A new chiral phenomenon of orientational chirality, its synthetic control and computational study.
and sonogashira coupling
atropisomerism
orientational chirality
rotamer
suzuki-miyaura coupling
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
11
2022
accepted:
19
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
A new type of chirality, orientational chirality, consisting of a tetrahedron center and a remotely anchored blocker, has been discovered. The key structural element of this chirality is characterized by multiple orientations directed by a through-space functional group. The multi-step synthesis of orientational chiral targets was conducted by taking advantage of asymmetric nucleophilic addition, Suzuki-Miyaura cross-coupling and Sonogashira coupling. An unprecedented catalytic species showing a five-membered ring consisting of C (sp
Identifiants
pubmed: 36688043
doi: 10.3389/fchem.2022.1110240
pii: 1110240
pmc: PMC9850238
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1110240Informations de copyright
Copyright © 2023 Jin, Xu, Tang, Wang, Wang, Pan, Zhang, Yuan, Rahman, Aquino, Lischka and Li.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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