Neurofilament light level correlates with brain atrophy, and cognitive and motor performance.
brain atrophy
cognitive performance
motor performance
neurofilament light
small vessel disease
white matter hyperintensities
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
05
2022
accepted:
09
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
24
1
2023
Statut:
epublish
Résumé
The usefulness of neurofilament light (NfL) as a biomarker for small vessel disease has not been established. We examined the relationship between NfL, neuroimaging changes, and clinical findings in subjects with varying degrees of white matter hyperintensity (WMH). A subgroup of participants (n = 35) in the Helsinki Small Vessel Disease Study underwent an analysis of NfL in cerebrospinal fluid (CSF) as well as brain magnetic resonance imaging (MRI) and neuropsychological and motor performance assessments. WMH and structural brain volumes were obtained with automatic segmentation. CSF NfL did not correlate significantly with total WMH volume (r = 0.278, NfL was strongly related to global gray matter and hippocampal atrophy, but not to WMH severity. NfL was also associated with motor performance. Our results suggest that NfL is independently associated with brain atrophy and functional mobility, but is not a reliable marker for cerebral small vessel disease.
Sections du résumé
Background
UNASSIGNED
The usefulness of neurofilament light (NfL) as a biomarker for small vessel disease has not been established. We examined the relationship between NfL, neuroimaging changes, and clinical findings in subjects with varying degrees of white matter hyperintensity (WMH).
Methods
UNASSIGNED
A subgroup of participants (n = 35) in the Helsinki Small Vessel Disease Study underwent an analysis of NfL in cerebrospinal fluid (CSF) as well as brain magnetic resonance imaging (MRI) and neuropsychological and motor performance assessments. WMH and structural brain volumes were obtained with automatic segmentation.
Results
UNASSIGNED
CSF NfL did not correlate significantly with total WMH volume (r = 0.278,
Conclusion
UNASSIGNED
NfL was strongly related to global gray matter and hippocampal atrophy, but not to WMH severity. NfL was also associated with motor performance. Our results suggest that NfL is independently associated with brain atrophy and functional mobility, but is not a reliable marker for cerebral small vessel disease.
Identifiants
pubmed: 36688160
doi: 10.3389/fnagi.2022.939155
pmc: PMC9849573
doi:
Types de publication
Journal Article
Langues
eng
Pagination
939155Informations de copyright
Copyright © 2023 Kartau, Melkas, Kartau, Arola, Laakso, Pitkänen, Lempiäinen, Koikkalainen, Lötjönen, Korvenoja, Ahlström, Herukka, Erkinjuntti and Jokinen.
Déclaration de conflit d'intérêts
JKo and JLö are employed by Combinostics Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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