An extended interval between vaccination and infection enhances hybrid immunity against SARS-CoV-2 variants.
Adaptive immunity
COVID-19
Immunoglobulins
Vaccines
Journal
JCI insight
ISSN: 2379-3708
Titre abrégé: JCI Insight
Pays: United States
ID NLM: 101676073
Informations de publication
Date de publication:
08 03 2023
08 03 2023
Historique:
received:
08
09
2022
accepted:
23
01
2023
pubmed:
27
1
2023
medline:
10
3
2023
entrez:
26
1
2023
Statut:
epublish
Résumé
As the COVID-19 pandemic continues, long-term immunity against SARS-CoV-2 will be important globally. Official weekly cases have not dropped below 2 million since September of 2020, and continued emergence of novel variants has created a moving target for our immune systems and public health alike. The temporal aspects of COVID-19 immunity, particularly from repeated vaccination and infection, are less well understood than short-term vaccine efficacy. In this study, we explored the effect of combined vaccination and infection, also known as hybrid immunity, and the timing thereof on the quality and quantity of antibodies elicited in a cohort of 96 health care workers. We found robust neutralizing antibody responses among those with hybrid immunity; these hybrid immune responses neutralized all variants, including BA.2. Neutralizing titers were significantly improved for those with longer vaccine-infection intervals of up to 400 days compared with those with shorter intervals. These results indicate that anti-SARS-CoV-2 antibody responses undergo continual maturation following primary exposure by either vaccination or infection for at least 400 days after last antigen exposure. We show that neutralizing antibody responses improved upon secondary boosting, with greater potency seen after extended intervals. Our findings may also extend to booster vaccine doses, a critical consideration in future vaccine campaign strategies.
Identifiants
pubmed: 36701200
pii: 165265
doi: 10.1172/jci.insight.165265
pmc: PMC10077480
doi:
pii:
Substances chimiques
Antibodies, Neutralizing
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL083808
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI141549
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145835
Pays : United States
Commentaires et corrections
Type : UpdateOf
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