Subjective and objective evaluation of corneal haze after accelerated corneal crosslinking for corneal ectasias.
Humans
Photosensitizing Agents
/ therapeutic use
Photochemotherapy
Corneal Stroma
Retrospective Studies
Cohort Studies
Riboflavin
/ therapeutic use
Prospective Studies
Dilatation, Pathologic
/ drug therapy
Ultraviolet Rays
Corneal Topography
Keratoconus
/ diagnosis
Corneal Opacity
/ diagnosis
Cross-Linking Reagents
/ therapeutic use
Lupus Erythematosus, Systemic
/ drug therapy
accelerated crosslinking
corneal crosslinking
corneal densitometry
ectasia
haze
keratoconus
Journal
Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
revised:
12
12
2022
received:
20
04
2022
accepted:
08
01
2023
medline:
11
7
2023
pubmed:
29
1
2023
entrez:
28
1
2023
Statut:
ppublish
Résumé
To evaluate the relationship between subjective (slit lamp examination [SLE]) and objective (densitometry) measurements of corneal haze after accelerated corneal crosslinking (aCXL), assess the relationship between densitometry and corrected distance visual acuity (CDVA), and determine the effect of baseline characteristics on densitometry after aCXL in eyes with progressive keratoconus and other ectasias. Kensington Eye Institute and Bochner Eye Institute, Toronto, Canada. Retrospective analysis of a prospective interventional cohort study. Scheimpflug-derived corneal densitometry, CDVA, maximum keratometry (K There was a significant association between subjective haze with SLE and densitometry (p < 0.001). There was a significant relationship between CDVA and densitometry: for every 10 GSUs of increased densitometry in the 0-2 mm zone, CDVA worsened by approximately half a Snellen line (p < 0.001). Age and pre-operative K Subjective haze after aCXL estimated with SLE, is significantly associated with densitometry. Increased densitometry after aCXL is associated with a reduction in CDVA.
Substances chimiques
Photosensitizing Agents
0
Riboflavin
TLM2976OFR
Cross-Linking Reagents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
568-574Informations de copyright
© 2023 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
Références
Akkaya Turhan, S. & Toker, E. (2017) Changes in corneal density after accelerated corneal collagen cross-linking with different irradiation intensities and energy exposures: 1-year follow-up. Cornea, 36, 1331-1335.
Alnawaiseh, M., Rosentreter, A., Eveslage, M., Eter, N. & Zumhagen, L. (2015) Changes in corneal transparency after cross-linking for progressive keratoconus: long-term follow-up. Journal of Refractive Surgery, 31, 614-618.
Badawi, A.E. (2021) Corneal haze and densitometry in keratoconus after collagen cross-linking by three different protocols. Journal of Current Ophthalmology, 33, 422-430.
Cennamo, G., Forte, R., Aufiero, B. & La Rana, A. (2011) Computerized Scheimpflug densitometry as a measure of corneal optical density after excimer laser refractive surgery in myopic eyes. Journal of Cataract and Refractive Surgery, 37, 1502-1506.
Chan, T.C.Y., Chan, J.C.K., Wang, Y.M. & Rapuano, C.J. (2018) Survival analysis of corneal densitometry after collagen cross-linking for progressive keratoconus. Cornea, 37, 1449-1456.
Eissa, S.A., Badr Eldin, N., Nossair, A.A. & Ewais, W.A. (2017) Primary outcomes of accelerated epithelium-off corneal cross-linking in progressive keratoconus in children: a 1-year prospective study. Journal of Ophthalmology, 2017, 1923161-1923169.
Eissa, S.A. & Yassin, A. (2019) Prospective, randomized contralateral eye study of accelerated and conventional corneal cross-linking in pediatric keratoconus. International Ophthalmology, 39, 971-979.
Fitzmaurice, G.M., Laird, N.M. & Ware, J.H. (2011) Applied longitudinal analysis, 2nd edition. Hoboken, NJ: John Wiley & Sons.
Greenstein, S.A., Fry, K.L., Bhatt, J. & Hersh, P.S. (2010) Natural history of corneal haze after collagen crosslinking for keratoconus and corneal ectasia: Scheimpflug and biomicroscopic analysis. Journal of Cataract and Refractive Surgery, 36, 2105-2114.
Gutierrez, R., Lopez, I., Villa-Collar, C. & Gonzalez-Meijome, J.M. (2012) Corneal transparency after cross-linking for keratoconus: 1-year follow-up. Journal of Refractive Surgery, 28, 781-786.
Hanna, K.D., Pouliquen, Y.M., Waring, G.O., 3rd, Savoldelli, M., Fantes, F. & Thompson, K.P. (1992) Corneal wound healing in monkeys after repeated excimer laser photorefractive keratectomy. Archives of Ophthalmology, 110, 1286-1291.
Hashemi, H., Taheri, S.M., Fotouhi, A. & Kheiltash, A. (2004) Evaluation of the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy in high myopia: a prospective clinical study. BMC Ophthalmology, 4, 12.
Hatch, W., El-Defrawy, S., Ong Tone, S., Stein, R., Slomovic, A.R., Rootman, D.S. et al. (2020) Accelerated corneal cross-linking: efficacy, risk of progression, and characteristics affecting outcomes. A large, single-center prospective study. American Journal of Ophthalmology, 213, 76-87.
Hersh, P.S., Stulting, R.D., Muller, D., Durrie, D.S., Rajpal, R.K. & U. S. Crosslinking Study Group. (2017) U.S. multicenter clinical trial of corneal collagen crosslinking for treatment of corneal ectasia after refractive surgery. Ophthalmology, 124, 1475-1484.
Kim, B.Z., Jordan, C.A., McGhee, C.N. & Patel, D.V. (2016) Natural history of corneal haze after corneal collagen crosslinking in keratoconus using Scheimpflug analysis. Journal of Cataract and Refractive Surgery, 42, 1053-1059.
Koc, M., Uzel, M.M., Tekin, K., Kosekahya, P., Ozulken, K. & Yilmazbas, P. (2016) Effect of preoperative factors on visual acuity, corneal flattening, and corneal haze after accelerated corneal crosslinking. Journal of Cataract and Refractive Surgery, 42, 1483-1489.
Ni Dhubhghaill, S., Rozema, J.J., Jongenelen, S., Ruiz Hidalgo, I., Zakaria, N. & Tassignon, M.J. (2014) Normative values for corneal densitometry analysis by Scheimpflug optical assessment. Investigative Ophthalmology & Visual Science, 55, 162-168.
Otri, A.M., Fares, U., Al-Aqaba, M.A. & Dua, H.S. (2012) Corneal densitometry as an indicator of corneal health. Ophthalmology, 119, 501-508.
Pircher, N., Pachala, M., Prager, F., Pieh, S. & Schmidinger, G. (2015) Changes in straylight and densitometry values after corneal collagen crosslinking. Journal of Cataract and Refractive Surgery, 41, 1038-1043.
Shen, Y., Jian, W., Sun, L., Li, M., Han, T., Son, J. et al. (2016) One-year follow-up of changes in corneal densitometry after accelerated (45 mW/cm2) transepithelial corneal collagen cross-linking for keratoconus: a retrospective study. Cornea, 35, 1434-1440.
Vinciguerra, P., Albe, E., Trazza, S., Rosetta, P., Vinciguerra, R., Seiler, T. et al. (2009) Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology, 116, 369-378.
Wollensak, G., Spoerl, E. & Seiler, T. (2003) Riboflavin/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. American Journal of Ophthalmology, 135, 620-627.