Polymer-based particles against pathogenic fungi: A non-uptake delivery of compounds.
Antifungal
Aspergillus fumigatus
Invasive fungal infections
Polymeric particles
Journal
Biomaterials advances
ISSN: 2772-9508
Titre abrégé: Biomater Adv
Pays: Netherlands
ID NLM: 9918383886206676
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
22
08
2022
revised:
14
12
2022
accepted:
13
01
2023
pubmed:
29
1
2023
medline:
25
2
2023
entrez:
28
1
2023
Statut:
ppublish
Résumé
The therapy of life-threatening fungal infections is limited and needs urgent improvement. This is in part due to toxic side effects of clinically used antifungal compounds or their limited delivery to fungal structures. Until today, it is a matter of debate how drugs or drug-delivery systems can efficiently reach the intracellular lumen of fungal cells and how this can be improved. Here, we addressed both questions by applying two different polymeric particles for delivery of compounds. Their formulation was based on two biocompatible polymers, i.e., poly(lactic-co-glycolic acid)
Identifiants
pubmed: 36708684
pii: S2772-9508(23)00023-7
doi: 10.1016/j.bioadv.2023.213300
pii:
doi:
Substances chimiques
Antifungal Agents
0
Itraconazole
304NUG5GF4
Polymers
0
Fluorescent Dyes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
213300Subventions
Organisme : Austrian Science Fund FWF
ID : J 4432
Pays : Austria
Informations de copyright
Copyright © 2023. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.