Ants act as olfactory bio-detectors of tumours in patient-derived xenograft mice.
Formica fusca
GC-MS
olfactory conditioning
triple-negative breast cancer
Journal
Proceedings. Biological sciences
ISSN: 1471-2954
Titre abrégé: Proc Biol Sci
Pays: England
ID NLM: 101245157
Informations de publication
Date de publication:
25 01 2023
25 01 2023
Historique:
pmc-release:
25
01
2024
entrez:
25
1
2023
pubmed:
26
1
2023
medline:
27
1
2023
Statut:
ppublish
Résumé
Early detection of cancer is critical in medical sciences, as the sooner a cancer is diagnosed, the higher are the chances of recovery. Tumour cells are characterized by specific volatile organic compounds (VOCs) that can be used as cancer biomarkers. Through olfactory associative learning, animals can be trained to detect these VOCs. Insects such as ants have a refined sense of smell, and can be easily and rapidly trained with olfactory conditioning. Using urine from patient-derived xenograft mice as stimulus, we demonstrate that individual ants can learn to discriminate the odour of healthy mice from that of tumour-bearing mice and do so after only three conditioning trials. After training, they spend approximately 20% more time in the vicinity of the learned odour than beside the other stimulus. Chemical analyses confirmed that the presence of the tumour changed the urine odour, supporting the behavioural results. Our study demonstrates that ants reliably detect tumour cues in mice urine and have the potential to act as efficient and inexpensive cancer bio-detectors.
Identifiants
pubmed: 36695032
doi: 10.1098/rspb.2022.1962
pmc: PMC9874262
doi:
Banques de données
figshare
['10.6084/m9.figshare.c.6392400']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20221962Références
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