Stimulation of platelet P2Y
P2Y1
aggregation
biased-agonist
chemotaxis
platelets
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
02 2024
02 2024
Historique:
revised:
13
12
2022
received:
30
05
2022
accepted:
13
01
2023
medline:
19
1
2024
pubmed:
26
1
2023
entrez:
25
1
2023
Statut:
ppublish
Résumé
Platelet function during inflammation is dependent on activation by endogenous nucleotides. Non-canonical signalling via the P2Y Platelets obtained from healthy human volunteers were incubated with ADP, Ap3A, NAD Platelet aggregation and binding to fibrinogen induced by ADP was not mimicked by NAD Platelet function (aggregation vs motility) can be differentially modulated by biased-agonist activation of P2Y This article is part of a themed issue on Platelet purinergic receptor and non-thrombotic disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.4/issuetoc.
Sections du résumé
BACKGROUND AND PURPOSE
Platelet function during inflammation is dependent on activation by endogenous nucleotides. Non-canonical signalling via the P2Y
EXPERIMENTAL APPROACH
Platelets obtained from healthy human volunteers were incubated with ADP, Ap3A, NAD
KEY RESULTS
Platelet aggregation and binding to fibrinogen induced by ADP was not mimicked by NAD
CONCLUSION AND IMPLICATIONS
Platelet function (aggregation vs motility) can be differentially modulated by biased-agonist activation of P2Y
LINKED ARTICLES
This article is part of a themed issue on Platelet purinergic receptor and non-thrombotic disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.4/issuetoc.
Substances chimiques
NAD
0U46U6E8UK
Adenosine Diphosphate
61D2G4IYVH
Fibrinogen
9001-32-5
Adenosine Diphosphate Ribose
20762-30-5
Receptors, Purinergic P2Y1
0
Receptors, Purinergic P2Y12
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
564-579Subventions
Organisme : Medical Research Council
ID : MR/T015845/1
Pays : United Kingdom
Informations de copyright
© 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
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