Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1-Nitropyrene via Nitroreduction in Human Lung Cells.


Journal

Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448

Informations de publication

Date de publication:
20 02 2023
Historique:
pmc-release: 20 02 2024
pubmed: 25 1 2023
medline: 25 2 2023
entrez: 24 1 2023
Statut: ppublish

Résumé

1-Nitropyrene (1-NP) is a constituent of diesel exhaust and classified as a group 2A probable human carcinogen. The metabolic activation of 1-NP by nitroreduction generates electrophiles that can covalently bind DNA to form mutations to contribute to cancer causation. NADPH-dependent P450 oxidoreductase (POR), xanthine oxidase (XO), aldehyde oxidase (AOX), and NAD(P)H/quinone oxidoreductase 1 (NQO1) may catalyze 1-NP nitroreduction. We recently found that human recombinant aldo-keto reductases (AKRs) 1C1-1C3 catalyze 1-NP nitroreduction.

Identifiants

pubmed: 36693016
doi: 10.1021/acs.chemrestox.2c00337
pmc: PMC9974908
mid: NIHMS1871388
doi:

Substances chimiques

1-nitropyrene TD1665I8Q4
Aldo-Keto Reductases EC 1.1.1.-
NF-E2-Related Factor 2 0
Vehicle Emissions 0
NFE2L2 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

270-280

Subventions

Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029294
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES019851
Pays : United States

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Auteurs

Anthony L Su (AL)

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Trevor M Penning (TM)

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

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Classifications MeSH