Oxidative homeostasis in follicular fluid and reproductive outcomes - from bench to bedside.
assisted reproductive techniques
follicular fluid
in vitro fertilization
oxidant
reactive-oxygen species
Journal
Przeglad menopauzalny = Menopause review
ISSN: 1643-8876
Titre abrégé: Prz Menopauzalny
Pays: Poland
ID NLM: 101263235
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
12
02
2022
accepted:
31
03
2022
entrez:
27
1
2023
pubmed:
28
1
2023
medline:
28
1
2023
Statut:
ppublish
Résumé
Free radicals and oxidant molecules are part of our organism in a stable balance. However, when addressing female infertility, questions about their role in oocyte quality arise. This review outlines the major alterations of redox homeostasis in the follicular fluid through pathophysiological conditions in female reproduction and its potential effect on IVF outcome. A review of the literature was accurately performed. Manuscripts investigating follicular fluid biomarkers, especially related to oxidant molecules, were screened and used in this review. Studies assessing the follicular reactive species were found and screened. Moreover, studies assessing the IVF outcomes related to biomarkers were considered. The results are provided in an analytical pathway. The study of biomarkers confirms the shift to enhanced oxidizing modification of macromolecules and antioxidative consumption in the follicular fluid of women undergoing IVF treatment. A lack of congruency in methods appears to be marked in the design of scientific studies. However, it is not clear whether redox disbalance has a disruptive effect on the oocyte competence or whether it plays a role in the oocyte maturation process. Red-ox balance plays a questionable role in IVF outcomes. Possible further insights may consider the antioxidant role of adjuvants during controlled ovarian stimulation cycles.
Identifiants
pubmed: 36704764
doi: 10.5114/pm.2022.124019
pii: 49875
pmc: PMC9872000
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
276-284Informations de copyright
Copyright © 2022 Termedia.
Déclaration de conflit d'intérêts
The authors report no conflict of interest.
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