Invasion of intestinal cells by Staphylococcus warneri, a member of the human gut microbiota.
Coagulase-negative staphylococci
Gut microbiome
Gut microbiota
Host–bacteria interactions
Internalization
Intestinal epithelium
Intracellular bacteria
Pathogenic potential
Staphylococcus warneri
Journal
Gut pathogens
ISSN: 1757-4749
Titre abrégé: Gut Pathog
Pays: England
ID NLM: 101474263
Informations de publication
Date de publication:
27 Jan 2023
27 Jan 2023
Historique:
received:
18
10
2022
accepted:
20
12
2022
entrez:
28
1
2023
pubmed:
29
1
2023
medline:
29
1
2023
Statut:
epublish
Résumé
Coagulase negative staphylococci (CoNS) are a heterogeneous group of bacteria that colonize different types of human epithelia. These bacteria have a highly variable pathogenic potential ranging from avirulent species to major nosocomial pathogens. Staphylococcus warneri is a CoNS species considered to be nonpathogenic. Here, we identify that S. warneri is a natural member of both human and mouse gut microbiota. In addition, we demonstrate that this bacterium is able to get internalized into human cells. We show that S. warneri efficiently invades several human cell types and, more specifically, intestinal epithelial cells, using actin-dependent mechanisms. In contrast to bona fide pathogens, S. warneri does not actively replicate within intestinal cells or resist killing by macrophages. Together, our results highlight that bacteria from the human gut microbiota that are not associated with a high pathogenic potential, can actively invade intestinal cells and may, in this way, impact intestinal physiology.
Identifiants
pubmed: 36707889
doi: 10.1186/s13099-022-00528-7
pii: 10.1186/s13099-022-00528-7
pmc: PMC9881306
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4Informations de copyright
© 2023. The Author(s).
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