Cognitive performance is associated with glomerular filtration rate in patients with chronic kidney disease: results from the CKD-REIN cohort.


Journal

Journal of neurology, neurosurgery, and psychiatry
ISSN: 1468-330X
Titre abrégé: J Neurol Neurosurg Psychiatry
Pays: England
ID NLM: 2985191R

Informations de publication

Date de publication:
06 2023
Historique:
received: 06 09 2022
accepted: 05 01 2023
medline: 17 5 2023
pubmed: 25 1 2023
entrez: 24 1 2023
Statut: ppublish

Résumé

Chronic kidney disease (CKD) is associated with cognitive impairment in general population. We assessed the association between kidney and cognitive functions in patients with CKD and the influence of cardiovascular (CV) risk factors, and depression on this association. The CKD-Renal Epidemiology and Information Network cohort included 3033 patients with CKD stages 3-4, followed for 5 years. Cognitive function was assessed with the Mini-Mental State Examination (MMSE) and estimated glomerular filtration rate (eGFR) with the CKD-Epidemiology Collaboration equation-creatinin formula. Evolution of the MMSE score over time and its association with baseline eGFR were investigated with linear mixed models. We assessed the risk of incident cognitive outcome (hospitalisation or death with relevant International Classification of Disease-10 codes), with a Cox proportional hazard model. The mean age was 66.8, the mean eGFR was 33 mL/min/1.73 m In patients with CKD, lower eGFR was associated with worse cognitive performance and incident cognitive events, independently of demographics, CV risk factors and depression. NCT03381950.

Sections du résumé

BACKGROUND
Chronic kidney disease (CKD) is associated with cognitive impairment in general population. We assessed the association between kidney and cognitive functions in patients with CKD and the influence of cardiovascular (CV) risk factors, and depression on this association.
METHODS
The CKD-Renal Epidemiology and Information Network cohort included 3033 patients with CKD stages 3-4, followed for 5 years. Cognitive function was assessed with the Mini-Mental State Examination (MMSE) and estimated glomerular filtration rate (eGFR) with the CKD-Epidemiology Collaboration equation-creatinin formula. Evolution of the MMSE score over time and its association with baseline eGFR were investigated with linear mixed models. We assessed the risk of incident cognitive outcome (hospitalisation or death with relevant International Classification of Disease-10 codes), with a Cox proportional hazard model.
RESULTS
The mean age was 66.8, the mean eGFR was 33 mL/min/1.73 m
CONCLUSIONS
In patients with CKD, lower eGFR was associated with worse cognitive performance and incident cognitive events, independently of demographics, CV risk factors and depression.
TRIAL REGISTRATION NUMBER
NCT03381950.

Identifiants

pubmed: 36693722
pii: jnnp-2022-330347
doi: 10.1136/jnnp-2022-330347
doi:

Banques de données

ClinicalTrials.gov
['NCT03381950']

Types de publication

Clinical Trial Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

457-466

Investigateurs

Natalia Alencar de Pinho (NA)
Carole Ayav (C)
Christian Combe (C)
Denis Fouque (D)
Luc Frimat (L)
Christian Jacquelinet (C)
Maurice Laville (M)
Sophie Liabeuf (S)
Ziad A Massy (ZA)
Christophe Pascal (C)
Bruce M Robinson (BM)
Roberto Pecoits-Filho (R)
Bénédicte Stengel (B)
Céline Lange (C)
Marie Metzger (M)
Elodie Speyer (E)
T Hannedouche (T)
B Moulin (B)
A Klein (A)
C Combe (C)
J P Bourdenx (JP)
A Keller (A)
C Delclaux (C)
B Vendrely (B)
B Deroure (B)
A Lacraz (A)
T Lobbedez (T)
I Landru (I)
Z Massy (Z)
P Lang (P)
X Belenfant (X)
E Thervet (E)
P Urena (P)
M Delahousse (M)
C Vela (C)
M Essig (M)
D Clément (D)
H Sekhri (H)
M Smati (M)
M Jamali (M)
B Hacq (B)
V Panescu (V)
M Bellou (M)
Luc Frimat (L)
N Kamar (N)
C Noël (C)
F Glowacki (F)
N Maisonneuve (N)
R Azar (R)
M Hoffmann (M)
M Hourmant (M)
A Testa (A)
D Besnier (D)
G Choukroun (G)
G Lambrey (G)
S Burtey (S)
G Lebrun (G)
E Magnant (E)
M Laville (M)
D Fouque (D)
C Chazot (C)
P Zaoui (P)
F Kuentz (F)

Informations de copyright

© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: BS reports grants for the CKD-REIN cohort study from Amgen, AstraZeneca, Baxter, Fresenius Medical Care, GlaxoSmithKline, Merck Sharp and Dohme-Chibret, Sanofi-Genzyme, Lilly, Otsuka, and Vifor France. ZAM reports grants for CKD-REIN and other research projects from Amgen, Baxter, Fresenius Medical Care, GlaxoSmithKline, Merck Sharp and Dohme-Chibret, Sanofi-Genzyme, Lilly, Otsuka and the French government, as well as fees and grants to charities from Astellas, Baxter, Daichii and Sanofi-Genzyme; these sources of funding are not necessarily related to the content of the present manuscript. DF reports grants for other research projects from Fresenius Kabi and Sanofi.The other authors declare that they have no competing interests.

Auteurs

Marion Pépin (M)

Geriatrics, APHP, UVSQ, Hopital Ambroise-Pare, Boulogne-Billancourt, France marion.pepin@aphp.fr.
Clinical Epidemiology, CESP, INSERM, Paris Saclay University, Villejuif, France.

Hélène Levassort (H)

Geriatrics, APHP, UVSQ, Hopital Ambroise-Pare, Boulogne-Billancourt, France.
Clinical Epidemiology, CESP, INSERM, Paris Saclay University, Villejuif, France.
Nephrology, APHP, UVSQ, Hopital Ambroise-Pare, Boulogne-Billancourt, France.

Julie Boucquemont (J)

Clinical Epidemiology, CESP, INSERM, Paris Saclay University, Villejuif, France.

Oriane Lambert (O)

Clinical Epidemiology, CESP, INSERM, Paris Saclay University, Villejuif, France.

Natalia Alencar de Pinho (N)

Clinical Epidemiology, CESP, INSERM, Paris Saclay University, Villejuif, France.

Monica Turinici (M)

Nephrology, APHP, UVSQ, Hopital Ambroise-Pare, Boulogne-Billancourt, France.
LIRAES ED 262, Universite de Paris, Paris, France.

Catherine Helmer (C)

Bordeaux Population Health Center, INSERM U1219, Bordeaux, France.

Marie Metzger (M)

Clinical Epidemiology, CESP, INSERM, Paris Saclay University, Villejuif, France.

Lynda Cheddani (L)

Clinical Epidemiology, CESP, INSERM, Paris Saclay University, Villejuif, France.
Nephrology, APHP, UVSQ, Hopital Ambroise-Pare, Boulogne-Billancourt, France.

Luc Frimat (L)

Nephrology, Lorraine University, CHRU de Nancy, Vandoeuvre, France.
EA 4360, Lorraine University, INSERM CIC-EC, Apemac, France.

Christian Combe (C)

Nephrology, Bordeaux University Hospital, Bordeaux, France.
Biotis, INSERM U1026, Bordeaux, France.

Denis Fouque (D)

Nephrology, Claude Bernard Lyon 1 University, Centre Hospitalier Lyon-Sud, Pierre-Benite, France.

Maurice Laville (M)

Carmen, INSERM U1060, University Claude Bernard Lyon 1, Pierre Benite, France.

Carole Ayav (C)

Clinical Epidemiology, INSERM, Lorraine University, CHRU de Nancy, Nancy, France.

Sophie Liabeuf (S)

Pharmacology, Amiens University, Amiens, France.
MP3CV Laboratory EA7517, Université de Picardie Jules Verne, Amiens, France.

Christian Jacquelinet (C)

Clinical Epidemiology, CESP, INSERM, Paris Saclay University, Villejuif, France.
Medical and Scientific Departement, Agence de la Biomedecine, La Plaine Saint-Denis, France.

Laurent Teillet (L)

Geriatrics, APHP, UVSQ, Hopital Ambroise-Pare, Boulogne-Billancourt, France.
Clinical Epidemiology, CESP, INSERM, Paris Saclay University, Villejuif, France.

Bénédicte Stengel (B)

Clinical Epidemiology, CESP, INSERM, Paris Saclay University, Villejuif, France.

Ziad A Massy (ZA)

Clinical Epidemiology, CESP, INSERM, Paris Saclay University, Villejuif, France.
Nephrology, APHP, UVSQ, Hopital Ambroise-Pare, Boulogne-Billancourt, France.

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