Cell starvation increases uptake of extracellular Thymosin β4 and its complexes with calcium.
Calcium
Cell starvation
Immunostaining
Thymosin β4
Tumour metastasis
Journal
International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
15
11
2022
revised:
09
01
2023
accepted:
09
01
2023
pubmed:
28
1
2023
medline:
9
3
2023
entrez:
27
1
2023
Statut:
ppublish
Résumé
Cell metastasis is the main cause of cancer mortality. Inhibiting early events during cell metastasis and invasion could significantly improve cancer prognosis, but the initial mechanisms of cell transition and migration are barely known. Calcium regulates cell migration, whilst Thymosin β4 is a G-actin and iron binding peptide associated with tumor metastasis and ferroptosis. Under normal cell growth conditions, intracellular free calcium ions and Thymosin β4 concentrations are strictly regulated, and are not influenced by extracellular supplementation. However, cell starvation decreases intracellular Thymosin β4 and increases extracellular peptide uptake above the normal range. Unexpectedly, cell starvation significantly increases internalization of extracellular Ca
Identifiants
pubmed: 36706591
pii: S1567-5769(23)00066-8
doi: 10.1016/j.intimp.2023.109743
pii:
doi:
Substances chimiques
Calcium
SY7Q814VUP
thymosin beta(4)
549LM7U24W
Thymosin
61512-21-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109743Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.