Variability in oxidative stress-related genes (

antioxidant enzymes migraine genetics primary headaches redox homeostasis single nucleotide polymorphisms (SNPs)

Journal

Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899

Informations de publication

Date de publication:
2022
Historique:
received: 07 10 2022
accepted: 13 12 2022
entrez: 26 1 2023
pubmed: 27 1 2023
medline: 27 1 2023
Statut: epublish

Résumé

Migraine is a complex disorder with genetic and environmental inputs. Cumulative evidence implicates oxidative stress (OS) in migraine pathophysiology while genetic variability may influence an individuals' oxidative/antioxidant capacity. Aim of the current study was to investigate the impact of eight common OS-related genetic variants [rs4880 ( Genomic DNA samples from 221 unrelated migraineurs and 265 headache-free controls were genotyped for the selected genetic variants using real-time PCR (melting curve analysis). Although allelic and genotypic frequency distribution analysis did not support an association between migraine susceptibility and the examined variants in the overall population, subgroup analysis indicated significant correlation between Hence, the current findings possibly indicate an association of OS-related genetic variants with migraine susceptibility and clinical features, further supporting the involvement of OS and genetic susceptibility in migraine.

Identifiants

DOI: 10.3389/fneur.2022.1054333 PMID: 36698892 PMC: PMC9868718
pubmed: 36698892
doi: 10.3389/fneur.2022.1054333
pmc: PMC9868718
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1054333

Informations de copyright

Copyright © 2023 Papasavva, Vikelis, Siokas, Katsarou, Dermitzakis, Raptis, Kalliantasi, Dardiotis and Drakoulis.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Maria Papasavva (M)

Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

Michail Vikelis (M)

Headache Clinic, Mediterraneo Hospital, Glyfada, Greece.

Vasileios Siokas (V)

Laboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Larissa, Greece.
Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

Martha-Spyridoula Katsarou (MS)

Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

Emmanouil V Dermitzakis (EV)

Euromedica General Clinic, Thessaloniki, Greece.

Athanasios Raptis (A)

Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

Aikaterini Kalliantasi (A)

Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

Efthimios Dardiotis (E)

Laboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Larissa, Greece.
Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

Nikolaos Drakoulis (N)

Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

Classifications MeSH