PATTERN AND CHARACTERISTICS OF DRUSEN SUBTYPES IN CHINESE AND INDIAN POPULATIONS IN SINGAPORE.
Journal
Retina (Philadelphia, Pa.)
ISSN: 1539-2864
Titre abrégé: Retina
Pays: United States
ID NLM: 8309919
Informations de publication
Date de publication:
01 02 2023
01 02 2023
Historique:
entrez:
25
1
2023
pubmed:
26
1
2023
medline:
28
1
2023
Statut:
ppublish
Résumé
To report the pattern and characteristics of drusen subtypes in Asian populations and the association with choroidal thickness. This is the cross-sectional analysis of the population-based cohort study. Two thousand three hundred and fifty-three eyes of 1,336 Chinese and Indian participants aged older than 50 years, eyes with best-corrected visual acuity better than 20/60, and without other retinal diseases were recruited. Pachydrusen, reticular pseudodrusen, soft and hard drusen were graded on both color fundus photographs, and optical coherence tomography imaging with automated segmentation yielding and measurements of choroidal thickness. Nine hundred and fifty-five Chinese and 381 Indians were included in the final analysis. The pattern of pachydrusen, soft drusen, hard drusen, and reticular pseudodrusen was 14.0%, 3.7%, 12.5%, and 0.2%, respectively. Mean choroidal thickness was the thickest in eyes with pachydrusen (298.3 μm; 95% confidence interval: 290.5-306.1), then eyes with hard (298.1 μm; 95% confidence interval: 290.6-305.5) and soft drusen (293.7 μm; 95% confidence interval: 281.9-305.4) and thinnest in eyes without drusen (284.6 μm; 95% confidence interval: 280.5-288.7). Systemic associations of the various drusen subtypes also differed. Patterns, characterization and choroidal thickness of drusen subtypes, and their associations provide insights into the Asian phenotypic spectrum of age-related macular degeneration and the underlying pathogenesis.
Identifiants
pubmed: 36695800
doi: 10.1097/IAE.0000000000003651
pii: 00006982-202302000-00016
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
303-312Références
Kawasaki R, Yasuda M, Song SJ, et al. The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis. Ophthalmology 2010;117:921–927.
Lim LS, Mitchell P, Seddon JM, et al. Age-related macular degeneration. Lancet 2012;379:1728–1738.
Wong WL, Su X, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health 2014;2:e106–e116.
Cheung CMG, Gan A, Yanagi Y, et al. Association between choroidal thickness and drusen subtypes in age-related macular degeneration. Ophthalmol Retina 2018;2:1196–1205.
Sasaki M, Kawasaki R, Uchida A, et al. Early signs of exudative age-related macular degeneration in Asians. Optom Vis Sci 2014;91:849–853.
Manjunath V, Goren J, Fujimoto JG, Duker JS. Analysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography. Am J Ophthalmol 2011;152:663–668.
Kim SW, Oh J, Kwon SS, et al. Comparison of choroidal thickness among patients with healthy eyes, early age-related maculopathy, neovascular age-related macular degeneration, central serous chorioretinopathy, and polypoidal choroidal vasculopathy. Retina 2011;31:1904–1911.
Chung SE, Kang SW, Lee JH, Kim YT. Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration. Ophthalmology 2011;118:840–845.
Folgar FA, Yuan EL, Sevilla MB, et al. Drusen volume and retinal pigment epithelium abnormal thinning volume predict 2-year progression of age-related macular degeneration. Ophthalmology 2016;123:39–50.e1.
Wang JJ, Foran S, Smith W, Mitchell P. Risk of age-related macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort. Arch Ophthalmol 2003;121:658–663.
Spaide RF. Disease expression in nonexudative age-related macular degeneration varies with choroidal thickness. Retina 2018;38:708–716.
Majithia S, Tham YC, Chee ML, et al. Singapore Chinese Eye Study: key findings from baseline examination and the rationale, methodology of the 6-year follow-up series. Br J Ophthalmol 2020;104:610–615.
Sabanayagam C, Yip W, Gupta P, et al. Singapore Indian Eye Study-2: methodology and impact of migration on systemic and eye outcomes. Clin Exp Ophthalmol 2017;45:779–789.
Rosman M, Zheng Y, Wong W, et al. Singapore Malay Eye Study: rationale and methodology of 6-year follow-up study (SiMES-2). Clin Exp Ophthalmol 2012;40:557–568.
Lavanya R, Jeganathan VSE, Zheng Y, et al. Methodology of the Singapore Indian Chinese cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians. Ophthalmic Epidemiol 2009;16:325–336.
Song Y, Tham Y-C, Chong C, et al. Patterns and determinants of choroidal thickness in a multiethnic asian population: the Singapore epidemiology of eye diseases study. Ophthalmol Retina 2021;5:458–467.
Age-Related Eye Disease Study Research Group. The age-related eye disease study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the age-related eye disease study report number 6. Am J Ophthalmol 2001;132:668–681.
Boddu S, Lee MD, Marsiglia M, et al. Risk factors associated with reticular pseudodrusen versus large soft drusen. Am J Ophthalmol 2014;157:985–993.e2.
Vitale S, Clemons TE, Agrón E, et al. Evaluating the validity of the age-related eye disease study grading scale for age-related macular degeneration: AREDS2 report 10. JAMA Ophthalmol 2016;134:1041–1047.
Kawasaki R, Wang JJ, Aung T, et al. Prevalence of age-related macular degeneration in a Malay population: the Singapore Malay eye study. Ophthalmology 2008;115:1735–1741.
Sasaki M, Ito Y, Yamasaki T, et al. Association of choroidal thickness with intermediate age-related macular degeneration in a Japanese population. Ophthalmol Retina 2021;5:528–535.
Zhang X, Sivaprasad S. Drusen and pachydrusen: the definition, pathogenesis, and clinical significance. Eye (Lond) 2021;35:121–133.
Munch IC, Ek J, Kessel L, et al. Small, hard macular drusen and peripheral drusen: associations with AMD genotypes in the Inter99 eye study. Invest Opthalmology Vis Sci 2010;51:2317–2321.
Matsumoto H, Hoshino J, Mukai R, et al. Vortex vein anastomosis at the watershed in pachychoroid spectrum diseases. Ophthalmol Retina 2020;4:938–945.
Yanagi Y. Pachychoroid disease: a new perspective on exudative maculopathy. Jpn J Ophthalmol 2020;64:323–337.
Warrow DJ, Hoang QV, Freund KB. Retina 2013;33:1659–1672.
Rudolf M, Clark ME, Chimento MF, et al. Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathy. Invest Opthalmology Vis Sci 2008;49:1200–1209.