Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1-Nitropyrene via Nitroreduction in Human Lung Cells.
Journal
Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448
Informations de publication
Date de publication:
20 02 2023
20 02 2023
Historique:
pmc-release:
20
02
2024
pubmed:
25
1
2023
medline:
25
2
2023
entrez:
24
1
2023
Statut:
ppublish
Résumé
1-Nitropyrene (1-NP) is a constituent of diesel exhaust and classified as a group 2A probable human carcinogen. The metabolic activation of 1-NP by nitroreduction generates electrophiles that can covalently bind DNA to form mutations to contribute to cancer causation. NADPH-dependent P450 oxidoreductase (POR), xanthine oxidase (XO), aldehyde oxidase (AOX), and NAD(P)H/quinone oxidoreductase 1 (NQO1) may catalyze 1-NP nitroreduction. We recently found that human recombinant aldo-keto reductases (AKRs) 1C1-1C3 catalyze 1-NP nitroreduction.
Identifiants
pubmed: 36693016
doi: 10.1021/acs.chemrestox.2c00337
pmc: PMC9974908
mid: NIHMS1871388
doi:
Substances chimiques
1-nitropyrene
TD1665I8Q4
Aldo-Keto Reductases
EC 1.1.1.-
NF-E2-Related Factor 2
0
Vehicle Emissions
0
NFE2L2 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
270-280Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029294
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES019851
Pays : United States
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