Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma.
Journal
NPJ genomic medicine
ISSN: 2056-7944
Titre abrégé: NPJ Genom Med
Pays: England
ID NLM: 101685193
Informations de publication
Date de publication:
26 Jan 2023
26 Jan 2023
Historique:
received:
29
03
2022
accepted:
18
11
2022
entrez:
26
1
2023
pubmed:
27
1
2023
medline:
27
1
2023
Statut:
epublish
Résumé
Despite advancements in understanding the pathophysiology of Multiple Myeloma (MM), the cause of rapid progressing disease in a subset of patients is still unclear. MM's progression is facilitated by complex interactions with the surrounding bone marrow (BM) cells, forming a microenvironment that supports tumor growth and drug resistance. Understanding the immune microenvironment is key to identifying factors that promote rapid progression of MM. To accomplish this, we performed a multi-center single-cell RNA sequencing (scRNA-seq) study on 102,207 cells from 48 CD138
Identifiants
pubmed: 36702834
doi: 10.1038/s41525-022-00340-x
pii: 10.1038/s41525-022-00340-x
pmc: PMC9879959
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3Subventions
Organisme : NCI NIH HHS
ID : P30 CA196521
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA224319
Pays : United States
Informations de copyright
© 2023. The Author(s).
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