The molecular biology of peritoneal metastatic disease.
gastrointestinal cancer
metastasis
peritoneum
tumor biology
tumor microenvironment
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
08 03 2023
08 03 2023
Historique:
revised:
07
12
2022
received:
14
10
2022
accepted:
09
12
2022
pubmed:
27
1
2023
medline:
11
3
2023
entrez:
26
1
2023
Statut:
ppublish
Résumé
Peritoneal metastases are a common form of tumor cell dissemination in gastrointestinal malignancies. Peritoneal metastatic disease (PMD) is associated with severe morbidity and resistance to currently employed therapies. Given the distinct route of dissemination compared with distant organ metastases, and the unique microenvironment of the peritoneal cavity, specific tumor cell characteristics are needed for the development of PMD. In this review, we provide an overview of the known histopathological, genomic, and transcriptomic features of PMD. We find that cancers representing the mesenchymal subtype are strongly associated with PMD in various malignancies. Furthermore, we discuss the peritoneal niche in which the metastatic cancer cells reside, including the critical role of the peritoneal immune system. Altogether, we show that PMD should be regarded as a distinct disease entity, that requires tailored treatment strategies.
Identifiants
pubmed: 36700339
doi: 10.15252/emmm.202215914
pmc: PMC9994485
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15914Informations de copyright
© 2023 The Authors. Published under the terms of the CC BY 4.0 license.
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