Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study.
Alzheimer disease
Vascular
cerebral small vessel diseases
dementia
leukoencephalopathies
Journal
Psychiatry and clinical neurosciences
ISSN: 1440-1819
Titre abrégé: Psychiatry Clin Neurosci
Pays: Australia
ID NLM: 9513551
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
revised:
05
12
2022
received:
05
10
2022
accepted:
19
01
2023
medline:
2
6
2023
pubmed:
27
1
2023
entrez:
26
1
2023
Statut:
ppublish
Résumé
To investigate the association of white matter lesions volume (WMLV) levels with dementia risk and the association between dementia risk and the combined measures of WMLV and either total brain atrophy or dementia-related gray matter atrophy in a general older population. One thousand one hundred fifty-eight Japanese dementia-free community-residents aged ≥65 years who underwent brain magnetic resonance imaging were followed for 5.0 years. WMLV were segmented using the Lesion Segmentation Toolbox. Total brain volume (TBV) and regional gray matter volume were estimated by voxel-based morphometry. The WMLV-to-intracranial brain volume ratio (WMLV/ICV) was calculated, and its association with dementia risk was estimated using Cox proportional hazard models. Total brain atrophy, defined as the TBV-to-ICV ratio (TBV/ICV), and dementia-related regional brain atrophy defined based on our previous report were calculated. The association between dementia risk and the combined measures of WMLV/ICV and either total brain atrophy or the number of atrophied regions was also tested. During the follow-up, 113 participants developed dementia. The risks of dementia increased significantly with higher WMLV/ICV levels. In addition, dementia risk increased additively both in participants with higher WMLV/ICV levels and lower TBV/ICV levels and in those with higher WMLV/ICV levels and a higher number of dementia-related brain regional atrophy. The risk of dementia increased significantly with higher WMLV/ICV levels. An additive increment in dementia risk was observed with higher WMLV/ICV levels and lower TBV/ICV levels or a higher number of dementia-related brain regional atrophy, suggesting the importance of prevention or control of cardiovascular risk factors.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
330-337Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP22dk0207053
Organisme : the Health and Labour Sciences Research Grants of the Ministry of Health, Labour and Welfare of Japan
ID : JPMH20FA1002
Organisme : the Ministry of Education, Culture, Sports, Science and Technology of Japan (JSPS KAKENHI)
ID : JP19K07890
Organisme : the Ministry of Education, Culture, Sports, Science and Technology of Japan (JSPS KAKENHI)
ID : JP20K10503
Organisme : the Ministry of Education, Culture, Sports, Science and Technology of Japan (JSPS KAKENHI)
ID : JP20K11020
Organisme : the Ministry of Education, Culture, Sports, Science and Technology of Japan (JSPS KAKENHI)
ID : JP21H03200
Organisme : the Ministry of Education, Culture, Sports, Science and Technology of Japan (JSPS KAKENHI)
ID : JP21K07522
Organisme : the Ministry of Education, Culture, Sports, Science and Technology of Japan (JSPS KAKENHI)
ID : JP21K10448
Organisme : the Ministry of Education, Culture, Sports, Science and Technology of Japan (JSPS KAKENHI)
ID : JP21K11725
Organisme : the Ministry of Education, Culture, Sports, Science and Technology of Japan (JSPS KAKENHI)
ID : JP22K07421
Organisme : the Ministry of Education, Culture, Sports, Science and Technology of Japan (JSPS KAKENHI)
ID : JP22K17396
Informations de copyright
© 2023 The Authors. Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.
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