Antibiofilm Activity and Synergistic Effects of Thymol-Loaded Poly (Lactic-Co-Glycolic Acid) Nanoparticles with Amikacin against Four
Journal
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
ISSN: 1712-9532
Titre abrégé: Can J Infect Dis Med Microbiol
Pays: Egypt
ID NLM: 101226876
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
06
2022
revised:
02
12
2022
accepted:
26
12
2022
entrez:
26
1
2023
pubmed:
27
1
2023
medline:
27
1
2023
Statut:
epublish
Résumé
Salmonella species are frequently linked to biofilm-associated infections. Biofilm formation intensively reduces the efficacy of antibiotics and the host immune system. Therefore, new therapeutic strategies are needed. Thymol, the main monoterpene phenol found in The antibacterial activity of TH-NPs was evaluated using the broth microdilution method. Biofilm formation and antibiofilm assays were performed by the miniaturized microtiter plate method. Interaction studies between TH-NPs and amikacin against biofilm were determined using the checkerboard method. TH-NPs exhibited antibacterial activity against planktonic cells of This study suggests that the combination of TH-NPs with amikacin can be an alternative to overcome biofilm-associated
Sections du résumé
Background
UNASSIGNED
Salmonella species are frequently linked to biofilm-associated infections. Biofilm formation intensively reduces the efficacy of antibiotics and the host immune system. Therefore, new therapeutic strategies are needed. Thymol, the main monoterpene phenol found in
Methods
UNASSIGNED
The antibacterial activity of TH-NPs was evaluated using the broth microdilution method. Biofilm formation and antibiofilm assays were performed by the miniaturized microtiter plate method. Interaction studies between TH-NPs and amikacin against biofilm were determined using the checkerboard method.
Results
UNASSIGNED
TH-NPs exhibited antibacterial activity against planktonic cells of
Conclusion
UNASSIGNED
This study suggests that the combination of TH-NPs with amikacin can be an alternative to overcome biofilm-associated
Identifiants
pubmed: 36698730
doi: 10.1155/2023/7274309
pmc: PMC9870694
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7274309Informations de copyright
Copyright © 2023 Christian Ramsès Kuaté Tokam et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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