IVF/ICSI Outcomes After a Freeze-All Strategy: an Observational Cohort Study.
Cryopreseservation
Embryo transfer
Endometriosis
In vitro fertilization
Ovarian hyperstimulation syndrome
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
17
05
2022
accepted:
13
01
2023
medline:
3
7
2023
pubmed:
25
1
2023
entrez:
24
1
2023
Statut:
ppublish
Résumé
In order to inform patients undergoing ART regarding their chances for motherhood, it seems useful to describe "freeze all" outcomes according to the different potential indications. The goal of this study was to examine the impact of a "freeze-all approach" on the cumulative live birth rate (cLBR) according to the indication. It is a cohort study including women who had undergone ovarian stimulation (OS) using an antagonist protocol with GnRH agonist triggering between 09.2016 and 09.2018 followed by a freeze-all cycle of blastocyst embryos. The ART outcomes were compared between the two main indications of the freeze-all strategy which were in our cohort: risk of ovarian hyperstimulation syndrome (OHSS) and endometriosis. The ART outcomes were also described for the others indications (inadequate endometrium and/or premature progesterone elevation at trigger day, two or more previous ART failures, and autoimmune disease and/or a high risk of thromboembolic disease (AI and/or TE risk)). In total, 658 women were included. The cLBR in the total population was 37.7% (248/658). The cLBR was significantly higher in the "OHSS risk" group (133/281, 47.3%) than in the "endometriosis" group (69/190, 36.3%) (p = 0.017). No significant differences were noted regarding perinatal outcomes, except a significantly higher risk of placenta praevia (PP) observed in the "endometriosis" group (10.1%) (p = 0.002). The "freeze-all approach" yielded good results in terms of the cLBR and especially in case of OHSS risk. These data should be taken into account when informing patients about the ART strategy and their chances of motherhood.
Identifiants
pubmed: 36694083
doi: 10.1007/s43032-023-01173-4
pii: 10.1007/s43032-023-01173-4
doi:
Substances chimiques
Gonadotropin-Releasing Hormone
33515-09-2
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2283-2291Informations de copyright
© 2023. The Author(s), under exclusive licence to Society for Reproductive Investigation.
Références
European IVF-monitoring Consortium (EIM)‡ for the European Society of Human Reproduction and Embryology (ESHRE), Wyns C, Bergh C, Calhaz-Jorge C, De Geyter C, Kupka MS, et al. ART in Europe, 2016: results generated from European registries by ESHRE. Hum Reprod Open. 2020;2020:hoaa032. https://doi.org/10.1093/hropen/hoaa032 .
doi: 10.1093/hropen/hoaa032
pubmed: 32760812
pmcid: 7394132
Van Landuyt L, Stoop D, Verheyen G, Verpoest W, Camus M, Van de Velde H, et al. Outcome of closed blastocyst vitrification in relation to blastocyst quality: evaluation of 759 warming cycles in a single-embryo transfer policy. Hum Reprod. 2011;26:527–34. https://doi.org/10.1093/humrep/deq374 .
doi: 10.1093/humrep/deq374
pubmed: 21212054
Bodri D, Guillén JJ, Trullenque M, Schwenn K, Esteve C, Coll O. Early ovarian hyperstimulation syndrome is completely prevented by gonadotropin releasing-hormone agonist triggering in high-risk oocyte donor cycles: a prospective, luteal-phase follow-up study. Fertil Steril. 2010;93:2418–20. https://doi.org/10.1016/j.fertnstert.2009.08.036 .
doi: 10.1016/j.fertnstert.2009.08.036
pubmed: 19800620
Bourdon M, Maignien C, Pocate-Cheriet K, Plu Bureau G, Marcellin L, Patrat C, et al. The freeze-all strategy after IVF: which indications? Reprod Biomed Online. 2021;42(3):529–45. https://doi.org/10.1016/j.rbmo.2020.11.013 .
doi: 10.1016/j.rbmo.2020.11.013
pubmed: 33384269
Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, et al. Transfer of fresh versus frozen embryos in ovulatory women. N Engl J Med. 2018;378:126–36. https://doi.org/10.1056/NEJMoa1705334 .
doi: 10.1056/NEJMoa1705334
pubmed: 29320646
Wei D, Liu J-Y, Sun Y, Shi Y, Zhang B, Liu J-Q, et al. Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial. Lancet. 2019. https://doi.org/10.1016/S0140-6736(18)32843-5 .
doi: 10.1016/S0140-6736(18)32843-5
pubmed: 31777387
pmcid: 8006904
Chen Z-J, Shi Y, Sun Y, Zhang B, Liang X, Cao Y, et al. Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med. 2016;375:523–33. https://doi.org/10.1056/NEJMoa1513873 .
doi: 10.1056/NEJMoa1513873
pubmed: 27509101
Roque M, Haahr T, Geber S, Esteves SC, Humaidan P. Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes. Hum Reprod Update. 2019;25:2–14. https://doi.org/10.1093/humupd/dmy033 .
doi: 10.1093/humupd/dmy033
pubmed: 30388233
Vuong LN, Dang VQ, Ho TM, Huynh BG, Ha DT, Pham TD, et al. IVF transfer of fresh or frozen embryos in women without polycystic ovaries. N Engl J Med. 2018;378:137–47. https://doi.org/10.1056/NEJMoa1703768 .
doi: 10.1056/NEJMoa1703768
pubmed: 29320655
Wong KM, van Wely M, Mol F, Repping S, Mastenbroek S. Fresh versus frozen embryo transfers in assisted reproduction. Cochrane Database Syst Rev. 2017;3:CD011184. https://doi.org/10.1002/14651858.CD011184.pub2 .
doi: 10.1002/14651858.CD011184.pub2
pubmed: 28349510
Blockeel C, Drakopoulos P, Santos-Ribeiro S, Polyzos NP, Tournaye H. A fresh look at the freeze-all protocol: a SWOT analysis. Hum Reprod. 2016. https://doi.org/10.1093/humrep/dev339 .
doi: 10.1093/humrep/dev339
pubmed: 27927849
Coates A, Kung A, Mounts E, Hesla J, Bankowski B, Barbieri E, et al. Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial. Fertil Steril. 2017;107:723-730.e3. https://doi.org/10.1016/j.fertnstert.2016.12.022 .
doi: 10.1016/j.fertnstert.2016.12.022
pubmed: 28139240
De Ziegler D, Pirtea P, Galliano D, Cicinelli E, Meldrum D. Optimal uterine anatomy and physiology necessary for normal implantation and placentation. Fertil Steril. 2016;105:844–54. https://doi.org/10.1016/j.fertnstert.2016.02.023 .
doi: 10.1016/j.fertnstert.2016.02.023
pubmed: 26926252
Vuong LN, Pham TD, Dang VQ, Ho TM, Ho VNA, Norman RJ, et al. Live birth rates with a freeze-only strategy versus fresh embryo transfer: secondary analysis of a randomized clinical trial. Reprod Biomed Online. 2019;38:387–96. https://doi.org/10.1016/j.rbmo.2018.12.012 .
doi: 10.1016/j.rbmo.2018.12.012
pubmed: 30711459
Bourdon M, Santulli P, Maignien C, Gayet V, Pocate-Cheriet K, Marcellin L, et al. The deferred embryo transfer strategy improves cumulative pregnancy rates in endometriosis-related infertility: a retrospective matched cohort study. PLoS One. 2018;13:e0194800. https://doi.org/10.1371/journal.pone.0194800 .
doi: 10.1371/journal.pone.0194800
pubmed: 29630610
pmcid: 5890985
Ji Wu, Yang X, Huang J, Kuang Y, Wang Y. Fertility and neonatal outcomes of freeze-all vs. fresh embryo transfer in women with advanced endometriosis. Front Endocrinol (Lausanne). 2019;10:770. https://doi.org/10.3389/fendo.2019.00770 .
doi: 10.3389/fendo.2019.00770
Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C. Freeze-all can be a superior therapy to another fresh cycle in patients with prior fresh blastocyst implantation failure. Reprod Biomed Online. 2014;29:286–90. https://doi.org/10.1016/j.rbmo.2014.04.009 .
doi: 10.1016/j.rbmo.2014.04.009
pubmed: 24912413
Olausson N, Discacciati A, Nyman AI, Lundberg F, Hovatta O, Westerlund E, et al. Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilization with fresh respectively frozen-thawed embryo transfer: nationwide cohort study. J Thromb Haemost. 2020. https://doi.org/10.1111/jth.14840 .
doi: 10.1111/jth.14840
pubmed: 32289205
Papanikolaou EG, Humaidan P, Polyzos N, Kalantaridou S, Kol S, Benadiva C, et al. New algorithm for OHSS prevention. Reprod Biol Endocrinol. 2011;9:147. https://doi.org/10.1186/1477-7827-9-147 .
doi: 10.1186/1477-7827-9-147
pubmed: 22054506
pmcid: 3230134
Bourdon M, Santulli P, Gayet V, Maignien C, Marcellin L, Chapron C. Deferred frozen embryo transfer: what benefits can be expected from this strategy in patients with and without endometriosis? J Endometriosis Pelvic Pain Disorders. 2017;9:87–97. https://doi.org/10.5301/jeppd.5000281 .
doi: 10.5301/jeppd.5000281
Huang Y, Wang E-Y, Du Q-Y, Xiong Y-J, Guo X-Y, Yu Y-P, et al. Progesterone elevation on the day of human chorionic gonadotropin administration adversely affects the outcome of IVF with transferred embryos at different developmental stages. Reprod Biol Endocrinol. 2015;13:82. https://doi.org/10.1186/s12958-015-0075-3 .
doi: 10.1186/s12958-015-0075-3
pubmed: 26238449
pmcid: 4524365
Bourdon M, Santulli P, Chen Y, Patrat C, Pocate-Cheriet K, Maignien C, et al. The deferred embryo transfer strategy seems not to be a good option after repeated IVF/ICSI cycle failures. Reprod Sci. 2019;26:1210–7. https://doi.org/10.1177/1933719118811648 .
doi: 10.1177/1933719118811648
pubmed: 30458686
de Ziegler D, Gayet V, Aubriot FX, Fauque P, Streuli I, Wolf JP, et al. Use of oral contraceptives in women with endometriosis before assisted reproduction treatment improves outcomes. Fertil Steril. 2010;94:2796–9. https://doi.org/10.1016/j.fertnstert.2010.05.056 .
doi: 10.1016/j.fertnstert.2010.05.056
pubmed: 20663495
Bourdon M, Ferreux L, Maignien C, et al. Tobacco consumption is associated with slow-growing day-6 blastocysts. F S Rep. 2020;1:30–6. https://doi.org/10.1016/j.xfre.2020.04.006 .
doi: 10.1016/j.xfre.2020.04.006
pubmed: 34223209
pmcid: 8244283
Gardner DK, Schoolcraft WB, Wagley L, Schlenker T, Stevens J, Hesla J. A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization. Hum Reprod. 1998;13:3434–40. https://doi.org/10.1093/humrep/13.12.3434 .
doi: 10.1093/humrep/13.12.3434
pubmed: 9886530
Ferreux L, Bourdon M, Sallem A, Santulli P, Barraud-Lange V, Le Foll N, et al. Live birth rate following frozen-thawed blastocyst transfer is higher with blastocysts expanded on day 5 than on day 6. Hum Reprod. 2018. https://doi.org/10.1093/humrep/dey004 .
doi: 10.1093/humrep/dey004
pubmed: 29394365
Bourdon M, Santulli P, Kefelian F, Vienet-Legue L, Maignien C, Pocate-Cheriet K, et al. Prolonged estrogen (E2) treatment prior to frozen-blastocyst transfer decreases the live birth rate. Hum Reprod. 2018;33:905–13. https://doi.org/10.1093/humrep/dey041 .
doi: 10.1093/humrep/dey041
pubmed: 29529202
Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril. 2009;92:1520–4. https://doi.org/10.1016/j.fertnstert.2009.09.009 .
doi: 10.1016/j.fertnstert.2009.09.009
pubmed: 19828144
Kolte AM, Bernardi LA, Christiansen OB, Quenby S, Farquharson RG, Goddijn M, et al. Terminology for pregnancy loss prior to viability: a consensus statement from the ESHRE early pregnancy special interest group. Hum Reprod. 2015;30:495–8. https://doi.org/10.1093/humrep/deu299 .
doi: 10.1093/humrep/deu299
pubmed: 25376455
Maheshwari A, McLernon D, Bhattacharya S. Cumulative live birth rate: time for a consensus? Hum Reprod. 2015;30:2703–7. https://doi.org/10.1093/humrep/dev263 .
doi: 10.1093/humrep/dev263
pubmed: 26466912
Farquhar C, Rombauts L, Kremer JA, Lethaby A, Ayeleke RO. Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques. Cochrane Database Syst Rev. 2017;5:CD006109. https://doi.org/10.1002/14651858.CD006109.pub3 .
doi: 10.1002/14651858.CD006109.pub3
pubmed: 28540977
Wei D, Shi Y, Li J, Wang Z, Zhang L, Sun Y, et al. Effect of pretreatment with oral contraceptives and progestins on IVF outcomes in women with polycystic ovary syndrome. Hum Reprod. 2017;32:354–61. https://doi.org/10.1093/humrep/dew325 .
doi: 10.1093/humrep/dew325
pubmed: 27999118
pmcid: 5870982
Montoya-Botero P, Martinez F, Rodríguez-Purata J, Rodríguez I, Coroleu B, Polyzos NP. The effect of type of oral contraceptive pill and duration of use on fresh and cumulative live birth rates in IVF/ICSI cycles. Hum Reprod. 2020;35:826–36. https://doi.org/10.1093/humrep/dez299 .
doi: 10.1093/humrep/dez299
pubmed: 32163564
Imudia AN, Awonuga AO, Doyle JO, Kaimal AJ, Wright DL, Toth TL, et al. Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization. Fertil Steril. 2012;97:1374–9. https://doi.org/10.1016/j.fertnstert.2012.03.028 .
doi: 10.1016/j.fertnstert.2012.03.028
pubmed: 22494926
Pereira N, Elias RT, Christos PJ, Petrini AC, Hancock K, Lekovich JP, et al. Supraphysiologic estradiol is an independent predictor of low birth weight in full-term singletons born after fresh embryo transfer. Hum Reprod. 2017;32:1410–7. https://doi.org/10.1093/humrep/dex095 .
doi: 10.1093/humrep/dex095
pubmed: 28505290
pmcid: 6251696
Bourdon M, Ouazana M, Maignien C, Pocate-Cheriet K, Patrat C, Marcellin L, et al. Impact of supraphysiological estradiol serum levels on birth weight in singletons born after fresh embryo transfer. Reprod Sci. 2020. https://doi.org/10.1007/s43032-020-00174-x .
doi: 10.1007/s43032-020-00174-x
pubmed: 32072604
Maheshwari A, Pandey S, Amalraj Raja E, Shetty A, Hamilton M, Bhattacharya S. Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer? Hum Reprod Update. 2018;24:35–58. https://doi.org/10.1093/humupd/dmx031 .
doi: 10.1093/humupd/dmx031
pubmed: 29155965
Roque M, Bedoschi G, Cecchino GN, Esteves SC. Fresh versus frozen blastocyst transfer. The Lancet. 2019;394:1227–8. https://doi.org/10.1016/S0140-6736(19)31393-5 .
doi: 10.1016/S0140-6736(19)31393-5
Benaglia L, Candotti G, Papaleo E, Pagliardini L, Leonardi M, Reschini M, et al. Pregnancy outcome in women with endometriosis achieving pregnancy with IVF. Hum Reprod. 2016;31:2730–6. https://doi.org/10.1093/humrep/dew210 .
doi: 10.1093/humrep/dew210
pubmed: 27664955
Bourdon M, Santulli P, Sebbag L, Maignien C, Goffinet F, Marcellin L, et al. Risk of small for gestational age is reduced after frozen compared with fresh embryo transfer in endometriosis. Reprod Biomed Online. 2020. https://doi.org/10.1016/j.rbmo.2020.08.009 .
doi: 10.1016/j.rbmo.2020.08.009
pubmed: 33384269