Longitudinal changes in global structural brain connectivity and cognitive performance in former hospitalized COVID-19 survivors: an exploratory study.
Magnetic resonance imaging
Recovery
SARS-CoV-2
Journal
Experimental brain research
ISSN: 1432-1106
Titre abrégé: Exp Brain Res
Pays: Germany
ID NLM: 0043312
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
06
09
2022
accepted:
02
01
2023
pubmed:
29
1
2023
medline:
8
3
2023
entrez:
28
1
2023
Statut:
ppublish
Résumé
Long-term sequelae of COVID-19 can result in reduced functionality of the central nervous system and substandard quality of life. Gaining insight into the recovery trajectory of admitted COVID-19 patients on their cognitive performance and global structural brain connectivity may allow a better understanding of the diseases' relevance. To assess whole-brain structural connectivity in former non-intensive-care unit (ICU)- and ICU-admitted COVID-19 survivors over 2 months following hospital discharge and correlate structural connectivity measures to cognitive performance. Participants underwent Magnetic Resonance Imaging brain scans and a cognitive test battery after hospital discharge to evaluate structural connectivity and cognitive performance. Multilevel models were constructed for each graph measure and cognitive test, assessing the groups' influence, time since discharge, and interactions. Linear regression models estimated whether the graph measurements affected cognitive measures and whether they differed between ICU and non-ICU patients. Six former ICU and six non-ICU patients completed the study. Across the various graph measures, the characteristic path length decreased over time (β = 0.97, p = 0.006). We detected no group-level effects (β = 1.07, p = 0.442) nor interaction effects (β = 1.02, p = 0.220). Cognitive performance improved for both non-ICU and ICU COVID-19 survivors on four out of seven cognitive tests 2 months later (p < 0.05). Adverse effects of COVID-19 on brain functioning and structure abate over time. These results should be supported by future research including larger sample sizes, matched control groups of healthy non-infected individuals, and more extended follow-up periods.
Sections du résumé
BACKGROUND
BACKGROUND
Long-term sequelae of COVID-19 can result in reduced functionality of the central nervous system and substandard quality of life. Gaining insight into the recovery trajectory of admitted COVID-19 patients on their cognitive performance and global structural brain connectivity may allow a better understanding of the diseases' relevance.
OBJECTIVES
OBJECTIVE
To assess whole-brain structural connectivity in former non-intensive-care unit (ICU)- and ICU-admitted COVID-19 survivors over 2 months following hospital discharge and correlate structural connectivity measures to cognitive performance.
METHODS
METHODS
Participants underwent Magnetic Resonance Imaging brain scans and a cognitive test battery after hospital discharge to evaluate structural connectivity and cognitive performance. Multilevel models were constructed for each graph measure and cognitive test, assessing the groups' influence, time since discharge, and interactions. Linear regression models estimated whether the graph measurements affected cognitive measures and whether they differed between ICU and non-ICU patients.
RESULTS
RESULTS
Six former ICU and six non-ICU patients completed the study. Across the various graph measures, the characteristic path length decreased over time (β = 0.97, p = 0.006). We detected no group-level effects (β = 1.07, p = 0.442) nor interaction effects (β = 1.02, p = 0.220). Cognitive performance improved for both non-ICU and ICU COVID-19 survivors on four out of seven cognitive tests 2 months later (p < 0.05).
CONCLUSION
CONCLUSIONS
Adverse effects of COVID-19 on brain functioning and structure abate over time. These results should be supported by future research including larger sample sizes, matched control groups of healthy non-infected individuals, and more extended follow-up periods.
Identifiants
pubmed: 36708380
doi: 10.1007/s00221-023-06545-5
pii: 10.1007/s00221-023-06545-5
pmc: PMC9883830
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
727-741Subventions
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 11B9919N
Informations de copyright
© 2023. The Author(s).
Références
Eur Radiol. 2020 Jul;30(7):3843-3851
pubmed: 32162002
Cogn Neurodyn. 2018 Apr;12(2):157-170
pubmed: 29564025
Neuroimage Clin. 2015 May 16;8:367-75
pubmed: 26106562
Sleep. 2011 May 01;34(5):581-91
pubmed: 21532951
Brain Behav Immun. 2020 Aug;88:957-958
pubmed: 32590055
Neuroimage. 1995 Jun;2(2):89-101
pubmed: 9343592
CMAJ Open. 2021 Nov 30;9(4):E1114-E1119
pubmed: 34848552
Radiology. 2020 Nov;297(2):E242-E251
pubmed: 32544034
Nat Microbiol. 2020 Apr;5(4):536-544
pubmed: 32123347
Aerosp Med Hum Perform. 2015 Nov;86(11):942-52
pubmed: 26564759
Alzheimers Dement. 2021 Jun;17(6):1056-1065
pubmed: 33399270
Neuroradiol J. 2022 Feb;35(1):3-24
pubmed: 34224248
CMAJ. 2021 Aug 30;193(34):E1360-E1361
pubmed: 34462298
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
J Alzheimers Dis. 2020;76(1):3-19
pubmed: 32538857
J Neurol. 2021 Aug;268(8):2676-2684
pubmed: 33219827
Med Image Anal. 2013 Aug;17(6):671-84
pubmed: 23510558
Neuroimage. 2008 Aug 15;42(2):902-10
pubmed: 18582578
Neurology. 2021 Jan 26;96(4):e575-e586
pubmed: 33020166
EClinicalMedicine. 2020 Aug;25:100484
pubmed: 32838240
Cell. 2020 Oct 1;183(1):16-27.e1
pubmed: 32882182
Brain. 2022 Jun 3;145(5):1830-1838
pubmed: 34918020
Magn Reson Imaging. 2019 Dec;64:62-70
pubmed: 31075422
EClinicalMedicine. 2021 Sep;39:101044
pubmed: 34316551
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33433624
JAMA. 2016 Feb 23;315(8):749-50
pubmed: 26903329
J Nucl Med. 2021 Jul 1;62(7):910-915
pubmed: 33789937
Transl Psychiatry. 2021 May 21;11(1):307
pubmed: 34021116
Neuropsychologia. 1995 Aug;33(8):1027-46
pubmed: 8524452
Clin Microbiol Infect. 2021 Mar;27(3):458-466
pubmed: 33189873
Neurology. 2020 Sep 29;95(13):e1868-e1882
pubmed: 32680942
Eur J Neurol. 2021 Oct;28(10):3245-3253
pubmed: 33576150
Nature. 2022 Apr;604(7907):697-707
pubmed: 35255491
Ann N Y Acad Sci. 2015 Sep;1353:60-71
pubmed: 26132277
EBioMedicine. 2021 Aug;70:103512
pubmed: 34333238
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
J Exp Psychol Appl. 2002 Jun;8(2):75-84
pubmed: 12075692
J Neurol Sci. 2021 Jul 15;426:117486
pubmed: 34000678
Neuroimage. 2019 Jan 1;184:801-812
pubmed: 30267859
Brain. 2021 May 7;144(4):1263-1276
pubmed: 33822001
BMC Infect Dis. 2022 Jan 27;22(1):93
pubmed: 35086489
Neuroimage. 2019 Nov 15;202:116137
pubmed: 31473352
Brain Behav. 2016 Jul 19;6(9):e00518
pubmed: 27688944
Neuroimage. 2012 Sep;62(3):1924-38
pubmed: 22705374
Eur J Neurol. 2022 Apr;29(4):1218-1221
pubmed: 34918425
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Neuroimage. 2013 Feb 15;67:298-312
pubmed: 23238430
Eur Arch Psychiatry Clin Neurosci. 2022 Aug;272(5):773-782
pubmed: 34698871
Neuroimage. 2015 Oct 1;119:338-51
pubmed: 26163802
Neurol Sci. 2020 Oct;41(10):2657-2669
pubmed: 32725449
Brain Behav Immun. 2020 Aug;88:11-16
pubmed: 32416289
Cogn Neurodyn. 2020 Apr;14(2):215-228
pubmed: 32226563
Eur J Neurol. 2020 Nov;27(11):2322-2328
pubmed: 32681611
Clin Neurol Neurosurg. 2020 Jul;194:105921
pubmed: 32422545
Neural Comput. 2017 Feb;29(2):313-331
pubmed: 27870616
Neuroimage. 2011 Feb 1;54(3):2033-44
pubmed: 20851191
Neuroimage. 2007 May 1;35(4):1459-72
pubmed: 17379540
Epilepsy Behav. 2014 Sep;38:71-80
pubmed: 24374054
Chest. 2006 Sep;130(3):869-78
pubmed: 16963688
Neuroimage. 2012 Aug 15;62(2):774-81
pubmed: 22248573