings are low serum copper and ceruloplasmin levels with low copper urinary excretion. We report the case of a previously healthy 59-year-old man who presented a complex neurological picture starting with symptoms and radiological signs consistent with degenerative myelopathy in the presence of persisting low serum copper and ceruloplasmin despite oral and intravenous copper supplementation. Over time, his symptoms evolved into a motor neuron disease evocating an amyotrophic lateral sclerosis (ALS) phenotype. The potential role of copper deficiency is discussed, together with the difficulties in biomonitoring copper supplementation.
Identifiants
pubmed: 36686537
doi: 10.3389/fneur.2022.1063803
pmc: PMC9845570
doi:
Types de publication
Case Reports
Langues
eng
Pagination
1063803Informations de copyright
Copyright © 2023 Benkirane, Warlop, Ivanoiu, Baret, Wiame, Haufroid, Duprez and Hantson.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Biol Trace Elem Res. 1997 Feb;56(2):187-201
pubmed: 9164664
J Nutr. 1979 Nov;109(11):1979-2066
pubmed: 387922
Biochemistry. 2010 Jul 13;49(27):5714-25
pubmed: 20515040
Nutr Clin Pract. 2021 Oct;36(5):1080-1085
pubmed: 33037701
Nutr Clin Pract. 2019 Aug;34(4):504-513
pubmed: 31209935
Pharmacol Toxicol. 2000 Sep;87(3):126-30
pubmed: 11068853
Neurology. 2004 Jul 13;63(1):33-9
pubmed: 15249607
J Nutr Metab. 2018 Jul 19;2018:5678698
pubmed: 30116640
Eur J Neurol. 2022 Aug;29(8):2173-2180
pubmed: 35460312
Clin Neurophysiol. 2019 Feb;130(2):307-314
pubmed: 30573424
Muscle Nerve. 2006 Dec;34(6):789-93
pubmed: 16929546
Neurol Sci. 2017 Sep;38(9):1609-1615
pubmed: 28601974
Gastroenterology. 1988 Feb;94(2):508-12
pubmed: 3335323
Neurologist. 2009 Nov;15(6):355-6
pubmed: 19901719
Biol Signals. 1994 Jul-Aug;3(4):193-7
pubmed: 7834014
Obesity (Silver Spring). 2009 Apr;17(4):827-31
pubmed: 19148115
Eur J Haematol. 2008 Jun;80(6):523-31
pubmed: 18284630
J Neurol Sci. 1997 Apr 15;147(2):171-5
pubmed: 9106124
Int J Mol Sci. 2020 Dec 04;21(23):
pubmed: 33291628
Arch Neurol. 2004 May;61(5):762-6
pubmed: 15148156
Neurotoxicology. 2009 Nov;30(6):996-9
pubmed: 19732792
Expert Rev Mol Med. 2017 Jun 9;19:e7
pubmed: 28597807
J Neurol. 2006 Nov;253(11):1507-9
pubmed: 16972121
Neuroradiology. 2006 Feb;48(2):78-83
pubmed: 16261334