Training drives turnover rates in racehorse proximal sesamoid bones.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 01 2023
27 01 2023
Historique:
received:
25
04
2022
accepted:
08
12
2022
entrez:
27
1
2023
pubmed:
28
1
2023
medline:
1
2
2023
Statut:
epublish
Résumé
Focal bone lesions are often found prior to clinically relevant stress-fractures. Lesions are characterized by low bone volume fraction, low mineral density, and high levels of microdamage and are hypothesized to develop when bone tissue cannot sufficiently respond to damaging loading. It is difficult to determine how exercise drives the formation of these lesions because bone responds to mechanical loading and repairs damage. In this study, we derive steady-state rate constants for a compartment model of bone turnover using morphometric data from fractured and non-fractured racehorse proximal sesamoid bones (PSBs) and relate rate constants to racing-speed exercise data. Fractured PSBs had a subchondral focus of bone turnover and microdamage typical of lesions that develop prior to fracture. We determined steady-state model rate constants at the lesion site and an internal region without microdamage using bone volume fraction, tissue mineral density, and microdamage area fraction measurements. The derived undamaged bone resorption rate, damage formation rate, and osteoid formation rate had significant robust regression relationships to exercise intensity (rate) variables, layup (time out of exercise), and exercise 2-10 months before death. However, the direction of these relationships varied between the damaged (lesion) and non-damaged regions, reflecting that the biological response to damaging-loading differs from the response to non-damaging loading.
Identifiants
pubmed: 36707527
doi: 10.1038/s41598-022-26027-y
pii: 10.1038/s41598-022-26027-y
pmc: PMC9883508
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
205Informations de copyright
© 2023. The Author(s).
Références
Calcif Tissue Res. 1972;10(1):67-81
pubmed: 5054792
Microsc Res Tech. 1997 May 15;37(4):324-32
pubmed: 9185154
Calcif Tissue Int. 1993;53 Suppl 1:S57-64
pubmed: 8275381
J S Afr Vet Assoc. 2019 Feb 28;90(0):e1-e5
pubmed: 30843400
Equine Vet J. 2014 Jul;46(4):408-15
pubmed: 24528139
Equine Vet J. 1994 Jul;26(4):327-30
pubmed: 8575402
J Anat. 2003 Aug;203(2):161-72
pubmed: 12924817
Prev Vet Med. 1998 Jan;33(1-4):159-70
pubmed: 9500171
Bone. 2016 May;86:119-30
pubmed: 26946132
Equine Vet J. 2019 Jan;51(1):77-82
pubmed: 29672909
Vet J. 2014 Dec;202(3):443-7
pubmed: 25296852
J Orthop Res. 2022 Dec;40(12):2831-2842
pubmed: 35245393
Emerg Radiol. 2016 Aug;23(4):365-75
pubmed: 27002328
Bone. 2012 Jun;50(6):1281-7
pubmed: 22426306
Bone. 2001 Jul;29(1):74-8
pubmed: 11472894
Bone. 2014 Sep;66:205-13
pubmed: 24928495
J Biomed Mater Res A. 2010 Mar 1;92(3):1048-56
pubmed: 19301272
Osteoporos Int. 2003 Sep;14 Suppl 5:S22-7; discussion S27-8
pubmed: 14504702
Osteoporos Int. 2009 Jun;20(6):1023-6
pubmed: 19340504
J Orthop Res. 1998 May;16(3):322-9
pubmed: 9671927
Calcif Tissue Int. 2006 Sep;79(3):190-6
pubmed: 16969595
Clin Sports Med. 2006 Jan;25(1):37-52, viii
pubmed: 16324972
Equine Vet J. 2021 Nov;53(6):1169-1177
pubmed: 33244781
Clin Sports Med. 1997 Apr;16(2):291-306
pubmed: 9238311
J Biomech. 1985;18(3):189-200
pubmed: 3997903
Am J Vet Res. 2006 May;67(5):858-68
pubmed: 16649922
J Orthop Surg Res. 2018 Dec 5;13(1):309
pubmed: 30518382
Radiat Res. 1959 Feb;10(2):234-42
pubmed: 13645931
Sci Rep. 2019 Jun 11;9(1):8456
pubmed: 31186433
Bone. 2010 Apr;46(4):1204-12
pubmed: 19969115
Sports Med. 2022 Dec;52(12):2889-2908
pubmed: 35870108
Bone. 2010 Oct;47(4):826-31
pubmed: 20659599
Bone. 1997 May;20(5):477-84
pubmed: 9145246
Vet Surg. 2022 Aug;51(6):952-962
pubmed: 35672916
PLoS One. 2011;6(7):e21297
pubmed: 21750707
Nat Methods. 2019 Apr;16(4):275-276
pubmed: 30923374
Am J Vet Res. 2004 Nov;65(11):1508-17
pubmed: 15566089
Bone. 2010 Oct;47(4):766-72
pubmed: 20633708
J Am Vet Med Assoc. 1998 May 15;212(10):1582-7
pubmed: 9604029
Annu Rev Biomed Eng. 2006;8:455-98
pubmed: 16834564
Am J Physiol. 1974 Feb;226(2):345-52
pubmed: 4811191
Med Phys. 2002 Nov;29(11):2672-81
pubmed: 12462734
Ann N Y Acad Sci. 1963 May 10;108:36-68
pubmed: 13963664
J Bone Miner Res. 2006 Aug;21(8):1248-55
pubmed: 16869723
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Matrix Biol. 2008 Jan;27(1):34-41
pubmed: 17884405
Math Biosci. 2004 Oct;191(2):185-205
pubmed: 15363653
Osteoporos Int. 2013 Jul;24(7):2043-8
pubmed: 23371360
Calcif Tissue Int. 2002 Jun;70(6):503-11
pubmed: 12019458
Am J Vet Res. 2007 Jul;68(7):760-71
pubmed: 17605612
Bone. 1995 Oct;17(4):431-3
pubmed: 8573418
Equine Vet J. 2021 Mar;53(2):294-305
pubmed: 32474944