Comparison of Three β-Glucan Tests for the Diagnosis of Invasive Candidiasis in Intensive Care Units.


Journal

Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564

Informations de publication

Date de publication:
22 02 2023
Historique:
pubmed: 27 1 2023
medline: 3 3 2023
entrez: 26 1 2023
Statut: ppublish

Résumé

The (1→3)-β-d-glucan (BDG) is a marker of invasive fungal infection that can be detected in serum by different commercial kits. In this study, we compared the performance of the Fungitell assay (FA), the Fungitell STAT assay (STAT), and the Wako β-glucan test (WA) for the diagnosis of invasive candidiasis (IC) in the intensive care unit (ICU). Patients for whom at least one BDG testing was required for a clinical suspicion of IC were retrospectively enrolled. A total of 85 serum samples from 56 patients were tested by the three BDG tests. The rate of IC was 23% (13/56) with a predominance of noncandidemic (intra-abdominal) IC. STAT and WA results exhibited overall good correlation with those obtained by FA (Spearman's coefficient

Identifiants

pubmed: 36700626
doi: 10.1128/jcm.01691-22
pmc: PMC9945570
doi:

Substances chimiques

beta-Glucans 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0169122

Auteurs

A Kritikos (A)

Institute of Microbiology, Department of Laboratories, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

G Caruana (G)

Institute of Microbiology, Department of Laboratories, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

J Poissy (J)

University of Lille, INSERM U1285, CHU Lille, Pôle de Médecine Intensive/Réanimation, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, Lille, France.

A Mamin (A)

Institute of Microbiology, Department of Laboratories, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

D Bachmann (D)

Institute of Microbiology, Department of Laboratories, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

J L Pagani (JL)

Service of Intensive Care Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

A T Coste (AT)

Institute of Microbiology, Department of Laboratories, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

F Lamoth (F)

Institute of Microbiology, Department of Laboratories, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

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Classifications MeSH