Insulin resistance and lipid levels in the middle-aged offspring of parents with severe mental illness.


Journal

Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207

Informations de publication

Date de publication:
02 2023
Historique:
received: 04 07 2022
revised: 28 11 2022
accepted: 07 01 2023
pubmed: 26 1 2023
medline: 3 3 2023
entrez: 25 1 2023
Statut: ppublish

Résumé

Type 2 diabetes and dyslipidemias co-occur frequently with severe mental illnesses (SMI). However, less is known about serum insulin and lipid levels and prevalence of Insulin Resistance (IR) in offspring with familial risk for SMI. The Northern Finland Birth Cohort 1966 consists of 12,068 mothers, 11,068 fathers, and 12,231 children from the two northernmost provinces in Finland. At age 46 they participated in clinical examination including measurements of glucose, lipids, and IR and answered a questionnaire including information about their nutrition and physical activity. The information on parental SMI was obtained from the Hospital Discharge Register. Parents with SMI were those who had been treated in hospital for any psychiatric disorder during 1969-1982 (ICD-8 codes 290-315). The final study group included 334 (7.3 %) offspring who had a parent with SMI and 4249 (92.7 %) offspring in the comparison group. We did not find increased risk for disturbances in lipid levels, insulin levels, or IR levels between the study group (offspring of either parent with SMI) compared with the comparison group. All offspring, especially female offspring of either parent with SMI, had an increased risk for higher glucose levels and waist circumference. The results remained the same after excluding offspring with SMI. Our findings suggest that offspring of parents with SMI, especially female offspring, have partly increased risk for disturbances in cardiometabolic risk factors. Disturbances in glucose metabolism may have an effect via familial risk of severe mental illness.

Sections du résumé

BACKGROUND
Type 2 diabetes and dyslipidemias co-occur frequently with severe mental illnesses (SMI). However, less is known about serum insulin and lipid levels and prevalence of Insulin Resistance (IR) in offspring with familial risk for SMI.
METHOD
The Northern Finland Birth Cohort 1966 consists of 12,068 mothers, 11,068 fathers, and 12,231 children from the two northernmost provinces in Finland. At age 46 they participated in clinical examination including measurements of glucose, lipids, and IR and answered a questionnaire including information about their nutrition and physical activity. The information on parental SMI was obtained from the Hospital Discharge Register. Parents with SMI were those who had been treated in hospital for any psychiatric disorder during 1969-1982 (ICD-8 codes 290-315). The final study group included 334 (7.3 %) offspring who had a parent with SMI and 4249 (92.7 %) offspring in the comparison group.
RESULTS
We did not find increased risk for disturbances in lipid levels, insulin levels, or IR levels between the study group (offspring of either parent with SMI) compared with the comparison group. All offspring, especially female offspring of either parent with SMI, had an increased risk for higher glucose levels and waist circumference. The results remained the same after excluding offspring with SMI.
CONCLUSION
Our findings suggest that offspring of parents with SMI, especially female offspring, have partly increased risk for disturbances in cardiometabolic risk factors. Disturbances in glucose metabolism may have an effect via familial risk of severe mental illness.

Identifiants

pubmed: 36696701
pii: S0920-9964(23)00025-7
doi: 10.1016/j.schres.2023.01.013
pii:
doi:

Substances chimiques

Glucose IY9XDZ35W2
Lipids 0
Insulins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

271-278

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest None.

Auteurs

Maria Protsenko (M)

Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland. Electronic address: maria.protsenko@oulu.fi.

Martta Kerkelä (M)

Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland.

Jouko Miettunen (J)

Research Unit of Population Health, University of Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland.

Juha Auvinen (J)

Research Unit of Population Health, University of Oulu, Finland.

Marjo-Riitta Järvelin (MR)

Research Unit of Population Health, University of Oulu, Finland.

Peter B Jones (PB)

Department of Psychiatry, University of Cambridge, UK.

Mika Gissler (M)

THL, Department of Knowledge Brokers, Finnish Institute for Health and Welfare, Helsinki, Finland; University of Turku, Research Centre for Child Psychiatry, Turku, Finland; Karolinska Institute, Department of Molecular Medicine and Surgery, Stockholm, Sweden.

Juha Veijola (J)

Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland; Department of Psychiatry, University Hospital of Oulu, Finland.

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Classifications MeSH