Shedding Light on PARP Inhibitor Response through Functional Imaging.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
14 04 2023
14 04 2023
Historique:
received:
19
12
2022
revised:
06
01
2023
accepted:
19
01
2023
medline:
17
4
2023
pubmed:
27
1
2023
entrez:
26
1
2023
Statut:
ppublish
Résumé
Functional PET imaging using a PARP inhibitor (PARPi) analog may serve as an early, dynamic biomarker of response to PARPi therapy in high-grade serous ovarian cancer. Clinically, this could help to rapidly identify PARPi nonresponders, thereby maximizing efficacy and avoiding toxicities of futile treatments. See related article by Pantel et al., p. 1515.
Identifiants
pubmed: 36700799
pii: 716223
doi: 10.1158/1078-0432.CCR-22-3711
pmc: PMC10106371
mid: NIHMS1867162
doi:
Substances chimiques
Poly(ADP-ribose) Polymerase Inhibitors
0
Antineoplastic Agents
0
Biomarkers
0
Types de publication
Editorial
Research Support, N.I.H., Extramural
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
1384-1386Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentOn
Informations de copyright
©2023 American Association for Cancer Research.
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