C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance.

Humans Citrulline Arthritis, Rheumatoid Immune Tolerance Peptides Cell Communication

Journal

Journal of autoimmunity
ISSN: 1095-9157
Titre abrégé: J Autoimmun
Pays: England
ID NLM: 8812164

Informations de publication

Date de publication:
02 2023
Historique:
received: 07 10 2022
revised: 03 12 2022
accepted: 05 01 2023
pubmed: 28 1 2023
medline: 3 3 2023
entrez: 27 1 2023
Statut: ppublish

Résumé

In rheumatoid arthritis, the emergence of anti-citrullinated autoimmunity is associated with HLA-antigen-T cell receptor complexes. The precise mechanisms underpinning this breach of tolerance are not well understood. Porphyromonas gingivalis expresses an enzyme capable of non-endogenous C-terminal citrullination with potential to generate citrullinated autoantigens. Here we document how C-terminal citrullination of ovalbumin peptide

Identifiants

DOI: 10.1016/j.jaut.2023.102994 PMID: 36706535
pubmed: 36706535
pii: S0896-8411(23)00003-3
doi: 10.1016/j.jaut.2023.102994
pii:
doi:

Substances chimiques

Citrulline 29VT07BGDA
Peptides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102994

Subventions

Organisme : Versus Arthritis
ID : 20823
Pays : United Kingdom

Informations de copyright

Crown Copyright © 2023. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest IBM has received grants and honoraria from BMS, Pfizer, Lilly, Abbvie, Gilead and Galapagos.

Auteurs

J Malcolm (J)

Oral Sciences, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK; Centre for Immunobiology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address: jennifer.malcolm@glasgow.ac.uk.

M H Nyirenda (MH)

Centre for Immunobiology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK; Research Into Inflammatory Arthritis Centre Versus Arthritis (RACE), Universities of Glasgow, Birmingham, Newcastle and Oxford, UK.

J L Brown (JL)

Oral Sciences, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK; Centre for Immunobiology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

A Adrados-Planell (A)

Centre for Immunobiology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK; Department of Genomics and Health, FISABIO Foundation, Avda Cataluña 21, 46020, Valencia, Spain.

L Campbell (L)

Centre for Immunobiology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

J P Butcher (JP)

Centre for Immunobiology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK; Department of Biological and Biomedical Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, United Kingdom.

D G Glass (DG)

Centre for Biophotonics, Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS), University of Strathclyde, Glasgow, United Kingdom.

K Piela (K)

Oral Sciences, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.

C S Goodyear (CS)

Centre for Immunobiology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK; Research Into Inflammatory Arthritis Centre Versus Arthritis (RACE), Universities of Glasgow, Birmingham, Newcastle and Oxford, UK.

A J Wright (AJ)

Centre for Biophotonics, Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS), University of Strathclyde, Glasgow, United Kingdom; Optics and Photonics Research Group, Faculty of Engineering, University of Nottingham, Nottingham, UK.

I B McInnes (IB)

Centre for Immunobiology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

O R Millington (OR)

Centre for Biophotonics, Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS), University of Strathclyde, Glasgow, United Kingdom.

S Culshaw (S)

Oral Sciences, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK; Centre for Immunobiology, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address: shauna.culshaw@glasgow.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › C-terminal citrullinated peptide alters...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés diaminés › Citrulline › C-terminal citrullinated peptide alters...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › C-terminal citrullinated peptide alters...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › C-terminal citrullinated peptide alters...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › C-terminal citrullinated peptide alters...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Communication cellulaire › C-terminal citrullinated peptide alters...