Malian children infected with Plasmodium ovale and Plasmodium falciparum display very similar gene expression profiles.
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
08
09
2022
accepted:
16
01
2023
revised:
06
02
2023
pubmed:
26
1
2023
medline:
9
2
2023
entrez:
25
1
2023
Statut:
epublish
Résumé
Plasmodium parasites caused 241 million cases of malaria and over 600,000 deaths in 2020. Both P. falciparum and P. ovale are endemic to Mali and cause clinical malaria, with P. falciparum infections typically being more severe. Here, we sequenced RNA from nine pediatric blood samples collected during infections with either P. falciparum or P. ovale, and characterized the host and parasite gene expression profiles. We found that human gene expression varies more between individuals than according to the parasite species causing the infection, while parasite gene expression profiles cluster by species. Additionally, we characterized DNA polymorphisms of the parasites directly from the RNA-seq reads and found comparable levels of genetic diversity in both species, despite dramatic differences in prevalence. Our results provide unique insights into host-pathogen interactions during malaria infections and their variations according to the infecting Plasmodium species, which will be critical to develop better elimination strategies against all human Plasmodium parasites.
Identifiants
pubmed: 36696438
doi: 10.1371/journal.pntd.0010802
pii: PNTD-D-22-01170
pmc: PMC9901758
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0010802Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007524
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI065683
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130750
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI099628
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW001589
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI095190
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146377
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI146853
Pays : United States
Informations de copyright
Copyright: © 2023 Tebben et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
None
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