Digital twin demonstrates significance of biomechanical growth control in liver regeneration after partial hepatectomy.
Tissue engineering
mathematical biosciences
systems biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 Jan 2023
20 Jan 2023
Historique:
received:
01
03
2021
revised:
23
06
2022
accepted:
29
11
2022
entrez:
24
1
2023
pubmed:
25
1
2023
medline:
25
1
2023
Statut:
epublish
Résumé
Partial liver removal is an important therapy option for liver cancer. In most patients within a few weeks, the liver is able to fully regenerate. In some patients, however, regeneration fails with often severe consequences. To better understand the control mechanisms of liver regeneration, experiments in mice were performed, guiding the creation of a spatiotemporal 3D model of the regenerating liver. The model represents cells and blood vessels within an entire liver lobe, a macroscopic liver subunit. The model could reproduce the experimental data only if a biomechanical growth control (BGC)-mechanism, inhibiting cell cycle entrance at high compression, was taken into account and predicted that BGC may act as a short-range growth inhibitor minimizing the number of proliferating neighbor cells of a proliferating cell, generating a checkerboard-like proliferation pattern. Model-predicted cell proliferation patterns in pigs and mice were found experimentally. The results underpin the importance of biomechanical aspects in liver growth control.
Identifiants
pubmed: 36691615
doi: 10.1016/j.isci.2022.105714
pii: S2589-0042(22)01987-3
pmc: PMC9860368
doi:
Types de publication
Journal Article
Langues
eng
Pagination
105714Informations de copyright
© 2022.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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