Accuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study.
Journal
Revista da Sociedade Brasileira de Medicina Tropical
ISSN: 1678-9849
Titre abrégé: Rev Soc Bras Med Trop
Pays: Brazil
ID NLM: 7507456
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
04
2022
accepted:
13
10
2022
entrez:
26
1
2023
pubmed:
27
1
2023
medline:
28
1
2023
Statut:
epublish
Résumé
The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated the performance of the URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently available in Brazil. Residents from eight sites with different prevalence estimates provided one urine sample for POC-ECO and one stool sample for Kato-Katz (KK) and Helmintex® (HTX) testing as an egg-detecting reference for infection status. None of the study sites had significantly higher POC-ECO accuracy than KK. POC-ECO is not currently recommended in Brazilian schistosomiasis elimination programs.
Sections du résumé
BACKGROUND
BACKGROUND
The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated the performance of the URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently available in Brazil.
METHODS
METHODS
Residents from eight sites with different prevalence estimates provided one urine sample for POC-ECO and one stool sample for Kato-Katz (KK) and Helmintex® (HTX) testing as an egg-detecting reference for infection status.
RESULTS
RESULTS
None of the study sites had significantly higher POC-ECO accuracy than KK.
CONCLUSIONS
CONCLUSIONS
POC-ECO is not currently recommended in Brazilian schistosomiasis elimination programs.
Identifiants
pubmed: 36700600
pii: S0037-86822023000100600
doi: 10.1590/0037-8682-0238-2022
pmc: PMC9870275
pii:
doi:
Substances chimiques
Antigens, Helminth
0
Types de publication
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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