A nutritional supplement containing zinc during preconception and pregnancy increases human milk zinc concentrations.
human milk
minerals
pregnancy
supplement
zinc
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
09
2022
accepted:
12
12
2022
entrez:
27
1
2023
pubmed:
28
1
2023
medline:
28
1
2023
Statut:
epublish
Résumé
During pregnancy and lactation minerals such as zinc are required to support maternal and infant health. Zinc is involved in various cellular processes, with requirements increasing in pregnancy and lactation. In the setting of a randomized trial, we investigated the effects on human milk (HM) zinc concentrations of a micronutrient-containing supplement including zinc in the intervention (but not control) group, started preconception and taken throughout pregnancy until birth. Additionally, we characterized longitudinal changes in HM concentrations of zinc and other minerals (calcium, copper, iodine, iron, magnesium, manganese, phosphorus, potassium, selenium, and sodium). HM samples were collected across 7 time points from 1 week to 12 months from lactating mothers from Singapore ( Over the first 3 months of lactation, HM zinc concentrations were 11% higher in the intervention group compared to the control group ( Overall, this study indicates that HM zinc concentrations are influenced by maternal supplementation during preconception and pregnancy. Further studies are required to understand the associations between HM zinc and other minerals and both short- and long-term offspring outcomes. ClinicalTrials.gov, identifier: NCT02509988, Universal Trial Number U1111-1171-8056. Registered on 16 July 2015. This is an academic-led study by the EpiGen Global Research Consortium.
Identifiants
pubmed: 36704795
doi: 10.3389/fnut.2022.1034828
pmc: PMC9872665
doi:
Banques de données
ClinicalTrials.gov
['NCT02509988']
Types de publication
Journal Article
Langues
eng
Pagination
1034828Subventions
Organisme : Medical Research Council
ID : MC_UP_A620_1015
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12011/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_A620_1014
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_21003
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400491
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U147585819
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_21022
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12011/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_21000
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U147585827
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U147585824
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_21001
Pays : United Kingdom
Investigateurs
Benjamin B Albert
(BB)
Shelia J Barton
(SJ)
Mary Cavanagh
(M)
Hsin Fang Chang
(HF)
Yap Seng Chong
(YS)
Mary F Chong
(MF)
Cathryn Conlon
(C)
Cyrus Cooper
(C)
Paula Costello
(P)
Vanessa Cox
(V)
Christine Creagh
(C)
Marysia Depczynski
(M)
Sarah El-Heis
(S)
Judith Hammond
(J)
Nicholas C Harvey
(NC)
Mrunalini Jagtap
(M)
Timothy Kenealy
(T)
Heidi Nield
(H)
Justin M O'Sullivan
(JM)
Gernalia Satianegara
(G)
Irma Silva-Zolezzi
(I)
Shu E Soh
(SE)
Vicky Tay
(V)
Rachael Taylor
(R)
Elizabeth Tham
(E)
Philip Titcombe
(P)
Clare Wall
(C)
Ray Wong
(R)
Gladys Woon
(G)
Informations de copyright
Copyright © 2023 Han, Devaraj, Derraik, Vickers, Huang, Dubascoux, Godfrey, Chan, Pang, Thakkar, Cutfield and NiPPeR Study Group.
Déclaration de conflit d'intérêts
KMG, S-YC, and WSC are part of an academic consortium that has received grants from Société des Produits Nestlé SA relating to the submitted work, and from Abbott Nutrition, Danone, and BenevolentAI Bio Ltd. outside the submitted work, and are co-inventors on patent filings by Société des Produits Nestlé SA relating to the NiPPeR intervention or its components. FH, SDe, SDu, and SKT are employees of Société des Produits Nestlé SA. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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