Targeting undruggable carbohydrate recognition sites through focused fragment library design.
Journal
Communications chemistry
ISSN: 2399-3669
Titre abrégé: Commun Chem
Pays: England
ID NLM: 101725670
Informations de publication
Date de publication:
20 May 2022
20 May 2022
Historique:
received:
05
01
2022
accepted:
29
04
2022
entrez:
25
1
2023
pubmed:
26
1
2023
medline:
26
1
2023
Statut:
epublish
Résumé
Carbohydrate-protein interactions are key for cell-cell and host-pathogen recognition and thus, emerged as viable therapeutic targets. However, their hydrophilic nature poses major limitations to the conventional development of drug-like inhibitors. To address this shortcoming, four fragment libraries were screened to identify metal-binding pharmacophores (MBPs) as novel scaffolds for inhibition of Ca
Identifiants
pubmed: 36697615
doi: 10.1038/s42004-022-00679-3
pii: 10.1038/s42004-022-00679-3
pmc: PMC9814205
doi:
Types de publication
Journal Article
Langues
eng
Pagination
64Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : RA1944/7-1
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-17-CE11-0048
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-17-EURE-0003
Informations de copyright
© 2022. The Author(s).
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