Interaction of Polystyrene Nanoparticles with Supported Lipid Bilayers: Impact of Nanoparticle Size and Protein Corona.

human serum albumin lipid bilayer nanoparticle size polystyrene nanoparticle protein corona transferrin

Journal

Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941

Informations de publication

Date de publication:
08 2023
Historique:
revised: 23 12 2022
received: 31 10 2022
medline: 21 8 2023
pubmed: 29 1 2023
entrez: 28 1 2023
Statut: ppublish

Résumé

Polystyrene is one of the most widely used plastics. This article reports on the interaction of 50 and 210 nm polystyrene nanoparticles (PSNPs) with human serum albumin (HSA) and transferrin (Tf), as well as their effect on supported lipid bilayers (SLBs), using experimental and theoretical approaches. Dynamic light scattering (DLS) and atomic force microscopy (AFM) measurements show that the increase in diameter for the PSNP-protein bioconjugates depends on nanoparticle size and type of proteins. The circular dichroism (CD) spectroscopy results demonstrate that the proteins preserve their structures when they interact with PSNPs at physiological temperatures. The quartz crystal microbalance (QCM) technique reveals that PSNPs and their bioconjugates show no strong interactions with SLBs. On the contrary, the molecular dynamics simulations (MDS) show that both proteins bind strongly to the lipid bilayer (SLBs) when compared to their binding to a polystyrene surface model. The interaction is strongly dependent on the protein and lipid bilayer composition. Both the PSNPs and their bioconjugates show no toxicity in human umbilical vein endothelial (HUVEC) cells; however, bare 210 nm PSNPs and 50 nm PSNP-Tf bioconjugates show an increase in reactive oxygen species production. This study may be relevant for assessing the impact of plastics on health.

Identifiants

pubmed: 36707930
doi: 10.1002/mabi.202200464
doi:

Substances chimiques

Lipid Bilayers 0
Polystyrenes 0
Protein Corona 0
Plastics 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2200464

Informations de copyright

© 2023 The Authors. Macromolecular Bioscience published by Wiley-VCH GmbH.

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Auteurs

Brahmaiah Meesaragandla (B)

Biophysical Chemistry, Institute of Biochemistry, Felix-Hausdorff-Straße 4, University of Greifswald, 17489, Greifswald, Germany.
ZIK-HIKE, Zentrum für Innovationskompetenz "Humorale Immunreaktionen bei kardiovaskulären Erkrankungen,", Fleischmannstraße 42, 17489, Greifswald, Germany.

Dennis Oliver Blessing (DO)

Biophysical Chemistry, Institute of Biochemistry, Felix-Hausdorff-Straße 4, University of Greifswald, 17489, Greifswald, Germany.
ZIK-HIKE, Zentrum für Innovationskompetenz "Humorale Immunreaktionen bei kardiovaskulären Erkrankungen,", Fleischmannstraße 42, 17489, Greifswald, Germany.

Sanjai Karanth (S)

Biophysical Chemistry, Institute of Biochemistry, Felix-Hausdorff-Straße 4, University of Greifswald, 17489, Greifswald, Germany.
ZIK-HIKE, Zentrum für Innovationskompetenz "Humorale Immunreaktionen bei kardiovaskulären Erkrankungen,", Fleischmannstraße 42, 17489, Greifswald, Germany.

Alena Rong (A)

Biophysical Chemistry, Institute of Biochemistry, Felix-Hausdorff-Straße 4, University of Greifswald, 17489, Greifswald, Germany.

Norman Geist (N)

Biophysical Chemistry, Institute of Biochemistry, Felix-Hausdorff-Straße 4, University of Greifswald, 17489, Greifswald, Germany.

Mihaela Delcea (M)

Biophysical Chemistry, Institute of Biochemistry, Felix-Hausdorff-Straße 4, University of Greifswald, 17489, Greifswald, Germany.
ZIK-HIKE, Zentrum für Innovationskompetenz "Humorale Immunreaktionen bei kardiovaskulären Erkrankungen,", Fleischmannstraße 42, 17489, Greifswald, Germany.
DZHK (Deutsches Zentrum für Herz-Kreislauf-Forschung), partner site Greifswald, 17489, Greifswald, Germany.

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