Starch intake, amylase gene copy number variation, plasma proteins, and risk of cardiovascular disease and mortality.
AMY1
Cardiovascular disease
Mortality
Plasma proteins
Starch
Journal
BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723
Informations de publication
Date de publication:
24 Jan 2023
24 Jan 2023
Historique:
received:
01
08
2022
accepted:
12
12
2022
entrez:
23
1
2023
pubmed:
24
1
2023
medline:
26
1
2023
Statut:
epublish
Résumé
Salivary amylase, encoded by the AMY1 gene, initiate the digestion of starch. Whether starch intake or AMY1 copy number is related to disease risk is currently rather unknown. The aim was to investigate the association between starch intake and AMY1 copy number and risk of cardiovascular disease (CVD) and mortality and whether there is an interaction. In addition, we aim to identify CVD-related plasma proteins associated with starch intake and AMY1 copy number. This prospective cohort study used data from 21,268 participants from the Malmö Diet and Cancer Study. Dietary data were collected through a modified diet history method and incident CVD and mortality were ascertained through registers. AMY1 gene copy number was determined by droplet digital polymerase chain reaction, a risk score of 10 genetic variants in AMY1 was measured, and a total of 88 selected CVD-related proteins were measured. Cox proportional hazards regression was used to analyze the associations of starch intake and AMY1 copy number with disease risk. Linear regression was used to identify plasma proteins associated with starch intake and AMY1 copy number. Over a median of 23 years' follow-up, 4443 individuals developed CVD event and 8125 died. After adjusting for potential confounders, a U-shape association between starch intake and risk of CVD (P-nonlinearity = 0.001) and all-cause mortality (P-nonlinearity = 0.03) was observed. No significant association was found between AMY1 copy number and risk of CVD and mortality, and there were no interactions between starch intake and AMY1 copy number (P interaction > 0.23). Among the 88 plasma proteins, adrenomedullin, interleukin-1 receptor antagonist protein, fatty acid-binding protein, leptin, and C-C motif chemokine 20 were associated with starch intake after adjusting for multiple testing. In this large prospective study among Swedish adults, a U-shaped association between starch intake and risk of CVD and all-cause mortality was found. Several plasma proteins were identified which might provide information on potential pathways for such association. AMY1 copy number was not associated with CVD risk or any of the plasma proteins, and there was no interaction between starch intake and AMY1 copy number on disease risk.
Sections du résumé
BACKGROUND
BACKGROUND
Salivary amylase, encoded by the AMY1 gene, initiate the digestion of starch. Whether starch intake or AMY1 copy number is related to disease risk is currently rather unknown. The aim was to investigate the association between starch intake and AMY1 copy number and risk of cardiovascular disease (CVD) and mortality and whether there is an interaction. In addition, we aim to identify CVD-related plasma proteins associated with starch intake and AMY1 copy number.
METHODS
METHODS
This prospective cohort study used data from 21,268 participants from the Malmö Diet and Cancer Study. Dietary data were collected through a modified diet history method and incident CVD and mortality were ascertained through registers. AMY1 gene copy number was determined by droplet digital polymerase chain reaction, a risk score of 10 genetic variants in AMY1 was measured, and a total of 88 selected CVD-related proteins were measured. Cox proportional hazards regression was used to analyze the associations of starch intake and AMY1 copy number with disease risk. Linear regression was used to identify plasma proteins associated with starch intake and AMY1 copy number.
RESULTS
RESULTS
Over a median of 23 years' follow-up, 4443 individuals developed CVD event and 8125 died. After adjusting for potential confounders, a U-shape association between starch intake and risk of CVD (P-nonlinearity = 0.001) and all-cause mortality (P-nonlinearity = 0.03) was observed. No significant association was found between AMY1 copy number and risk of CVD and mortality, and there were no interactions between starch intake and AMY1 copy number (P interaction > 0.23). Among the 88 plasma proteins, adrenomedullin, interleukin-1 receptor antagonist protein, fatty acid-binding protein, leptin, and C-C motif chemokine 20 were associated with starch intake after adjusting for multiple testing.
CONCLUSIONS
CONCLUSIONS
In this large prospective study among Swedish adults, a U-shaped association between starch intake and risk of CVD and all-cause mortality was found. Several plasma proteins were identified which might provide information on potential pathways for such association. AMY1 copy number was not associated with CVD risk or any of the plasma proteins, and there was no interaction between starch intake and AMY1 copy number on disease risk.
Identifiants
pubmed: 36691017
doi: 10.1186/s12916-022-02706-5
pii: 10.1186/s12916-022-02706-5
pmc: PMC9872432
doi:
Substances chimiques
Starch
9005-25-8
Amylases
EC 3.2.1.-
Salivary alpha-Amylases
EC 3.2.1.1
Blood Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
27Subventions
Organisme : Riksförbundet HjärtLung
ID : 20190555
Organisme : Crafoordska Stiftelsen
ID : 20201032
Informations de copyright
© 2023. The Author(s).
Références
Hum Mol Genet. 2015 Jun 15;24(12):3472-80
pubmed: 25788522
Cell Metab. 2005 Feb;1(2):107-19
pubmed: 16054052
Crit Rev Food Sci Nutr. 2020;60(7):1063-1076
pubmed: 30638040
Nat Genet. 2007 Oct;39(10):1256-60
pubmed: 17828263
Arch Intern Med. 2010 Apr 12;170(7):640-7
pubmed: 20386010
Eur J Clin Nutr. 1996 Mar;50(3):143-51
pubmed: 8654327
Diabetes Metab Syndr Obes. 2020 May 19;13:1695-1701
pubmed: 32547131
Mol Nutr Food Res. 2020 Jun;64(11):e1901151
pubmed: 32378791
Eur J Clin Nutr. 2007 May;61(5):575-81
pubmed: 17136037
Hormones (Athens). 2020 Sep;19(3):369-376
pubmed: 32405930
Mol Nutr Food Res. 2021 Sep;65(18):e2170044
pubmed: 34549876
J Clin Endocrinol Metab. 2002 Mar;87(3):1184-8
pubmed: 11889184
Microbes Infect. 2014 Oct;16(10):864-70
pubmed: 25130722
BMJ. 2016 Jun 14;353:i2716
pubmed: 27301975
Dig Dis Sci. 1987 Oct;32(10):1097-103
pubmed: 3652896
Nat Genet. 2015 Aug;47(8):921-5
pubmed: 26098870
BMC Med. 2020 Apr 24;18(1):97
pubmed: 32326961
Heart. 2022 May 25;108(12):932-939
pubmed: 34509998
J Leukoc Biol. 2000 Oct;68(4):437-46
pubmed: 11037963
Lancet. 2019 Feb 2;393(10170):434-445
pubmed: 30638909
BMJ. 2012 Jun 26;344:e4026
pubmed: 22735105
Food Nutr Res. 2018 Aug 28;62:
pubmed: 30186087
Public Health Nutr. 2017 Feb;20(2):233-244
pubmed: 27577106
J Nutr. 2012 May;142(5):853-8
pubmed: 22492122
Metabolism. 2000 Jun;49(6):764-9
pubmed: 10877204
Am J Clin Nutr. 2018 Feb 1;107(2):257-267
pubmed: 29529162
Int J Epidemiol. 1997;26 Suppl 1:S161-73
pubmed: 9126544
Asia Pac J Clin Nutr. 2021 Dec;30(4):614-623
pubmed: 34967190
Eur J Clin Nutr. 1996 Mar;50(3):134-42
pubmed: 8654326
BMJ. 2020 Mar 18;368:m688
pubmed: 32188587
Am J Clin Nutr. 2000 Jun;71(6):1455-61
pubmed: 10837285
Br J Nutr. 2019 Oct 14;122(7):820-828
pubmed: 32124712
N Engl J Med. 1999 Sep 16;341(12):879-84
pubmed: 10486419
PLoS One. 2013 May 23;8(5):e62625
pubmed: 23717392
Am J Clin Nutr. 2014 Jul;100(1):53-64
pubmed: 24787492
Stat Med. 2010 Apr 30;29(9):1037-57
pubmed: 20087875
J Clin Med. 2019 Mar 19;8(3):
pubmed: 30893908
Lancet. 2017 Nov 4;390(10107):2050-2062
pubmed: 28864332
Am J Clin Nutr. 2018 Oct 1;108(4):737-748
pubmed: 30239565
Front Nutr. 2021 Jan 07;7:598850
pubmed: 33490099
PLoS One. 2014 Sep 22;9(9):e107487
pubmed: 25244011
Eur J Cancer Prev. 2001 Dec;10(6):489-99
pubmed: 11916347
Diabetes Care. 2019 Aug;42(8):1582-1588
pubmed: 31201260
Nutr Res. 2009 Feb;29(2):100-5
pubmed: 19285600
Nutrients. 2021 Jun 06;13(6):
pubmed: 34204127
Nutrients. 2022 Mar 16;14(6):
pubmed: 35334910
Am J Clin Nutr. 2017 Jul;106(1):256-262
pubmed: 28539377
PLoS One. 2010 Oct 13;5(10):e13352
pubmed: 20967220
Curr Opin Nephrol Hypertens. 2004 Mar;13(2):215-23
pubmed: 15202616
BMC Public Health. 2011 Jun 09;11:450
pubmed: 21658213
Stroke. 1992 Mar;23(3):357-61
pubmed: 1542896
Nutrients. 2011 Mar;3(3):341-69
pubmed: 22254101
J Am Coll Cardiol. 2018 Aug 21;72(8):914-926
pubmed: 30115231
Cardiovasc Diabetol. 2011 Apr 17;10:34
pubmed: 21496338
Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L227-L240
pubmed: 29696987
Am J Clin Nutr. 2010 Oct;92(4):967-74
pubmed: 20826627