Age-related changes in gait biomechanics and their impact on the metabolic cost of walking: Report from a National Institute on Aging workshop.
Fatigue
Mobility
Muscle energetics
Tendon
Wearable technology
Journal
Experimental gerontology
ISSN: 1873-6815
Titre abrégé: Exp Gerontol
Pays: England
ID NLM: 0047061
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
12
10
2022
revised:
09
01
2023
accepted:
19
01
2023
pmc-release:
01
03
2024
pubmed:
25
1
2023
medline:
25
2
2023
entrez:
24
1
2023
Statut:
ppublish
Résumé
Changes in old age that contribute to the complex issue of an increased metabolic cost of walking (mass-specific energy cost per unit distance traveled) in older adults appear to center at least in part on changes in gait biomechanics. However, age-related changes in energy metabolism, neuromuscular function and connective tissue properties also likely contribute to this problem, of which the consequences are poor mobility and increased risk of inactivity-related disease and disability. The U.S. National Institute on Aging convened a workshop in September 2021 with an interdisciplinary group of scientists to address the gaps in research related to the mechanisms and consequences of changes in mobility in old age. The goal of the workshop was to identify promising ways to move the field forward toward improving gait performance, decreasing energy cost, and enhancing mobility for older adults. This report summarizes the workshop and brings multidisciplinary insight into the known and potential causes and consequences of age-related changes in gait biomechanics. We highlight how gait mechanics and energy cost change with aging, the potential neuromuscular mechanisms and role of connective tissue in these changes, and cutting-edge interventions and technologies that may be used to measure and improve gait and mobility in older adults. Key gaps in the literature that warrant targeted research in the future are identified and discussed.
Identifiants
pubmed: 36693530
pii: S0531-5565(23)00023-2
doi: 10.1016/j.exger.2023.112102
pmc: PMC10008437
mid: NIHMS1871621
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
112102Subventions
Organisme : Intramural NIH HHS
ID : Z99 AG999999
Pays : United States
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Références
J Appl Physiol (1985). 2022 Oct 1;133(4):850-866
pubmed: 35952347
Exerc Sport Sci Rev. 2009 Jul;37(3):130-8
pubmed: 19550204
Nat Biomed Eng. 2021 Dec;5(12):1457-1471
pubmed: 34031557
J Biomech. 2020 Nov 9;112:110067
pubmed: 33035839
Sci Rep. 2019 Apr 3;9(1):5568
pubmed: 30944360
J Neuroeng Rehabil. 2019 Oct 15;16(1):117
pubmed: 31615535
Gait Posture. 2022 Jan;91:111-116
pubmed: 34673446
Gait Posture. 2013 Jun;38(2):253-9
pubmed: 23267819
J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):996-1002
pubmed: 25733719
J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):539-545
pubmed: 28977366
J Appl Biomech. 2020 Apr 25;:1-8
pubmed: 32335528
J Physiol. 2008 Jan 1;586(1):11-23
pubmed: 17702815
Physiology (Bethesda). 2019 Nov 1;34(6):402-408
pubmed: 31577172
J Neuroeng Rehabil. 2014 Nov 03;11:151
pubmed: 25367552
Am J Geriatr Psychiatry. 2011 Jun;19(6):571-80
pubmed: 21606900
BMJ. 2010 Sep 09;341:c4467
pubmed: 20829298
Br J Nutr. 2012 Apr;107(7):1085-91
pubmed: 21810289
J Appl Physiol (1985). 2008 Dec;105(6):1907-15
pubmed: 18927271
Sci Rep. 2019 Jul 10;9(1):9956
pubmed: 31292471
Gait Posture. 2020 Mar;77:89-94
pubmed: 32004951
Am J Phys Med Rehabil. 2017 Dec;96(12):894-903
pubmed: 29176406
Obesity (Silver Spring). 2006 Mar;14(3):345-56
pubmed: 16648603
Front Physiol. 2020 Jun 18;11:626
pubmed: 32625114
Appl Physiol Nutr Metab. 2012 Feb;37(1):88-99
pubmed: 22236246
J Biomech Eng. 2003 Feb;125(1):70-7
pubmed: 12661198
J Physiol. 2007 Sep 15;583(Pt 3):1093-105
pubmed: 17673506
Sensors (Basel). 2020 Aug 26;20(17):
pubmed: 32858833
J Appl Physiol (1985). 2000 May;88(5):1804-11
pubmed: 10797145
Cell. 2014 Nov 6;159(4):709-13
pubmed: 25417146
J Physiol. 2003 May 1;548(Pt 3):971-81
pubmed: 12626673
Ageing Res Rev. 2013 Mar;12(2):618-27
pubmed: 23501431
PLoS Comput Biol. 2019 Oct 7;15(10):e1006993
pubmed: 31589597
J Appl Physiol (1985). 2006 Jun;100(6):2048-56
pubmed: 16455811
J Gerontol A Biol Sci Med Sci. 2022 Apr 1;77(4):781-789
pubmed: 34407184
Compr Physiol. 2012 Apr;2(2):997-1044
pubmed: 23798294
Neurorehabil Neural Repair. 2018 Aug;32(8):701-713
pubmed: 29998788
Ann Phys Rehabil Med. 2016 Apr;59(2):114-24
pubmed: 26969343
J Appl Physiol (1985). 2005 Sep;99(3):986-94
pubmed: 15860680
Gait Posture. 2012 May;36(1):102-7
pubmed: 22459093
J Gerontol A Biol Sci Med Sci. 2011 May;66(5):541-7
pubmed: 21345892
J Appl Physiol (1985). 2018 Jul 1;125(1):146-158
pubmed: 29494293
Exerc Sport Sci Rev. 2011 Apr;39(2):59-67
pubmed: 21206279
Exp Gerontol. 2021 May;147:111275
pubmed: 33556533
Age Ageing. 2011 Jan;40(1):14-23
pubmed: 20843964
Med Sci Sports Exerc. 2011 Apr;43(4):568-77
pubmed: 20881888
J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1811-1820
pubmed: 35415973
J Am Med Dir Assoc. 2018 Jun;19(6):484-491.e3
pubmed: 29680203
J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1641-1652
pubmed: 34708570
J Neuroeng Rehabil. 2020 Feb 19;17(1):25
pubmed: 32075669
Sci Transl Med. 2021 Feb 24;13(582):
pubmed: 33627488
IEEE Trans Neural Syst Rehabil Eng. 2021;29:1386-1393
pubmed: 34252030
Front Hum Neurosci. 2019 Jun 18;13:194
pubmed: 31316360
J Anat. 2007 Sep;211(3):325-34
pubmed: 17848160
J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):947-53
pubmed: 26850913
J Aging Phys Act. 2019 Apr 1;27(2):242-251
pubmed: 30117347
J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1184-94
pubmed: 26975983
Am J Physiol Regul Integr Comp Physiol. 2014 Nov 1;307(9):R1124-35
pubmed: 25163917
J Biomech. 2018 Aug 22;77:34-39
pubmed: 29945784
Wearable Technol. 2022;3:
pubmed: 36404993
PLoS One. 2013;8(2):e56013
pubmed: 23405245
Front Genet. 2020 Jan 16;10:1338
pubmed: 32010194
Sensors (Basel). 2020 Nov 14;20(22):
pubmed: 33202589
Epidemiol Rev. 2013;35:51-65
pubmed: 23221972
J Neuropathol Exp Neurol. 2014 Apr;73(4):284-94
pubmed: 24607961
Exp Gerontol. 2012 Jan;47(1):85-92
pubmed: 22079852
Acta Physiol (Oxf). 2007 Jan;189(1):57-65
pubmed: 17280557
Gait Posture. 2012 May;36(1):149-53
pubmed: 22445586
Exp Gerontol. 2014 Jul;55:49-53
pubmed: 24703887
Ageing Res Rev. 2022 Sep;80:101698
pubmed: 35853549
J Exp Biol. 2017 Jun 01;220(Pt 11):2082-2095
pubmed: 28341663
Gait Posture. 2016 Oct;50:131-136
pubmed: 27607304
Sci Transl Med. 2022 Jun;14(647):eabj5557
pubmed: 35648809
J Electromyogr Kinesiol. 2015 Feb;25(1):193-8
pubmed: 25263547
JAMA. 2011 Jan 5;305(1):50-8
pubmed: 21205966
Circulation. 2020 Mar 3;141(9):e139-e596
pubmed: 31992061
J Physiol. 2018 Apr 1;596(7):1199-1210
pubmed: 29344967
N C Med J. 2007 Nov-Dec;68(6):459-62
pubmed: 18236871
Arch Gerontol Geriatr. 2013 Sep-Oct;57(2):192-7
pubmed: 23561852
Gait Posture. 2019 Jun;71:44-49
pubmed: 31005854
J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1316-1329
pubmed: 31419087
J Appl Physiol (1985). 2016 Oct 1;121(4):982-995
pubmed: 27516536
Biol Lett. 2017 Jan;13(1):
pubmed: 28123108
Sensors (Basel). 2022 Feb 18;22(4):
pubmed: 35214491
Gait Posture. 2010 Mar;31(3):355-9
pubmed: 20106666
Gait Posture. 2009 Jun;29(4):558-64
pubmed: 19147360
Aging Cell. 2022 Feb;21(2):e13552
pubmed: 35048491
PM R. 2010 May;2(5):406-13
pubmed: 20656622
Am J Clin Nutr. 2009 Dec;90(6):1579-85
pubmed: 19864405
J Appl Physiol (1985). 1992 Jul;73(1):200-6
pubmed: 1506370
J Am Geriatr Soc. 2010 May;58(5):967-75
pubmed: 20722821
Curr Transl Geriatr Exp Gerontol Rep. 2013 Dec;2(4):
pubmed: 24319641
Comput Methods Biomech Biomed Engin. 2021 Nov;24(14):1552-1565
pubmed: 33749464
Nature. 2015 Jun 11;522(7555):212-5
pubmed: 25830889
Gait Posture. 2014 Jan;39(1):135-40
pubmed: 23850328
J Biomech. 2016 Jun 14;49(9):1403-1410
pubmed: 27209552
Am J Clin Nutr. 2013 Mar;97(3):552-60
pubmed: 23364001
Gerontology. 2022;68(3):241-251
pubmed: 34274923
J Am Geriatr Soc. 2016 Jun;64(6):1287-92
pubmed: 27253228
J Appl Physiol (1985). 2011 Nov;111(5):1345-52
pubmed: 21868683
Gait Posture. 2013 Mar;37(3):378-84
pubmed: 22940542
Exp Physiol. 2006 Mar;91(2):371-82
pubmed: 16407475
Physiother Can. 2009 Fall;61(4):197-209
pubmed: 20808481
IEEE Trans Neural Syst Rehabil Eng. 2019 Jul;27(7):1426-1435
pubmed: 31199264
Ann Biomed Eng. 2012 May;40(5):1088-101
pubmed: 22187136
Ann N Y Acad Sci. 1988;515:18-32
pubmed: 3364884
Exp Gerontol. 2016 Jul;80:12-6
pubmed: 27086065
Gerontology. 2021;67(4):403-414
pubmed: 33657562
Scand J Med Sci Sports. 2000 Dec;10(6):368-71
pubmed: 11085566
Front Physiol. 2020 May 19;11:495
pubmed: 32508678
J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1638-1645
pubmed: 27075894
J Sports Sci. 2016 Aug;34(15):1388-95
pubmed: 26588262
PLoS One. 2013;8(2):e56137
pubmed: 23418524
Aging Cell. 2017 Jun;16(3):461-468
pubmed: 28181388
Gait Posture. 2010 Jul;32(3):378-82
pubmed: 20655750
Gait Posture. 2019 May;70:24-29
pubmed: 30784958
Med Eng Phys. 2019 Feb;64:86-92
pubmed: 30581048
Appl Physiol Nutr Metab. 2016 Nov;41(11):1137-1145
pubmed: 27779429
J Appl Physiol (1985). 2016 Dec 1;121(6):1237-1246
pubmed: 27150831
Curr Opin Clin Nutr Metab Care. 2013 Jan;16(1):21-6
pubmed: 23222705
Geroscience. 2021 Aug;43(4):1567-1584
pubmed: 34196903
Aging Cell. 2021 Nov;20(11):e13487
pubmed: 34612579
J Physiol. 2021 Jun;599(12):3063-3080
pubmed: 33876434
J Physiol. 2019 Oct;597(19):4943-4957
pubmed: 31018011
Exp Gerontol. 2017 Sep;95:63-70
pubmed: 28499954
Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1772-1778
pubmed: 31879350
Exp Gerontol. 2020 Aug;137:110966
pubmed: 32360339
Front Neurol. 2016 Dec 19;7:231
pubmed: 28066316
Neurorehabil Neural Repair. 2021 Aug;35(8):738-749
pubmed: 34060926
J Am Geriatr Soc. 2012 Oct;60(10):1811-6
pubmed: 23035640
PLoS Comput Biol. 2022 Sep 9;18(9):e1010466
pubmed: 36084139
J Gerontol A Biol Sci Med Sci. 2003 Aug;58(8):728-33
pubmed: 12902531
N Engl J Med. 1995 Mar 2;332(9):556-61
pubmed: 7838189
Aging Cell. 2020 Apr;19(4):e13124
pubmed: 32196924
Scand J Med Sci Sports. 2021 May;31(5):1036-1047
pubmed: 33527504
J Appl Physiol (1985). 2012 Nov;113(10):1537-44
pubmed: 23042907