Mechanosignals in abdominal aortic aneurysms.
abdominal aortic aneurysm
mechanical stress
mechanosignals
mechanotransduction
shear stress
vascular pathology
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
08
2022
accepted:
29
11
2022
entrez:
26
1
2023
pubmed:
27
1
2023
medline:
27
1
2023
Statut:
epublish
Résumé
Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA). These mechanical cues collectively trigger signaling cascades relying on mechanosensory cellular hubs that regulate vascular remodeling programs leading to the exaggerated degradation of the extracellular matrix (ECM), culminating in lethal aortic rupture. In this review, we provide an update and summarize the current understanding of the mechanotransduction networks in different cell types during AAA development. We focus on different mechanosensors and stressors that accumulate in the AAA sac and the mechanotransduction cascades that contribute to inflammation, oxidative stress, remodeling, and ECM degradation. We provide perspectives on manipulating this mechano-machinery as a new direction for future research in AAA.
Identifiants
pubmed: 36698932
doi: 10.3389/fcvm.2022.1021934
pmc: PMC9868277
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1021934Informations de copyright
Copyright © 2023 Lowis, Ramara Winaya, Kumari, Rivera, Vlahos, Hermantara, Pratama and Ramkhelawon.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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