Single-cell profiling reveals differences between human classical adenocarcinoma and mucinous adenocarcinoma.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
23 01 2023
23 01 2023
Historique:
received:
02
12
2021
accepted:
09
01
2023
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
26
1
2023
Statut:
epublish
Résumé
Colorectal cancer is a highly heterogeneous disease. Most colorectal cancers are classical adenocarcinoma, and mucinous adenocarcinoma is a unique histological subtype that is known to respond poorly to chemoradiotherapy. The difference in prognosis between mucinous adenocarcinoma and classical adenocarcinoma is controversial. Here, to gain insight into the differences between classical adenocarcinoma and mucinous adenocarcinoma, we analyse 7 surgical tumour samples from 4 classical adenocarcinoma and 3 mucinous adenocarcinoma patients by single-cell RNA sequencing. Our results indicate that mucinous adenocarcinoma cancer cells have goblet cell-like properties, and express high levels of goblet cell markers (REG4, SPINK4, FCGBP and MUC2) compared to classical adenocarcinoma cancer cells. TFF3 is essential for the transcriptional regulation of these molecules, and may cooperate with RPS4X to eventually lead to the mucinous adenocarcinoma mucus phenotype. The observed molecular characteristics may be critical in the specific biological behavior of mucinous adenocarcinoma.
Identifiants
pubmed: 36690709
doi: 10.1038/s42003-023-04441-w
pii: 10.1038/s42003-023-04441-w
pmc: PMC9870908
doi:
Substances chimiques
Mucins
0
SPINK4 protein, human
0
Serine Peptidase Inhibitors, Kazal Type
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
85Informations de copyright
© 2023. The Author(s).
Références
Nucleic Acids Res. 2017 Jul 3;45(W1):W98-W102
pubmed: 28407145
J Exp Med. 2017 Mar 6;214(3):579-596
pubmed: 28232471
Cancers (Basel). 2021 Mar 04;13(5):
pubmed: 33806447
Cell Death Dis. 2018 Nov 19;9(12):1148
pubmed: 30451832
Int J Colorectal Dis. 2014 May;29(5):563-9
pubmed: 24425620
Gastroenterology. 2005 Nov;129(5):1581-91
pubmed: 16285957
Nat Protoc. 2020 Apr;15(4):1484-1506
pubmed: 32103204
Cancer. 2019 Jul 15;125(14):2465-2473
pubmed: 30951202
Nat Biotechnol. 2011 Nov 13;29(12):1120-7
pubmed: 22081019
Nat Rev Cancer. 2017 Aug 24;17(9):557-569
pubmed: 28835719
Front Oncol. 2020 Jun 09;10:917
pubmed: 32582557
Arch Pathol Lab Med. 2001 Mar;125(3):386-90
pubmed: 11231488
J Clin Pathol. 2012 May;65(5):381-8
pubmed: 22259177
Oncogene. 2016 Oct 6;35(40):5237-5247
pubmed: 26973250
Nat Commun. 2020 Nov 20;11(1):5912
pubmed: 33219235
Mol Cancer. 2015 Jun 10;14:117
pubmed: 26054853
PLoS One. 2011;6(5):e20334
pubmed: 21629776
Front Microbiol. 2018 Jan 15;8:2686
pubmed: 29379481
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Front Immunol. 2020 Sep 04;11:2054
pubmed: 33013869
J Proteome Res. 2009 Jul;8(7):3549-57
pubmed: 19432394
Cancers (Basel). 2020 Oct 27;12(11):
pubmed: 33121034
Science. 2017 Mar 31;355(6332):
pubmed: 28360267
J Trauma Acute Care Surg. 2015 Jan;78(1):94-9
pubmed: 25539208
Ann Surg Oncol. 2014 Sep;21(9):2963-70
pubmed: 24728741
Surgery. 2014 Jun;155(6):1062-8
pubmed: 24856126
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Ann Surg Oncol. 2008 May;15(5):1429-39
pubmed: 18301950
Br J Cancer. 2005 Jan 31;92(2):259-64
pubmed: 15655543
Cell Physiol Biochem. 2005;15(1-4):29-40
pubmed: 15665513
Biochem Biophys Res Commun. 2013 Aug 2;437(3):397-402
pubmed: 23831470
Medicine (Baltimore). 2015 Apr;94(15):e658
pubmed: 25881840
Cancer Discov. 2019 Aug;9(8):1102-1123
pubmed: 31197017
Nat Methods. 2017 Mar;14(3):309-315
pubmed: 28114287
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Sci Rep. 2017 Jul 7;7(1):4915
pubmed: 28687755
Sci Adv. 2021 Oct;7(40):eabg1695
pubmed: 34597139
Nat Methods. 2019 Dec;16(12):1289-1296
pubmed: 31740819
Bioinformatics. 2018 Sep 1;34(17):i884-i890
pubmed: 30423086
Nat Biotechnol. 2015 Mar;33(3):306-12
pubmed: 25485619
Natl Sci Rev. 2020 Aug 24;8(3):nwaa180
pubmed: 34691592
Nat Cell Biol. 2018 Jun;20(6):721-734
pubmed: 29802404
Autophagy. 2012 Dec;8(12):1811-21
pubmed: 23051914
Science. 2014 Jun 20;344(6190):1396-401
pubmed: 24925914
J Leukoc Biol. 1996 Jan;59(1):67-74
pubmed: 8558070
Top Curr Chem. 2015;366:97-137
pubmed: 23842869
Nature. 2019 Mar;567(7746):49-55
pubmed: 30814735
Cell. 2019 Nov 14;179(5):1160-1176.e24
pubmed: 31730855
J Immunol. 1996 Dec 15;157(12):5613-26
pubmed: 8955214
Stem Cell Res Ther. 2015 May 01;6:87
pubmed: 25928089
Cell Signal. 2019 Feb;54:69-80
pubmed: 30465827
Pathology. 2021 Jun;53(4):454-461
pubmed: 33461799
J Proteome Res. 2010 Jun 4;9(6):3108-17
pubmed: 20423149
J Cell Biochem. 2018 Jun;119(6):4717-4728
pubmed: 29274284
Cancer Lett. 2016 Sep 28;380(1):272-80
pubmed: 26546872
Nat Rev Cancer. 2016 Aug 23;16(9):582-98
pubmed: 27550820
Ann Oncol. 2013 Nov;24(11):2819-24
pubmed: 24057984
Histol Histopathol. 2010 Apr;25(4):473-84
pubmed: 20183800
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
World J Gastroenterol. 2013 Jul 7;19(25):3957-68
pubmed: 23840140
Br J Cancer. 2015 Jun 30;113(1):1-5
pubmed: 26110974
Mayo Clin Proc. 2014 Feb;89(2):216-24
pubmed: 24393412
Mol Cancer Ther. 2014 Feb;13(2):528-39
pubmed: 24170770
Curr Med Chem. 2021;28(36):7387-7399
pubmed: 33588719
Cell. 2020 Apr 16;181(2):442-459.e29
pubmed: 32302573
Cell Metab. 2017 Nov 7;26(5):788-800.e6
pubmed: 28889950
Nat Protoc. 2020 Jul;15(7):2247-2276
pubmed: 32561888
Nature. 2012 Jul 18;487(7407):330-7
pubmed: 22810696
Theranostics. 2021 Jan 1;11(4):1626-1640
pubmed: 33408771
Nature. 2018 Dec;564(7735):268-272
pubmed: 30479382
FEBS J. 2018 Aug;285(16):2944-2971
pubmed: 29637711
Int Immunopharmacol. 2021 Mar;92:107304
pubmed: 33513463
Cancer Cell. 2020 Dec 14;38(6):818-828.e5
pubmed: 33096021
Science. 2016 Apr 8;352(6282):189-96
pubmed: 27124452
Nature. 2018 Apr;556(7702):457-462
pubmed: 29643510
Cancer Cell. 2020 Nov 9;38(5):716-733.e6
pubmed: 32946775
J Pathol Clin Res. 2014 Nov 05;1(1):3-17
pubmed: 27499889
Science. 2007 Nov 16;318(5853):1108-13
pubmed: 17932254
Am J Surg Pathol. 1981 Apr;5(3):213-24
pubmed: 7235117
Medicina (Kaunas). 2021 Sep 05;57(9):
pubmed: 34577861
Int J Mol Sci. 2021 May 06;22(9):
pubmed: 34066339
Int J Cancer. 2003 Jan 10;103(2):185-93
pubmed: 12455032
Biochem J. 2009 May 13;420(2):211-9
pubmed: 19228118
Cell Syst. 2021 May 19;12(5):446-456.e9
pubmed: 33951459
Nat Biotechnol. 2015 May;33(5):495-502
pubmed: 25867923