Prevalence of neonicotinoid insecticides in paired private-well tap water and human urine samples in a region of intense agriculture overlying vulnerable aquifers in eastern Iowa.


Journal

Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657

Informations de publication

Date de publication:
Apr 2023
Historique:
received: 18 10 2022
revised: 19 12 2022
accepted: 16 01 2023
pmc-release: 01 04 2024
pubmed: 30 1 2023
medline: 22 2 2023
entrez: 29 1 2023
Statut: ppublish

Résumé

A pilot study among farming households in eastern Iowa was conducted to assess human exposure to neonicotinoids (NEOs). The study was in a region with intense crop and livestock production and where groundwater is vulnerable to surface-applied contaminants. In addition to paired outdoor (hydrant) water and indoor (tap) water samples from private wells, urine samples were collected from 47 adult male pesticide applicators along with the completions of dietary and occupational surveys. Estimated Daily Intake (EDI) were then calculated to examine exposures for different aged family members. NEOs were detected in 53% of outdoor and 55% of indoor samples, with two or more NEOs in 13% of samples. Clothianidin was the most frequently detected NEO in water samples. Human exposure was ubiquitous in urine samples. A median of 10 different NEOs and/or metabolites were detected in urine, with clothianidin, nitenpyram, thiamethoxam, 6-chloronicotinic acid, and thiacloprid amide detected in every urine samples analyzed. Dinotefuran, imidaclothiz, acetamiprid-N-desmethyl, and N-desmethyl thiamethoxam were found in ≥70% of urine samples. Observed water intake for study participants and EDIs were below the chronic reference doses (CRfD) and acceptable daily intake (ADI) standards for all NEOs indicating minimal risk from ingestion of tap water. The study results indicate that while the consumption of private well tap water provides a human exposure pathway, the companion urine results provide evidence that diet and/or other exposure pathways (e.g., occupational, house dust) may contribute to exposure more than water contamination. Further biomonitoring research is needed to better understand the scale of human exposure from different sources.

Identifiants

pubmed: 36709846
pii: S0045-6535(23)00171-6
doi: 10.1016/j.chemosphere.2023.137904
pmc: PMC9957962
mid: NIHMS1871889
pii:
doi:

Substances chimiques

clothianidin 2V9906ABKQ
Insecticides 0
Thiamethoxam 747IC8B487
Neonicotinoids 0
Nitro Compounds 0
Water 059QF0KO0R

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

137904

Subventions

Organisme : NIEHS NIH HHS
ID : P30 ES005605
Pays : United States
Organisme : NIOSH CDC HHS
ID : T42 OH008491
Pays : United States
Organisme : ACL HHS
ID : T42OH008491
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Références

Chemosphere. 2021 Oct;281:130856
pubmed: 34029958
Environ Health. 2019 Jan 11;18(1):7
pubmed: 30634980
Environ Health Perspect. 2017 Feb;125(2):155-162
pubmed: 27385285
Chemosphere. 2017 Dec;188:130-138
pubmed: 28881240
Environ Res. 2019 Sep;176:108555
pubmed: 31288196
Sci Total Environ. 2021 Feb 25;757:143822
pubmed: 33246718
Annu Rev Pharmacol Toxicol. 2005;45:247-68
pubmed: 15822177
Comp Biochem Physiol C Toxicol Pharmacol. 2017 Jan;191:1-6
pubmed: 27612665
Anal Bioanal Chem. 2019 Jan;411(3):669-678
pubmed: 30483854
J Toxicol Environ Health A. 2015;78(21-22):1338-47
pubmed: 26555155
J Epidemiol Community Health. 2006 Feb;60(2):168-72
pubmed: 16415269
Environ Res. 2021 Aug;199:111175
pubmed: 33964309
J Agric Food Chem. 2021 Apr 14;69(14):4064-4073
pubmed: 33787257
Environ Sci Process Impacts. 2020 Jun 24;22(6):1315-1346
pubmed: 32267911
Environ Health Perspect. 2009 Dec;117(12):1912-8
pubmed: 20049211
Environ Sci Pollut Res Int. 2015 Jan;22(1):103-18
pubmed: 24938819
Pest Manag Sci. 2015 Jun;71(6):850-62
pubmed: 25351824
Environ Sci Technol. 2012 Mar 6;46(5):2592-9
pubmed: 22292570
Environ Sci Technol. 2018 Mar 20;52(6):3329-3335
pubmed: 29481746
Environ Pollut. 2018 Apr;235:1022-1029
pubmed: 29357997
Environ Toxicol Chem. 2016 Feb;35(2):303-10
pubmed: 26395849
Insect Biochem Mol Biol. 2011 Jul;41(7):432-9
pubmed: 21296156
Sci Total Environ. 2000 Apr 5;248(2-3):115-22
pubmed: 10805232
J Toxicol. 2012;2012:612647
pubmed: 22545045
Environ Sci Technol. 2015 Apr 21;49(8):5088-97
pubmed: 25793443
Toxicol Appl Pharmacol. 2004 Aug 1;198(3):243-52
pubmed: 15276403
Sci Total Environ. 2015 Dec 1;536:481-488
pubmed: 26232757
Int J Cancer. 2015 Jul 1;137(1):173-82
pubmed: 25430487
Environ Int. 2020 Feb;135:105415
pubmed: 31869729
J Agric Food Chem. 2014 Jul 2;62(26):6082-90
pubmed: 24933495
Science. 2013 May 10;340(6133):674-6
pubmed: 23661734
Chudoku Kenkyu. 2011 Sep;24(3):222-30
pubmed: 21950025
Environ Int. 2020 Dec;145:106120
pubmed: 32949879
BMC Public Health. 2014 Sep 15;14:955
pubmed: 25224535
Pest Manag Sci. 2007 Oct;63(10):969-73
pubmed: 17659536
Pest Manag Sci. 2016 Feb;72(2):388-97
pubmed: 25884469
Environ Health Perspect. 2017 Feb 1;125(2):A41-A42
pubmed: 28145869
Sci Total Environ. 2019 Jul 20;675:513-519
pubmed: 31030157
Environ Pollut. 2014 Oct;193:189-196
pubmed: 25042208
Environ Int. 2020 Oct;143:105918
pubmed: 32673906
J Agric Food Chem. 2011 Apr 13;59(7):2897-908
pubmed: 20565065
PLoS One. 2012;7(2):e32432
pubmed: 22393406
PLoS One. 2015 Nov 04;10(11):e0142172
pubmed: 26535579
Environ Sci Pollut Res Int. 2015 Jan;22(1):5-34
pubmed: 25233913
Chem Res Toxicol. 2006 Nov;19(11):1549-56
pubmed: 17112244
Chem Res Toxicol. 2006 Jul;19(7):944-51
pubmed: 16841963
Sci Total Environ. 2019 Dec 10;695:133790
pubmed: 31422335
PLoS One. 2017 Mar 10;12(3):e0173836
pubmed: 28282441

Auteurs

Darrin A Thompson (DA)

University of Iowa, College of Public Health, Iowa, IA, USA; University of Iowa, Center for Health Effects of Environmental Contamination, Iowa, IA, USA. Electronic address: Darrin-thompson-1@uiowa.edu.

Dana W Kolpin (DW)

U.S. Geological Survey, Central Midwest Water Science Center, Iowa, IA, USA.

Michelle L Hladik (ML)

U.S. Geological Survey, California Water Science Center, Sacramento, CA, USA.

Hans-Joachim Lehmler (HJ)

University of Iowa, College of Public Health, Iowa, IA, USA.

Shannon M Meppelink (SM)

U.S. Geological Survey, Central Midwest Water Science Center, Iowa, IA, USA.

Matthew C Poch (MC)

University of Iowa, College of Public Health, Iowa, IA, USA.

John D Vargo (JD)

State Hygienic Laboratory at the University of Iowa, Iowa, IA, USA.

Victor A Soupene (VA)

University of Iowa, College of Public Health, Iowa, IA, USA.

Nafis Md Irfan (NM)

Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa, IA, USA; University of Iowa, Department of Internal Medicine, Iowa, IA, USA; University of Dhaka, Institute of Nutrition and Food Science, Dhaka, Bangladesh.

Morgan Robinson (M)

Department of Pediatrics, New York University School of Medicine, New York, NY, USA.

Kurunthachalam Kannan (K)

Department of Pediatrics, New York University School of Medicine, New York, NY, USA; Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.

Laura E Beane Freeman (LE)

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Jonathan N Hofmann (JN)

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

David M Cwiertny (DM)

University of Iowa, College of Public Health, Iowa, IA, USA; Department of Civil and Environmental Engineering, University of Iowa, Iowa, IA, USA; Public Policy Center, University of Iowa, Iowa City, IA, USA.

R William Field (RW)

University of Iowa, College of Public Health, Iowa, IA, USA.

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Classifications MeSH