Migraine, inflammatory bowel disease and celiac disease: A Mendelian randomization study.
Mendelian randomization
celiac disease
gastrointestinal disease
genetic correlation
inflammatory bowel disease
migraine
Journal
Headache
ISSN: 1526-4610
Titre abrégé: Headache
Pays: United States
ID NLM: 2985091R
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
revised:
01
12
2022
received:
02
05
2022
accepted:
05
12
2022
medline:
16
5
2023
pubmed:
28
1
2023
entrez:
27
1
2023
Statut:
ppublish
Résumé
To assess whether migraine may be genetically and/or causally associated with inflammatory bowel disease (IBD) or celiac disease. Migraine has been linked to IBD and celiac disease in observational studies, but whether this link may be explained by a shared genetic basis or could be causal has not been established. The presence of a causal association could be clinically relevant, as treating one of these medical conditions might mitigate the symptoms of a causally linked condition. Linkage disequilibrium score regression and two-sample bidirectional Mendelian randomization analyses were performed using summary statistics from cohort-based genome-wide association studies of migraine (59,674 cases; 316,078 controls), IBD (25,042 cases; 34,915 controls) and celiac disease (11,812 or 4533 cases; 11,837 or 10,750 controls). Migraine with and without aura were analyzed separately, as were the two IBD subtypes Crohn's disease and ulcerative colitis. Positive control analyses and conventional Mendelian randomization sensitivity analyses were performed. Migraine was not genetically correlated with IBD or celiac disease. No evidence was observed for IBD (odds ratio [OR] 1.00, 95% confidence interval [CI] 0.99-1.02, p = 0.703) or celiac disease (OR 1.00, 95% CI 0.99-1.02, p = 0.912) causing migraine or migraine causing either IBD (OR 1.08, 95% CI 0.96-1.22, p = 0.181) or celiac disease (OR 1.08, 95% CI 0.79-1.48, p = 0.614) when all participants with migraine were analyzed jointly. There was some indication of a causal association between celiac disease and migraine with aura (OR 1.04, 95% CI 1.00-1.08, p = 0.045), between celiac disease and migraine without aura (OR 0.95, 95% CI 0.92-0.99, p = 0.006), as well as between migraine without aura and ulcerative colitis (OR 1.15, 95% CI 1.02-1.29, p = 0.025). However, the results were not significant after multiple testing correction. We found no evidence of a shared genetic basis or of a causal association between migraine and either IBD or celiac disease, although we obtained some indications of causal associations with migraine subtypes.
Sections du résumé
OBJECTIVE
To assess whether migraine may be genetically and/or causally associated with inflammatory bowel disease (IBD) or celiac disease.
BACKGROUND
Migraine has been linked to IBD and celiac disease in observational studies, but whether this link may be explained by a shared genetic basis or could be causal has not been established. The presence of a causal association could be clinically relevant, as treating one of these medical conditions might mitigate the symptoms of a causally linked condition.
METHODS
Linkage disequilibrium score regression and two-sample bidirectional Mendelian randomization analyses were performed using summary statistics from cohort-based genome-wide association studies of migraine (59,674 cases; 316,078 controls), IBD (25,042 cases; 34,915 controls) and celiac disease (11,812 or 4533 cases; 11,837 or 10,750 controls). Migraine with and without aura were analyzed separately, as were the two IBD subtypes Crohn's disease and ulcerative colitis. Positive control analyses and conventional Mendelian randomization sensitivity analyses were performed.
RESULTS
Migraine was not genetically correlated with IBD or celiac disease. No evidence was observed for IBD (odds ratio [OR] 1.00, 95% confidence interval [CI] 0.99-1.02, p = 0.703) or celiac disease (OR 1.00, 95% CI 0.99-1.02, p = 0.912) causing migraine or migraine causing either IBD (OR 1.08, 95% CI 0.96-1.22, p = 0.181) or celiac disease (OR 1.08, 95% CI 0.79-1.48, p = 0.614) when all participants with migraine were analyzed jointly. There was some indication of a causal association between celiac disease and migraine with aura (OR 1.04, 95% CI 1.00-1.08, p = 0.045), between celiac disease and migraine without aura (OR 0.95, 95% CI 0.92-0.99, p = 0.006), as well as between migraine without aura and ulcerative colitis (OR 1.15, 95% CI 1.02-1.29, p = 0.025). However, the results were not significant after multiple testing correction.
CONCLUSIONS
We found no evidence of a shared genetic basis or of a causal association between migraine and either IBD or celiac disease, although we obtained some indications of causal associations with migraine subtypes.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
642-651Subventions
Organisme : Åke Wiberg Stiftelse
Organisme : Marcus Borgströms Stiftelse
Organisme : Svenska Läkaresällskapet
ID : SLS-935235
Organisme : Svenska Sällskapet för Medicinsk Forskning
ID : SSMF 30072019
Organisme : Vetenskapsrådet
ID : 2019-01066
Organisme : Vleugels Stiftelse
Investigateurs
Padhraig Gormley
(P)
Verneri Anttila
(V)
Bendik S Winsvold
(BS)
Priit Palta
(P)
Tonu Esko
(T)
Tune H Pers
(TH)
Kai-How Farh
(KH)
Ester Cuenca-Leon
(E)
Mikko Muona
(M)
Nicholas A Furlotte
(NA)
Tobias Kurth
(T)
Andres Ingason
(A)
George McMahon
(G)
Lannie Ligthart
(L)
Gisela M Terwindt
(GM)
Mikko Kallela
(M)
Tobias M Freilinger
(TM)
Caroline Ran
(C)
Scott G Gordon
(SG)
Anine H Stam
(AH)
Stacy Steinberg
(S)
Guntram Borck
(G)
Markku Koiranen
(M)
Lydia Quaye
(L)
Hieab H H Adams
(HHH)
Terho Lehtimäki
(T)
Antti-Pekka Sarin
(AP)
Juho Wedenoja
(J)
David A Hinds
(DA)
Julie E Buring
(JE)
Markus Schürks
(M)
Paul M Ridker
(PM)
Maria Gudlaug Hrafnsdottir
(MG)
Hreinn Stefansson
(H)
Susan M Ring
(SM)
Jouke-Jan Hottenga
(JJ)
Brenda W J H Penninx
(BWJH)
Markus Färkkilä
(M)
Ville Artto
(V)
Mari Kaunisto
(M)
Salli Vepsäläinen
(S)
Rainer Malik
(R)
Andrew C Heath
(AC)
Pamela A F Madden
(PAF)
Nicholas G Martin
(NG)
Grant W Montgomery
(GW)
Mitja Kurki
(M)
Mart Kals
(M)
Reedik Mägi
(R)
Kalle Pärn
(K)
Eija Hämäläinen
(E)
Hailiang Huang
(H)
Andrea E Byrnes
(AE)
Lude Franke
(L)
Jie Huang
(J)
Evie Stergiakouli
(E)
Phil H Lee
(PH)
Cynthia Sandor
(C)
Caleb Webber
(C)
Zameel Cader
(Z)
Bertram Muller-Myhsok
(B)
Stefan Schreiber
(S)
Thomas Meitinger
(T)
Johan G Eriksson
(JG)
Veikko Salomaa
(V)
Kauko Heikkilä
(K)
Elizabeth Loehrer
(E)
Andre G Uitterlinden
(AG)
Albert Hofman
(A)
Cornelia M van Duijn
(CM)
Lynn Cherkas
(L)
Linda M Pedersen
(LM)
Audun Stubhaug
(A)
Christopher S Nielsen
(CS)
Minna Männikö
(M)
Evelin Mihailov
(E)
Lili Milani
(L)
Hartmut Göbel
(H)
Ann-Louise Esserlind
(AL)
Anne Francke Christensen
(AF)
Thomas Folkmann Hansen
(TF)
Thomas Werge
(T)
Sigrid Børte
(S)
Bru Cormand
(B)
Else Eising
(E)
Lyn Griffiths
(L)
Eija Hamalainen
(E)
Marjo Hiekkala
(M)
Risto Kajanne
(R)
Lenore Launer
(L)
Terho Lehtimaki
(T)
Davor Lessel
(D)
Alfons Macaya
(A)
Massimo Mangino
(M)
Nancy Pedersen
(N)
Danielle Posthuma
(D)
Patricia Pozo-Rosich
(P)
Alice Pressman
(A)
Celia Sintas
(C)
Marta Vila-Pueyo
(M)
Huiying Zhao
(H)
Jaakko Kaprio
(J)
Arpo J Aromaa
(AJ)
Olli Raitakari
(O)
M Arfan Ikram
(MA)
Tim Spector
(T)
Marjo-Riitta Järvelin
(MR)
Andres Metspalu
(A)
Christian Kubisch
(C)
David P Strachan
(DP)
Michel D Ferrari
(MD)
Andrea C Belin
(AC)
Martin Dichgans
(M)
Maija Wessman
(M)
Arn M J M van den Maagdenberg
(AMJM)
John-Anker Zwart
(JA)
Dorret I Boomsma
(DI)
George Davey Smith
(GD)
Kari Stefansson
(K)
Nicholas Eriksson
(N)
Mark J Daly
(MJ)
Benjamin M Neale
(BM)
Jes Olesen
(J)
Daniel I Chasman
(DI)
Dale R Nyholt
(DR)
Aarno Palotie
(A)
Informations de copyright
© 2023 The Authors. Headache: The Journal of Head and Face Pain published by Wiley Periodicals LLC on behalf of American Headache Society.
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