Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry.

Humans Female Breast Neoplasms / genetics Genetic Predisposition to Disease Black People Genetic Testing Genome-Wide Association Study / methods Polymorphism, Single Nucleotide Formins / genetics
Breast cancer susceptibility Diverse ancestry Gene regulation Genome-wide association study Rare variants

Journal

Genome medicine
ISSN: 1756-994X
Titre abrégé: Genome Med
Pays: England
ID NLM: 101475844

Informations de publication

Date de publication:
26 01 2023
Historique:
received: 05 05 2022
accepted: 16 12 2022
entrez: 26 1 2023
pubmed: 27 1 2023
medline: 31 1 2023
Statut: epublish

Résumé

Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes. We evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry. In European ancestry samples, 14 genes were significantly associated (q < 0.05) with BC. Of those, two genes, FMNL3 (P = 6.11 × 10 Using extended gene-based aggregation tests including coding and regulatory variation, we report identification of plausible target genes for previously identified single-marker associations with BC as well as the discovery of novel genes implicated in BC development. Including multi ancestral cohorts in this study enabled the identification of otherwise missed disease associations as ESR1 (P = 1.31 × 10

Sections du résumé

BACKGROUND
Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.
METHODS
We evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry.
RESULTS
In European ancestry samples, 14 genes were significantly associated (q < 0.05) with BC. Of those, two genes, FMNL3 (P = 6.11 × 10
CONCLUSIONS
Using extended gene-based aggregation tests including coding and regulatory variation, we report identification of plausible target genes for previously identified single-marker associations with BC as well as the discovery of novel genes implicated in BC development. Including multi ancestral cohorts in this study enabled the identification of otherwise missed disease associations as ESR1 (P = 1.31 × 10

Identifiants

DOI: 10.1186/s13073-022-01152-5 PMID: 36703164 PMC: PMC9878779
pubmed: 36703164
doi: 10.1186/s13073-022-01152-5
pii: 10.1186/s13073-022-01152-5
pmc: PMC9878779
doi:

Substances chimiques

FMNL3 protein, human 0
Formins 0

Types de publication

Meta-Analysis Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Research Support, N.I.H., Intramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

7

Subventions

Organisme : NCI NIH HHS
ID : UM1 CA164917
Pays : United States
Organisme : Cancer Research UK
ID : C12292/A11174
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P50 CA116201
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Cancer Research UK
ID : C1287/A10118
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : Z01 ES044005
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 ES049033
Pays : United States
Organisme : Cancer Research UK
ID : C1275/A19187
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C8221/A19170
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA148667
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201800032I
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148112
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA058223
Pays : United States
Organisme : Cancer Research UK
ID : C1287/A10710
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA120120
Pays : United States
Organisme : Cancer Research UK
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Pays : United Kingdom
Organisme : NCI NIH HHS
ID : HHSN261201800015I
Pays : United States
Organisme : Cancer Research UK
ID : 29186
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : HHSN261201800009I
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA176726
Pays : United States
Organisme : Cancer Research UK
ID : C1275/C22524
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : Z01 CP010119
Pays : United States
Organisme : Cancer Research UK
ID : C1287/A16563
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00004/01
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Organisme : Cancer Research UK
ID : C5047/A10692
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA023100
Pays : United States
Organisme : Cancer Research UK
ID : C490/A16561
Pays : United Kingdom
Organisme : Medical Research Council
ID : 1000143
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C490/A10124
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA192393
Pays : United States
Organisme : Cancer Research UK
ID : C5047/A8384
Pays : United Kingdom
Organisme : NCCDPHP CDC HHS
ID : NU58DP006344
Pays : United States
Organisme : Cancer Research UK
ID : C570/A16491
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U19 CA148065
Pays : United States
Organisme : Cancer Research UK
ID : C1275/A11699
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : Medical Research Council
ID : MR/M012190/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5047/A15007
Pays : United Kingdom
Organisme : Department of Health
ID : PGFAR 0707-10031
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : Z01 ES049030
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA125183
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA176785
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW009112
Pays : United States
Organisme : Department of Health
ID : IS-BRC-1215-20007
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : K24 CA169004
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA156733
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA253187
Pays : United States
Organisme : Cancer Research UK
ID : 10118
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA077398
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA100374
Pays : United States
Organisme : Cancer Research UK
ID : C1275/A15956
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U01 CA164920
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA176726
Pays : United States
Organisme : Cancer Research UK
ID : C1281/A12014
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U01 CA199277
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA164920
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA179715
Pays : United States
Organisme : Cancer Research UK
ID : C8197/A16565
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA116167
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148537
Pays : United States
Organisme : Wellcome Trust
ID : 203477/Z/16/Z
Pays : United Kingdom

Investigateurs

Kristine K Sahlberg (KK)
Anne-Lise Børresen-Dale (AL)
Lars Ottestad (L)
Rolf Kåresen (R)
Ellen Schlichting (E)
Marit Muri Holmen (MM)
Toril Sauer (T)
Vilde Haakensen (V)
Olav Engebråten (O)
Bjørn Naume (B)
Alexander Fosså (A)
Cecile E Kiserud (CE)
Kristin V Reinertsen (KV)
Åslaug Helland (Å)
Margit Riis (M)
Jürgen Geisler (J)
Grethe I Grenaker Alnaes (GI)
Deborah Marsh (D)
Rodney Scott (R)
Robert Baxter (R)
Desmond Yip (D)
Jane Carpenter (J)
Alison Davis (A)
Nirmala Pathmanathan (N)
Peter Simpson (P)
Dinny Graham (D)
Mythily Sachchithananthan (M)

Informations de copyright

© 2023. The Author(s).

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Auteurs

Stefanie H Mueller (SH)

Institute of Health Informatics, University College London, London, UK.

Alvina G Lai (AG)

Institute of Health Informatics, University College London, London, UK.

Maria Valkovskaya (M)

Division of Psychiatry, University College London, London, UK.

Kyriaki Michailidou (K)

Biostatistics Unit, The Cyprus Institute of Neurology and Genetics, 2371, Nicosia, Cyprus.
Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, 2371, Nicosia, Cyprus.
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.

Manjeet K Bolla (MK)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.

Qin Wang (Q)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.

Joe Dennis (J)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.

Michael Lush (M)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.

Zomoruda Abu-Ful (Z)

Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, 35254, Haifa, Israel.

Thomas U Ahearn (TU)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20850, USA.

Irene L Andrulis (IL)

Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.

Hoda Anton-Culver (H)

Department of Medicine, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, 92617, USA.

Natalia N Antonenkova (NN)

N.N. Alexandrov Research Institute of Oncology and Medical Radiology, 223040, Minsk, Belarus.

Volker Arndt (V)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

Kristan J Aronson (KJ)

Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, ON, K7L 3N6, Canada.

Annelie Augustinsson (A)

Department of Cancer Epidemiology, Clinical Sciences, Lund University, 222 42, Lund, Sweden.

Thais Baert (T)

Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, 3000, Louvain, Belgium.

Laura E Beane Freeman (LEB)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20850, USA.

Matthias W Beckmann (MW)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054, Erlangen, Germany.

Sabine Behrens (S)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

Javier Benitez (J)

Biomedical Network On Rare Diseases (CIBERER), 28029, Madrid, Spain.
Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain.

Marina Bermisheva (M)

Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, 450054, Russia.

Carl Blomqvist (C)

Department of Oncology, Helsinki University Hospital, University of Helsinki, 00290, Helsinki, Finland.
Department of Oncology, Örebro University Hospital, 70185, Örebro, Sweden.

Natalia V Bogdanova (NV)

N.N. Alexandrov Research Institute of Oncology and Medical Radiology, 223040, Minsk, Belarus.
Department of Radiation Oncology, Hannover Medical School, 30625, Hannover, Germany.
Gynaecology Research Unit, Hannover Medical School, 30625, Hannover, Germany.

Stig E Bojesen (SE)

Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.

Bernardo Bonanni (B)

Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, 20141, Milan, Italy.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), 69120, Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

Sara Y Brucker (SY)

Department of Gynecology and Obstetrics, University of Tübingen, 72076, Tübingen, Germany.

Saundra S Buys (SS)

Department of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, 84112, USA.

Jose E Castelao (JE)

Oncology and Genetics Unit, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, 36312, Vigo, Spain.

Tsun L Chan (TL)

Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong, China.
Department of Molecular Pathology, Hong Kong Sanatorium and Hospital, Hong Kong, China.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20850, USA.

Ji-Yeob Choi (JY)

Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, 03080, Korea.
Cancer Research Institute, Seoul National University, Seoul, 03080, Korea.
Institute of Health Policy and Management, Seoul National University Medical Research Center, Seoul, 03080, Korea.

Wendy K Chung (WK)

Departments of Pediatrics and Medicine, Columbia University, New York, NY, 10032, USA.

Sarah V Colonna (SV)

Department of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, 84112, USA.

Sten Cornelissen (S)

Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni Van Leeuwenhoek Hospital, Amsterdam, 1066 CX, The Netherlands.

Fergus J Couch (FJ)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.

Kamila Czene (K)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65, Stockholm, Sweden.

Mary B Daly (MB)

Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.

Peter Devilee (P)

Department of Pathology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Department of Human Genetics, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.

Thilo Dörk (T)

Gynaecology Research Unit, Hannover Medical School, 30625, Hannover, Germany.

Laure Dossus (L)

Nutrition and Metabolism Section, International Agency for Research On Cancer (IARC-WHO), 69372, Lyon, France.

Miriam Dwek (M)

School of Life Sciences, University of Westminster, London, W1W 6UW, UK.

Diana M Eccles (DM)

Faculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK.

Arif B Ekici (AB)

Institute of Human Genetics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054, Erlangen, Germany.

A Heather Eliassen (AH)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

Christoph Engel (C)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107, Leipzig, Germany.
LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, 04103, Leipzig, Germany.

D Gareth Evans (DG)

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9WL, UK.
North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9WL, UK.

Peter A Fasching (PA)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054, Erlangen, Germany.
David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.

Olivia Fletcher (O)

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW7 3RP, UK.

Henrik Flyger (H)

Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark.

Manuela Gago-Dominguez (M)

Genomic Medicine Group, International Cancer Genetics and Epidemiology Group, Fundación Pœblica Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, 15706, Santiago de Compostela, Spain.
Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA.

Yu-Tang Gao (YT)

Department of Epidemiology, Shanghai Cancer Institute, Shanghai, 20032, China.

Montserrat García-Closas (M)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20850, USA.

José A García-Sáenz (JA)

Medical Oncology Department, Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), 28040, Madrid, Spain.

Jeanine Genkinger (J)

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA.

Aleksandra Gentry-Maharaj (A)

Institute of Clinical Trials and Methodology, University College London, London, WC1V 6LJ, UK.

Felix Grassmann (F)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65, Stockholm, Sweden.
Health and Medical University, 14471, Potsdam, Germany.

Pascal Guénel (P)

Center for Research in Epidemiology and Population Health (CESP), Team Exposome and Heredity, INSERM, University Paris-Saclay, 94805, Villejuif, France.

Melanie Gündert (M)

Molecular Epidemiology Group, German Cancer Research Center (DKFZ), C08069120, Heidelberg, Germany.
Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, University of Heidelberg, 69120, Heidelberg, Germany.
Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.

Lothar Haeberle (L)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054, Erlangen, Germany.

Eric Hahnen (E)

Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.
Center for Integrated Oncology (CIO), Faculty of Medicine, University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.

Christopher A Haiman (CA)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.

Niclas Håkansson (N)

Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.

Per Hall (P)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65, Stockholm, Sweden.
Department of Oncology, 118 83, Sšdersjukhuset, Stockholm, Sweden.

Elaine F Harkness (EF)

Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9PT, UK.
Nightingale and Genesis Prevention Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, M23 9LT, UK.
NIHR Manchester Biomedical Research Unit, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9WL, UK.

Patricia A Harrington (PA)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.

Jaana M Hartikainen (JM)

Translational Cancer Research Area, University of Eastern Finland, 70210, Kuopio, Finland.
Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, 70210, Kuopio, Finland.

Mikael Hartman (M)

Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, 119077, Singapore.
Department of Surgery, National University Health System, Singapore, 119228, Singapore.

Alexander Hein (A)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054, Erlangen, Germany.

Weang-Kee Ho (WK)

Department of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia Campus, 43500, Semenyih, Selangor, Malaysia.
Breast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya, 47500, Selangor, Malaysia.

Maartje J Hooning (MJ)

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, 3015 GD, The Netherlands.

Reiner Hoppe (R)

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376, Stuttgart, Germany.
University of Tübingen, 72074, Tübingen, Germany.

John L Hopper (JL)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3010, Australia.

Richard S Houlston (RS)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK.

Anthony Howell (A)

Division of Cancer Sciences, University of Manchester, Manchester, M13 9PL, UK.

David J Hunter (DJ)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.

Dezheng Huo (D)

Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, 60637, USA.

Hidemi Ito (H)

Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan.
Division of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.

Motoki Iwasaki (M)

Division of Epidemiology, Center for Public Health Sciences, National Cancer Center Institute for Cancer Control, Tokyo, 104-0045, Japan.

Anna Jakubowska (A)

Department of Genetics and Pathology, Pomeranian Medical University, 71-252, Szczecin, Poland.
Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, 71-252, Szczecin, Poland.

Wolfgang Janni (W)

Department of Gynaecology and Obstetrics, University Hospital Ulm, 89075, Ulm, Germany.

Esther M John (EM)

Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94304, USA.

Michael E Jones (ME)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK.

Audrey Jung (A)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

Rudolf Kaaks (R)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

Daehee Kang (D)

Cancer Research Institute, Seoul National University, Seoul, 03080, Korea.
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, 03080, Korea.

Elza K Khusnutdinova (EK)

Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, 450054, Russia.
Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, 450000, Russia.

Sung-Won Kim (SW)

Department of Surgery, Daerim Saint Mary's Hospital, Seoul, 07442, Korea.

Cari M Kitahara (CM)

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.

Stella Koutros (S)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20850, USA.

Peter Kraft (P)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

Vessela N Kristensen (VN)

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0450, Oslo, Norway.
Department of Medical Genetics, Oslo University Hospital and University of Oslo, 0379, Oslo, Norway.

Katerina Kubelka-Sabit (K)

Department of Histopathology and Cytology, Clinical Hospital Acibadem Sistina, Skopje, 1000, Republic of North Macedonia.

Allison W Kurian (AW)

Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94304, USA.

Ava Kwong (A)

Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong, China.
Department of Surgery, The University of Hong Kong, Hong Kong, China.
Department of Surgery and Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China.

James V Lacey (JV)

Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA, 91010, USA.
City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, 91010, USA.

Diether Lambrechts (D)

VIB Center for Cancer Biology, 3001, Louvain, Belgium.
Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, 3000, Louvain, Belgium.

Loic Le Marchand (L)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA.

Jingmei Li (J)

Human Genetics Division, Genome Institute of Singapore, Singapore, 138672, Singapore.

Martha Linet (M)

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.

Wing-Yee Lo (WY)

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376, Stuttgart, Germany.
University of Tübingen, 72074, Tübingen, Germany.

Jirong Long (J)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.

Artitaya Lophatananon (A)

Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PL, UK.

Arto Mannermaa (A)

Translational Cancer Research Area, University of Eastern Finland, 70210, Kuopio, Finland.
Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, 70210, Kuopio, Finland.
Biobank of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.

Mehdi Manoochehri (M)

Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

Sara Margolin (S)

Department of Oncology, 118 83, Sšdersjukhuset, Stockholm, Sweden.
Department of Clinical Science and Education, Sšdersjukhuset, Karolinska Institutet, 118 83, Stockholm, Sweden.

Keitaro Matsuo (K)

Division of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan.

Dimitrios Mavroudis (D)

Department of Medical Oncology, University Hospital of Heraklion, 711 10, Heraklion, Greece.

Usha Menon (U)

Institute of Clinical Trials and Methodology, University College London, London, WC1V 6LJ, UK.

Kenneth Muir (K)

Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PL, UK.

Rachel A Murphy (RA)

School of Population and Public Health, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Cancer Control Research, BC Cancer, Vancouver, BC, V5Z 1L3, Canada.

Heli Nevanlinna (H)

Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, 00290, Helsinki, Finland.

William G Newman (WG)

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9WL, UK.
North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9WL, UK.

Dieter Niederacher (D)

Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, 40225, Düsseldorf, Germany.

Katie M O'Brien (KM)

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA.

Nadia Obi (N)

Institute for Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.

Kenneth Offit (K)

Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Olufunmilayo I Olopade (OI)

Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, 60637, USA.

Andrew F Olshan (AF)

Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Håkan Olsson (H)

Department of Cancer Epidemiology, Clinical Sciences, Lund University, 222 42, Lund, Sweden.

Sue K Park (SK)

Cancer Research Institute, Seoul National University, Seoul, 03080, Korea.
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, 03080, Korea.
Integrated Major in Innovative Medical Science, Seoul National University College of Medicine, Seoul, 03080, South Korea.

Alpa V Patel (AV)

Department of Population Science, American Cancer Society, Atlanta, GA, 30303, USA.

Achal Patel (A)

Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Charles M Perou (CM)

Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Julian Peto (J)

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.

Paul D P Pharoah (PDP)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.

Dijana Plaseska-Karanfilska (D)

Research Centre for Genetic Engineering and Biotechnology "Georgi D. Efremov", MASA, Skopje, 1000, Republic of North Macedonia.

Nadege Presneau (N)

School of Life Sciences, University of Westminster, London, W1W 6UW, UK.

Brigitte Rack (B)

Department of Gynaecology and Obstetrics, University Hospital Ulm, 89075, Ulm, Germany.

Paolo Radice (P)

Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale Dei Tumori (INT), 20133, Milan, Italy.

Dhanya Ramachandran (D)

Gynaecology Research Unit, Hannover Medical School, 30625, Hannover, Germany.

Muhammad U Rashid (MU)

Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, 54000, Pakistan.

Gad Rennert (G)

Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, 35254, Haifa, Israel.

Atocha Romero (A)

Medical Oncology Department, Hospital Universitario Puerta de Hierro, 28222, Madrid, Spain.

Kathryn J Ruddy (KJ)

Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA.

Matthias Ruebner (M)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054, Erlangen, Germany.

Emmanouil Saloustros (E)

Department of Oncology, University Hospital of Larissa, 411 10, Larissa, Greece.

Dale P Sandler (DP)

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA.

Elinor J Sawyer (EJ)

School of Cancer and Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, King's College London, London, SE1 9RT, UK.

Marjanka K Schmidt (MK)

Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni Van Leeuwenhoek Hospital, Amsterdam, 1066 CX, The Netherlands.
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni Van Leeuwenhoek Hospital, Amsterdam, 1066 CX, The Netherlands.

Rita K Schmutzler (RK)

Center for Familial Breast and Ovarian Cancer, Faculty of Medicine, University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.
Center for Integrated Oncology (CIO), Faculty of Medicine, University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.

Michael O Schneider (MO)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054, Erlangen, Germany.

Christopher Scott (C)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.

Mitul Shah (M)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.

Priyanka Sharma (P)

Department of Internal Medicine, Division of Medical Oncology, University of Kansas Medical Center, Westwood, KS, 66205, USA.

Chen-Yang Shen (CY)

Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan.
School of Public Health, China Medical University, Taichung, Taiwan.

Xiao-Ou Shu (XO)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.

Jacques Simard (J)

Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Québec City, QC, G1V 4G2, Canada.

Harald Surowy (H)

Molecular Epidemiology Group, German Cancer Research Center (DKFZ), C08069120, Heidelberg, Germany.
Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, University of Heidelberg, 69120, Heidelberg, Germany.

Rulla M Tamimi (RM)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, 10065, USA.

William J Tapper (WJ)

Faculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK.

Jack A Taylor (JA)

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA.
Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA.

Soo Hwang Teo (SH)

Breast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya, 47500, Selangor, Malaysia.
Department of Surgery, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Lauren R Teras (LR)

Department of Population Science, American Cancer Society, Atlanta, GA, 30303, USA.

Amanda E Toland (AE)

Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, 43210, USA.

Rob A E M Tollenaar (RAEM)

Department of Surgery, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.

Diana Torres (D)

Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Institute of Human Genetics, Pontificia Universidad Javeriana, 110231, Bogota, Colombia.

Gabriela Torres-Mejía (G)

Center for Population Health Research, National Institute of Public Health, 62100, Cuernavaca, Morelos, Mexico.

Melissa A Troester (MA)

Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Thérèse Truong (T)

Center for Research in Epidemiology and Population Health (CESP), Team Exposome and Heredity, INSERM, University Paris-Saclay, 94805, Villejuif, France.

Celine M Vachon (CM)

Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, 55905, USA.

Joseph Vijai (J)

Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Clarice R Weinberg (CR)

Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA.

Camilla Wendt (C)

Department of Clinical Science and Education, Sšdersjukhuset, Karolinska Institutet, 118 83, Stockholm, Sweden.

Robert Winqvist (R)

Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, 90570, Oulu, Finland.
Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, 90570, Oulu, Finland.

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.
Department of Surgical Sciences, Uppsala University, 751 05, Uppsala, Sweden.

Anna H Wu (AH)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.

Taiki Yamaji (T)

Division of Epidemiology, Center for Public Health Sciences, National Cancer Center Institute for Cancer Control, Tokyo, 104-0045, Japan.

Xiaohong R Yang (XR)

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20850, USA.

Jyh-Cherng Yu (JC)

Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan.

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.

Argyrios Ziogas (A)

Department of Medicine, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, 92617, USA.

Elad Ziv (E)

Department of Medicine, Diller Family Comprehensive Cancer Center, Institute for Human Genetics, UCSF Helen, University of California San Francisco, San Francisco, CA, 94115, USA.

Alison M Dunning (AM)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.

Douglas F Easton (DF)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.

Harry Hemingway (H)

Institute of Health Informatics, University College London, London, UK.
Health Data Research UK, University College London, London, UK.
University College London Hospitals Biomedical Research Centre (UCLH BRC), London, UK.
The Alan Turing Institute, London, UK.

Ute Hamann (U)

Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

Karoline B Kuchenbaecker (KB)

Division of Psychiatry, University College London, London, UK. k.kuchenbaecker@ucl.ac.uk.
UCL Genetics Institute, University College London, London, UK. k.kuchenbaecker@ucl.ac.uk.
ORCID: 0000-0001-9726-603X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Aggregation tests identify new gene...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Aggregation tests identify new gene...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Aggregation tests identify new gene...
questionsmedicales.fr › Personnes › Noirs › Aggregation tests identify new gene...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Services de médecine préventive › Services de diagnostic › Dépistage génétique › Aggregation tests identify new gene...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Aggregation tests identify new gene...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Aggregation tests identify new gene...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Formines › Aggregation tests identify new gene...