Analysis of
AVPR1A
genotype
pain
quantitative sensory testing (QST)
sickle cell disease
stress
Journal
Frontiers in pain research (Lausanne, Switzerland)
ISSN: 2673-561X
Titre abrégé: Front Pain Res (Lausanne)
Pays: Switzerland
ID NLM: 9918227269806676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
03
10
2022
accepted:
06
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
In patients with sickle cell disease (SCD), negative physical and emotional experiences result from intense chronic and acute pain episodes, but factors underlying these, and their interactions, are not well understood. The arginine vasopressin receptor 1a gene ( 150 adults enrolled with SCD completed pain intensity measures (Average Pain Intensity, API) and the Perceived Stress Questionnaire (PSQ). Thermal and pressure pain threshold data were available from quantitative sensory testing (QST), and rs10877969 genotypes were obtained. In models adjusted for age and gender, between rs10877969 genotypes, we observed no significant differences in thermal (cold, Clinical and experimental pain were not significantly associated with the rs10877969 genotype. The rs10877969 genotype did not moderate the correlation between environmental stress and clinical pain in this population. However, a trend toward a protective T allele effect on average pain rating in SCD warrants future exploration of this SNP/gene in SCD.
Identifiants
pubmed: 36688082
doi: 10.3389/fpain.2022.1060245
pmc: PMC9845903
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1060245Subventions
Organisme : NHLBI NIH HHS
ID : K01 HL153210
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL140031
Pays : United States
Informations de copyright
© 2023 Powell-Roach, Yao, Cao, Chamala, Wallace, Cruz-Almeida, Molokie, Wang and Wilkie.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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