Pharmacological inhibition of lysosomal two-pore channel 2 (TPC2) confers neuroprotection in stroke via autophagy regulation.

Animals Rats Autophagy Brain Ischemia / metabolism Endoplasmic Reticulum Chaperone BiP Hypoxia / metabolism Infarction, Middle Cerebral Artery / metabolism Lysosomes / metabolism Neuroprotection Neurotoxins Stroke / drug therapy
Autophagy ER stress Focal ischemia Hypoxia Lysosomal function TPC2

Journal

Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169

Informations de publication

Date de publication:
03 2023
Historique:
received: 06 10 2022
revised: 29 12 2022
accepted: 24 01 2023
pubmed: 29 1 2023
medline: 16 2 2023
entrez: 28 1 2023
Statut: ppublish

Résumé

Lysosomal function and organellar Ca

Identifiants

DOI: 10.1016/j.nbd.2023.106020 PMID: 36708960
pubmed: 36708960
pii: S0969-9961(23)00034-7
doi: 10.1016/j.nbd.2023.106020
pii:
doi:

Substances chimiques

Endoplasmic Reticulum Chaperone BiP 0
Neurotoxins 0
Tpcn2 protein, rat 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106020

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Valentina Tedeschi (V)

Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatological Sciences, School of Medicine, "Federico II" University of Naples, Via Sergio Pansini 5, Naples 80131, Italy. Electronic address: valentina.tedeschi@unina.it.

Antonio Vinciguerra (A)

Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", Via Tronto 10/A, Ancona 60126, Italy. Electronic address: a.vinciguerra@univpm.it.

Maria Josè Sisalli (MJ)

Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatological Sciences, School of Medicine, "Federico II" University of Naples, Via Sergio Pansini 5, Naples 80131, Italy. Electronic address: mariajose.sisalli@unina.it.

Giuseppe Pignataro (G)

Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatological Sciences, School of Medicine, "Federico II" University of Naples, Via Sergio Pansini 5, Naples 80131, Italy. Electronic address: gpignata@unina.it.

Agnese Secondo (A)

Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatological Sciences, School of Medicine, "Federico II" University of Naples, Via Sergio Pansini 5, Naples 80131, Italy. Electronic address: secondo@unina.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Pharmacological inhibition of lysosomal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Pharmacological inhibition of lysosomal...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Pharmacological inhibition of lysosomal...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Encéphalopathie ischémique › Pharmacological inhibition of lysosomal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Chaperons moléculaires › Protéines du choc thermique › Protéines du choc thermique HSP70 › Chaperonne BiP du réticulum endoplasmique › Pharmacological inhibition of lysosomal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Pharmacological inhibition of lysosomal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus encéphalique › Infarctus cérébral › Infarctus du territoire de l'artère cérébrale moyenne › Pharmacological inhibition of lysosomal...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Pharmacological inhibition of lysosomal...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neuroprotection › Pharmacological inhibition of lysosomal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Neurotoxines › Pharmacological inhibition of lysosomal...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Pharmacological inhibition of lysosomal...