ParA's Impact beyond Chromosome Segregation in Caulobacter crescentus.
Caulobacter
DnaA
ParA
cell cycle
cell length
chromosome replication
chromosome segregation
Journal
Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R
Informations de publication
Date de publication:
22 02 2023
22 02 2023
Historique:
pubmed:
25
1
2023
medline:
3
3
2023
entrez:
24
1
2023
Statut:
ppublish
Résumé
Maintaining proper chromosome inheritance after the completion of each cell cycle is paramount for bacterial survival. Mechanistic details remain incomplete for how bacteria manage to retain complete chromosomes after each cell cycle. In this study, we examined the potential roles of the partitioning protein ParA on chromosomal maintenance that go beyond triggering the onset of chromosome segregation in Caulobacter crescentus. Our data revealed that increasing the levels of ParA result in cells with multiple origins of replication in a DnaA-ATP-dependent manner. This
Identifiants
pubmed: 36692299
doi: 10.1128/jb.00296-22
pmc: PMC9945499
doi:
Substances chimiques
Bacterial Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0029622Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM133833
Pays : United States