Endoplasmic reticulum as a target in cardiovascular diseases: Is there a role for flavonoids?
cardiovascular diseases
endoplasmic reticulum stress
flavonoids
kaempferol
quercetin
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
09
2022
accepted:
19
12
2022
entrez:
27
1
2023
pubmed:
28
1
2023
medline:
28
1
2023
Statut:
epublish
Résumé
Flavonoids are found in natural health products and plant-based foods. The flavonoid molecules contain a 15-carbon skeleton with the particular structural construction of subclasses. The most flavonoid's critical subclasses with improved health properties are the catechins or flavonols (e.g., epigallocatechin 3-gallate from green tea), the flavones (e.g., apigenin from celery), the flavanones (e.g., naringenin from citrus), the flavanols (e.g., quercetin glycosides from berries, onion, and apples), the isoflavones (e.g., genistein from soya beans) and the anthocyanins (e.g., cyanidin-3-O-glucoside from berries). Scientific data conclusively demonstrates that frequent intake of efficient amounts of dietary flavonoids decreases chronic inflammation and the chance of oxidative stress expressing the pathogenesis of human diseases like cardiovascular diseases (CVDs). The endoplasmic reticulum (ER) is a critical organelle that plays a role in protein folding, post-transcriptional conversion, and transportation, which plays a critical part in maintaining cell homeostasis. Various stimuli can lead to the creation of unfolded or misfolded proteins in the endoplasmic reticulum and then arise in endoplasmic reticulum stress. Constant endoplasmic reticulum stress triggers unfolded protein response (UPR), which ultimately causes apoptosis. Research has shown that endoplasmic reticulum stress plays a critical part in the pathogenesis of several cardiovascular diseases, including diabetic cardiomyopathy, ischemic heart disease, heart failure, aortic aneurysm, and hypertension. Endoplasmic reticulum stress could be one of the crucial points in treating multiple cardiovascular diseases. In this review, we summarized findings on flavonoids' effects on the endoplasmic reticulum and their role in the prevention and treatment of cardiovascular diseases.
Identifiants
pubmed: 36703744
doi: 10.3389/fphar.2022.1027633
pii: 1027633
pmc: PMC9871646
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1027633Informations de copyright
Copyright © 2023 Keylani, Arbab Mojeni, Khalaji, Rasouli, Aminzade, Karimi, Sanaye, Khajevand, Nemayandeh, Poudineh, Azizabadi Farahani, Esfandiari, Haghshoar, Kheirandish, Amouei, Abdi, Azizinezhad, Khani and Deravi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Biol Pharm Bull. 2015;38(12):1873-8
pubmed: 26632179
Oxid Med Cell Longev. 2019 Mar 10;2019:5484138
pubmed: 30962863
PLoS One. 2011;6(11):e27294
pubmed: 22073308
Cardiovasc Res. 2011 Aug 1;91(3):447-55
pubmed: 21493701
Tumour Biol. 2016 Jul;37(7):8471-86
pubmed: 27059734
Hepatology. 2017 May;65(5):1720-1734
pubmed: 28090670
Neural Regen Res. 2015 Aug;10(8):1239-44
pubmed: 26487850
Free Radic Res. 2012 Feb;46(2):154-63
pubmed: 22145946
Atherosclerosis. 2011 Feb;214(2):415-21
pubmed: 21168844
Circulation. 1997 Sep 16;96(6):1745-9
pubmed: 9323056
Proc Nutr Soc. 2010 Aug;69(3):273-8
pubmed: 20569521
J Pharmacol Exp Ther. 1995 Mar;272(3):1095-100
pubmed: 7891321
Sci Rep. 2018 Jan 29;8(1):1818
pubmed: 29379034
Basic Clin Pharmacol Toxicol. 2016 Oct;119 Suppl 3:42-48
pubmed: 26919268
Apoptosis. 2016 Jul;21(7):809-24
pubmed: 27170343
Circ Cardiovasc Genet. 2011 Jun;4(3):243-52
pubmed: 21493819
J Immunol. 2009 Jul 15;183(2):1480-7
pubmed: 19561103
Acta Pharmacol Sin. 2015 Jul;36(7):821-30
pubmed: 26005910
Oxid Med Cell Longev. 2018 Nov 21;2018:1610751
pubmed: 30584457
Oxid Med Cell Longev. 2018 Jan 11;2018:7239123
pubmed: 29576853
Am J Physiol. 1995 Jan;268(1 Pt 1):C271-7
pubmed: 7840156
Annu Rev Pathol. 2008;3:399-425
pubmed: 18039139
Cell. 2010 Mar 19;140(6):900-17
pubmed: 20303879
Arch Pharm Res. 2020 Aug;43(8):808-820
pubmed: 32761308
Mol Pharmacol. 2012 Nov;82(5):993-1000
pubmed: 22918967
J Med Phys. 2017 Oct-Dec;42(4):245-250
pubmed: 29296039
Free Radic Biol Med. 2016 Oct;99:1-10
pubmed: 27458123
Oxid Med Cell Longev. 2021 Mar 29;2021:5529913
pubmed: 33859776
Sci Rep. 2022 Jul 25;12(1):12681
pubmed: 35879337
Immunopharmacol Immunotoxicol. 2008;30(2):257-70
pubmed: 18569083
Biochem Biophys Res Commun. 2001 Jun 15;284(3):681-8
pubmed: 11396955
Curr Opin Lipidol. 2001 Oct;12(5):535-41
pubmed: 11561173
Molecules. 2018 Oct 10;23(10):
pubmed: 30309003
J Med Phys. 2017 Oct-Dec;42(4):241-244
pubmed: 29296038
Nutrients. 2014 Jan 21;6(1):391-415
pubmed: 24451310
Cell Physiol Biochem. 2017;41(6):2503-2512
pubmed: 28472796
Curr Hypertens Rep. 2004 Dec;6(6):424-9
pubmed: 15527685
Cell Metab. 2012 Aug 8;16(2):250-64
pubmed: 22883233
Cardiovasc Ther. 2012 Dec;30(6):317-25
pubmed: 21884021
Arterioscler Thromb Vasc Biol. 2011 May;31(5):1124-32
pubmed: 21330607
Acta Pharmacol Sin. 2016 Apr;37(4):425-43
pubmed: 26838072
Int J Med Sci. 2011;8(7):564-72
pubmed: 21960749
Int J Vasc Med. 2017;2017:2049217
pubmed: 28875043
Mol Med Rep. 2018 Jan;17(1):374-381
pubmed: 29115422
J Physiol Biochem. 2019 Feb;75(1):83-88
pubmed: 30539499
Int J Mol Sci. 2016 Feb 01;17(2):
pubmed: 26840309
Cell Metab. 2009 May;9(5):474-81
pubmed: 19416717
Int Immunopharmacol. 2019 Aug;73:98-107
pubmed: 31082728
J Pharm Pharmacol. 2019 Mar;71(3):400-407
pubmed: 30456794
Mol Ther. 2018 Jun 6;26(6):1404-1413
pubmed: 29728295
FASEB J. 2003 Jul;17(10):1307-9
pubmed: 12759336
Mol Nutr Food Res. 2014 May;58(5):954-62
pubmed: 24347345
Int J Cardiol. 2016 Jan 15;203:282-9
pubmed: 26519687
Oxid Med Cell Longev. 2020 Jun 15;2020:4530278
pubmed: 32655768
Cardiovasc Ther. 2017 Feb;35(1):33-39
pubmed: 27809414
J Neurochem. 2001 Nov;79(4):719-25
pubmed: 11723164
Oxid Med Cell Longev. 2019 Jan 8;2019:7670854
pubmed: 30728891
Eur J Pharmacol. 2014 Dec 15;745:59-68
pubmed: 25446924
N Engl J Med. 1999 Jan 14;340(2):115-26
pubmed: 9887164
Acta Cardiol Sin. 2016 Jan;32(1):81-8
pubmed: 27122935
Food Funct. 2019 May 22;10(5):2752-2765
pubmed: 31041965
Trends Cardiovasc Med. 2013 Oct;23(7):264-8
pubmed: 23541171
Biomed Res Int. 2015;2015:724876
pubmed: 26640794
Biophys Rev. 2017 Apr;9(2):139-148
pubmed: 28510090
Front Pharmacol. 2017 Feb 27;8:71
pubmed: 28289383
PLoS One. 2014 Feb 10;9(2):e88389
pubmed: 24520378
Cell Signal. 2014 Dec;26(12):2591-600
pubmed: 25152364
Cell Physiol Biochem. 2017;41(3):999-1010
pubmed: 28222421
Mol Med. 2011 Mar-Apr;17(3-4):201-10
pubmed: 21152695
Cell Physiol Biochem. 2017;42(4):1313-1325
pubmed: 28700997
Molecules. 2021 Apr 02;26(7):
pubmed: 33918290
Int J Mol Sci. 2013 Aug 30;14(9):17845-60
pubmed: 23999590
Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E539-E550
pubmed: 33459180
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2016 Jan;32(1):51-4
pubmed: 27255042
Antioxid Redox Signal. 2013 Jul 10;19(2):151-62
pubmed: 23121441
J Agric Food Chem. 2018 Aug 8;66(31):8291-8298
pubmed: 30040414
Circ Res. 2011 Mar 4;108(5):629-42
pubmed: 21372294
Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1398-408
pubmed: 12234790
Biochem Pharmacol. 2015 Oct 1;97(3):256-68
pubmed: 26275811
Life Sci. 2018 Jun 15;203:246-254
pubmed: 29705352
Circ Res. 2010 Feb 5;106(2):307-16
pubmed: 19940266
J Clin Invest. 2012 Jun;122(6):2104-13
pubmed: 22565308
J Physiol Biochem. 2014 Jun;70(2):407-15
pubmed: 24526395
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1657-E1666
pubmed: 29378958
Nat Rev Cardiol. 2021 Jul;18(7):499-521
pubmed: 33619348
Mol Cell Biochem. 2017 Jan;424(1-2):111-122
pubmed: 27785700
Biol Pharm Bull. 2021;44(12):1894-1897
pubmed: 34853274
J Pharmacol Exp Ther. 2021 Apr;377(1):146-156
pubmed: 33509902
EBioMedicine. 2018 Oct;36:18-28
pubmed: 30279143
Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1471-86
pubmed: 21803944
Mol Med Rep. 2015 Nov;12(5):7545-53
pubmed: 26398703
PLoS One. 2017 May 31;12(5):e0178365
pubmed: 28562691
Free Radic Biol Med. 2019 Sep;141:67-83
pubmed: 31153974
Mol Cell Biol. 2004 Dec;24(23):10161-8
pubmed: 15542827
Biosci Trends. 2012 Feb;6(1):19-25
pubmed: 22426099
FASEB J. 2011 Aug;25(8):2583-91
pubmed: 21507899
Cell Death Differ. 2007 Jan;14(1):10-22
pubmed: 16977329
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1472-1482
pubmed: 31176760
J Pharm Pharmacol. 2021 Jul 7;73(8):1023-1032
pubmed: 34018553
J Biochem Mol Toxicol. 2006;20(4):191-7
pubmed: 16906524
Phytother Res. 2020 May;34(5):911-923
pubmed: 31829475
Med Sci Monit. 2017 Jun 16;23:2939-2948
pubmed: 28622281
Exp Ther Med. 2018 Aug;16(2):867-873
pubmed: 30112041
J Cell Sci. 2006 Dec 1;119(Pt 23):4913-25
pubmed: 17105775
Circ Res. 1989 Aug;65(2):334-42
pubmed: 2546695
Antioxid Redox Signal. 2015 Mar 10;22(8):633-50
pubmed: 25365634
Peptides. 2013 Oct;48:156-65
pubmed: 23994559
Int Immunopharmacol. 2019 Jul;72:413-421
pubmed: 31030097
Vascul Pharmacol. 2016 Oct;85:39-49
pubmed: 27473516
Mutat Res. 2005 Jan 6;569(1-2):29-63
pubmed: 15603751
Mol Cell. 2002 Aug;10(2):417-26
pubmed: 12191486
Mol Neurobiol. 2015;51(3):1343-52
pubmed: 25048984
Int J Mol Med. 2011 Apr;27(4):503-9
pubmed: 21305250
Int J Mol Sci. 2017 May 15;18(5):
pubmed: 28505121
Biomed Pharmacother. 2018 Aug;104:193-203
pubmed: 29772440
Int Heart J. 2014;55(2):101-5
pubmed: 24632952
Biochem Biophys Res Commun. 2018 Feb 5;496(2):731-737
pubmed: 29406244
Curr Pharm Des. 2012;18(28):4266-88
pubmed: 22390643
J Pharm Pharmacol. 2010 Feb;62(2):197-204
pubmed: 20487199
Pharmacol Rep. 2015 Dec;67(6):1090-7
pubmed: 26481526
J Physiol Biochem. 2016 Jun;72(2):303-13
pubmed: 27000882
Circ Res. 2010 Oct 1;107(7):839-50
pubmed: 20884885
Circulation. 2002 Mar 5;105(9):1135-43
pubmed: 11877368
Curr Issues Mol Biol. 2018;28:14-28
pubmed: 29388553
Diabetes. 2000 Dec;49(12):2063-9
pubmed: 11118008
Int J Antimicrob Agents. 2005 Nov;26(5):343-56
pubmed: 16323269
Oxid Med Cell Longev. 2015;2015:481405
pubmed: 26265983
Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29
pubmed: 17565364
Br J Pharmacol. 2017 Jul;174(13):2140-2151
pubmed: 28436023
Antioxid Redox Signal. 2017 Jan 1;26(1):15-27
pubmed: 27392575
Food Funct. 2019 Jan 22;10(1):203-215
pubmed: 30525169
Oxid Med Cell Longev. 2020 Sep 9;2020:9270107
pubmed: 32963706
J Environ Pathol Toxicol Oncol. 2014;33(4):363-76
pubmed: 25404382
Phytother Res. 2022 Jan;36(1):73-84
pubmed: 34528309
Food Funct. 2018 Apr 25;9(4):2386-2397
pubmed: 29594285
Nat Cell Biol. 2006 Nov;8(11):1255-62
pubmed: 17028579
Int J Mol Sci. 2018 May 30;19(6):
pubmed: 29848965
Biochim Biophys Acta. 2012 Dec;1820(12):2052-61
pubmed: 23022152
Oxid Med Cell Longev. 2017;2017:9536148
pubmed: 28386313
Eur Heart J. 2013 Jun;34(24):1834-45
pubmed: 22307460
DNA Cell Biol. 2019 Aug;38(8):796-807
pubmed: 31295012
Sci Rep. 2015 May 15;5:10340
pubmed: 25976123
Nat Immunol. 2005 Aug;6(8):777-84
pubmed: 16007092
Cell Death Dis. 2018 May 23;9(6):612
pubmed: 29795235
Exp Mol Pathol. 2015 Dec;99(3):449-54
pubmed: 26318286
EMBO J. 2005 Mar 23;24(6):1243-55
pubmed: 15775988
PLoS One. 2017 Jun 7;12(6):e0179042
pubmed: 28591178