Advanced preparation of fragment libraries enabled by oligonucleotide-modified 2',3'-dideoxynucleotides.
Journal
Communications chemistry
ISSN: 2399-3669
Titre abrégé: Commun Chem
Pays: England
ID NLM: 101725670
Informations de publication
Date de publication:
16 Mar 2022
16 Mar 2022
Historique:
received:
23
09
2021
accepted:
07
02
2022
entrez:
25
1
2023
pubmed:
26
1
2023
medline:
26
1
2023
Statut:
epublish
Résumé
The ever-growing demand for inexpensive, rapid, and accurate exploration of genomes calls for refinement of existing sequencing techniques. The development of next-generation sequencing (NGS) was a revolutionary milestone in genome analysis. While modified nucleotides already were inherent tools in sequencing and imaging, further modification of nucleotides enabled the expansion into even more diverse applications. Herein we describe the design and synthesis of oligonucleotide-tethered 2',3'-dideoxynucleotide (dd
Identifiants
pubmed: 36697673
doi: 10.1038/s42004-022-00649-9
pii: 10.1038/s42004-022-00649-9
pmc: PMC9814608
doi:
Types de publication
Journal Article
Langues
eng
Pagination
34Informations de copyright
© 2022. The Author(s).
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