Cerebrovascular impedance estimation with near-infrared and diffuse correlation spectroscopy.
cerebral autoregulation
cerebrovascular impedance
cerebrovascular resistance
diffuse correlation spectroscopy
near infrared spectroscopy
pulsatile hemodynamics
Journal
Neurophotonics
ISSN: 2329-423X
Titre abrégé: Neurophotonics
Pays: United States
ID NLM: 101632875
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
10
05
2022
accepted:
29
12
2022
entrez:
26
1
2023
pubmed:
27
1
2023
medline:
27
1
2023
Statut:
ppublish
Résumé
Cerebrovascular impedance (CVI) is related to cerebral autoregulation (CA), which is the mechanism of the brain to maintain near-constant cerebral blood flow (CBF) despite changes in cerebral perfusion pressure (CPP). Changes in blood vessel impedance enable the stabilization of blood flow. Due to the interplay between CVI and CA, assessment of CVI may enable quantification of CA and may serve as a biomarker for cerebral health. We developed a method to quantify CVI based on a combination of diffuse correlation spectroscopy (DCS) and continuous wave (CW) near-infrared spectroscopy (NIRS). Data on healthy human volunteers were used to validate the method. A combined high-speed DCS-NIRS system was developed, allowing for simultaneous, noninvasive blood flow, and volume measurements in the same tissue compartment. Blood volume was used as a surrogate measurement for blood pressure and CVI was calculated as the spectral ratio of blood volume and blood flow changes. This technique was validated on six healthy human volunteers undergoing postural changes to elicit CVI changes. Averaged across the six subjects, a decrease in CVI was found for a head of bed (HOB) tilting of We developed a combined DCS-NIRS system, which measures CBF and volume changes, which we demonstrate can be used to measure CVI. Using CVI as a metric of CA may be beneficial for assessing cerebral health, especially in patients where CPP is altered.
Identifiants
pubmed: 36699625
doi: 10.1117/1.NPh.10.1.015002
pii: 22036GRR
pmc: PMC9868286
doi:
Types de publication
Journal Article
Langues
eng
Pagination
015002Informations de copyright
© 2023 The Authors.
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