Longitudinal relationship between albuminuria in infancy and childhood.
Albumin-creatinine ratio
Albuminuria
Children
Epidemiology
Microalbuminuria
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
08
07
2022
accepted:
02
10
2022
revised:
01
10
2022
medline:
4
8
2023
pubmed:
28
1
2023
entrez:
27
1
2023
Statut:
ppublish
Résumé
Mildly increased albuminuria is common in the general adult population and is a strong predictor for cardiovascular events, even in otherwise healthy individuals. The underlying pathophysiological process could be endothelial dysfunction. Previously, we reported that increased albuminuria can also be found in 2-year-olds from the general population. We hypothesized that some individuals have constitutionally higher levels of albuminuria, possibly as an expression of early or inborn endothelial dysfunction. The aim of this study is to evaluate longitudinal persistence of albuminuria from infancy into school age. In the population-based GECKO (Groningen Expert Center for Kids with Obesity) cohort, urine was collected from 816 children at the age of 2 years as well as 12 years (random urine and first morning void urine, respectively). We evaluated prevalence and persistence of increased albuminuria (U The prevalence of U Albuminuria in 2-year-olds does largely not persist until the age of 12, indicating that albuminuria at 2 years of age is not a marker for constitutional endothelial dysfunction in this cohort. A higher resolution version of the Graphical abstract is available as Supplementary information.
Sections du résumé
BACKGROUND
Mildly increased albuminuria is common in the general adult population and is a strong predictor for cardiovascular events, even in otherwise healthy individuals. The underlying pathophysiological process could be endothelial dysfunction. Previously, we reported that increased albuminuria can also be found in 2-year-olds from the general population. We hypothesized that some individuals have constitutionally higher levels of albuminuria, possibly as an expression of early or inborn endothelial dysfunction. The aim of this study is to evaluate longitudinal persistence of albuminuria from infancy into school age.
METHODS
In the population-based GECKO (Groningen Expert Center for Kids with Obesity) cohort, urine was collected from 816 children at the age of 2 years as well as 12 years (random urine and first morning void urine, respectively). We evaluated prevalence and persistence of increased albuminuria (U
RESULTS
The prevalence of U
CONCLUSION
Albuminuria in 2-year-olds does largely not persist until the age of 12, indicating that albuminuria at 2 years of age is not a marker for constitutional endothelial dysfunction in this cohort. A higher resolution version of the Graphical abstract is available as Supplementary information.
Identifiants
pubmed: 36705757
doi: 10.1007/s00467-022-05850-5
pii: 10.1007/s00467-022-05850-5
pmc: PMC10393842
doi:
Substances chimiques
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2897-2900Informations de copyright
© 2023. The Author(s).
Références
Lancet. 2010 Jun 12;375(9731):2073-81
pubmed: 20483451
Kidney Int. 2011 Jun;79(12):1341-52
pubmed: 21307840
Pediatr Nephrol. 2010 Jun;25(6):1131-7
pubmed: 20165888
Kidney Int. 2011 Jun;79(12):1331-40
pubmed: 21289598
Kidney Int. 2011 Jul;80(1):93-104
pubmed: 21289597
Kidney Int Suppl. 2004 Nov;(92):S18-21
pubmed: 15485409
Am J Kidney Dis. 2002 Mar;39(3):445-59
pubmed: 11877563
Kidney Int Suppl. 2004 Nov;(92):S22-4
pubmed: 15485411
Nephrol Dial Transplant. 2013 Jul;28(7):1794-801
pubmed: 23493327
Nephrol Dial Transplant. 2016 Oct;31(10):1686-92
pubmed: 26705193
Int J Epidemiol. 2008 Jun;37(3):486-9
pubmed: 18238823
J Intern Med. 2001 Jun;249(6):519-26
pubmed: 11422658
Circulation. 2005 Aug 16;112(7):969-75
pubmed: 16087792