Endothelial cell CD36 mediates stroke-induced brain injury via BBB dysfunction and monocyte infiltration in normal and obese conditions.
Endothelial CD36
infiltration
ischemic stroke
monocyte-derived macrophages
obesity
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
pmc-release:
26
01
2024
medline:
18
5
2023
pubmed:
28
1
2023
entrez:
27
1
2023
Statut:
ppublish
Résumé
CD36 expressed in multiple cell types regulates inflammation, vascular function, and innate immunity. Specifically, CD36 in microvascular endothelial cells (ECs) signals to elicit inflammation and causes EC death. This study investigated roles for EC-CD36 on acute stroke pathology in normal and obese conditions. Obesity induced by a high-fat diet (HD) selectively increased CD36 expression in ECs, not in monocytes/macrophages, in the post-ischemic brain. Mice deficient CD36 in ECs (EC
Identifiants
pubmed: 36703604
doi: 10.1177/0271678X231154602
pmc: PMC10196754
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
843-855Subventions
Organisme : NINDS NIH HHS
ID : R01 NS095359
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103326
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS111568
Pays : United States
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